Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders
Immunosuppressive drugs given during pregnancy to mothers suffering from a systemic autoimmune disease (AID) can cross the placenta, thus being potentially able to affect the offspring immune system. Aim of our study was to evaluate the in vivo immune function of a series of these newborns. Twenty-t...
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| Veröffentlicht in: | Lupus 2007-01, Vol.16 (2), p.129-132 |
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| creator | Cimaz, R Meregalli, E Biggioggero, M Airò, P Danieli, E Antonioli, C M Motta, M Chirico, G Columbrita, D Frassi, M Meroni, P L Tincani, A |
| description | Immunosuppressive drugs given during pregnancy to mothers suffering from a systemic autoimmune disease (AID) can cross the placenta, thus being potentially able to affect the offspring immune system. Aim of our study was to evaluate the in vivo immune function of a series of these newborns. Twenty-two babies born from mothers suffering from autoimmune diseases (AID) who had been taking immunosuppressive drugs during pregnancy were evaluated for their response to vaccination with C. Tetani toxoid. Six babies born from mothers receiving low-dose aspirin only were used as controls. The immune response to C. Tetani vaccination was evaluated with an ELISA to detect circulating antibodies. Five children out of 28 (17%) did not achieve a protective titer of anti C. Tetanitoxoid IgG. No clear relationship was found between specific drug exposure and antibody response. Our findings suggest that maternal immunosuppressive treatment given for a systemic AID can affect the response to an active immunization, without specificities for drug types used. |
| doi_str_mv | 10.1177/0961203306075738 |
| format | Article |
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Aim of our study was to evaluate the in vivo immune function of a series of these newborns. Twenty-two babies born from mothers suffering from autoimmune diseases (AID) who had been taking immunosuppressive drugs during pregnancy were evaluated for their response to vaccination with C. Tetani toxoid. Six babies born from mothers receiving low-dose aspirin only were used as controls. The immune response to C. Tetani vaccination was evaluated with an ELISA to detect circulating antibodies. Five children out of 28 (17%) did not achieve a protective titer of anti C. Tetanitoxoid IgG. No clear relationship was found between specific drug exposure and antibody response. Our findings suggest that maternal immunosuppressive treatment given for a systemic AID can affect the response to an active immunization, without specificities for drug types used.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203306075738</identifier><identifier>PMID: 17402369</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adult ; Age ; Antibodies ; Antibodies - blood ; Aspirin ; Autoimmune diseases ; Autoimmune Diseases - drug therapy ; Babies ; Clostridium tetani ; Connective tissue diseases ; Drug dosages ; Female ; Fetus - drug effects ; Humans ; Immune system ; Immunosuppressive agents ; Immunosuppressive Agents - pharmacology ; Immunosuppressive Agents - therapeutic use ; Infant, Newborn ; Lupus ; Male ; Mothers ; Newborn babies ; Pregnancy ; Pregnancy Complications - drug therapy ; Tetanus ; Tetanus Toxoid - immunology</subject><ispartof>Lupus, 2007-01, Vol.16 (2), p.129-132</ispartof><rights>SAGE Publications © Feb 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-c2086b62a6a0b7b5cda30892459f39f56edb0fe48553dc0a50b8bdfdbd59e3073</citedby><cites>FETCH-LOGICAL-c393t-c2086b62a6a0b7b5cda30892459f39f56edb0fe48553dc0a50b8bdfdbd59e3073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203306075738$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203306075738$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17402369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cimaz, R</creatorcontrib><creatorcontrib>Meregalli, E</creatorcontrib><creatorcontrib>Biggioggero, M</creatorcontrib><creatorcontrib>Airò, P</creatorcontrib><creatorcontrib>Danieli, E</creatorcontrib><creatorcontrib>Antonioli, C M</creatorcontrib><creatorcontrib>Motta, M</creatorcontrib><creatorcontrib>Chirico, G</creatorcontrib><creatorcontrib>Columbrita, D</creatorcontrib><creatorcontrib>Frassi, M</creatorcontrib><creatorcontrib>Meroni, P L</creatorcontrib><creatorcontrib>Tincani, A</creatorcontrib><title>Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Immunosuppressive drugs given during pregnancy to mothers suffering from a systemic autoimmune disease (AID) can cross the placenta, thus being potentially able to affect the offspring immune system. Aim of our study was to evaluate the in vivo immune function of a series of these newborns. Twenty-two babies born from mothers suffering from autoimmune diseases (AID) who had been taking immunosuppressive drugs during pregnancy were evaluated for their response to vaccination with C. Tetani toxoid. Six babies born from mothers receiving low-dose aspirin only were used as controls. The immune response to C. Tetani vaccination was evaluated with an ELISA to detect circulating antibodies. Five children out of 28 (17%) did not achieve a protective titer of anti C. Tetanitoxoid IgG. No clear relationship was found between specific drug exposure and antibody response. Our findings suggest that maternal immunosuppressive treatment given for a systemic AID can affect the response to an active immunization, without specificities for drug types used.</description><subject>Adult</subject><subject>Age</subject><subject>Antibodies</subject><subject>Antibodies - blood</subject><subject>Aspirin</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Babies</subject><subject>Clostridium tetani</subject><subject>Connective tissue diseases</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Fetus - drug effects</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunosuppressive agents</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Infant, Newborn</subject><subject>Lupus</subject><subject>Male</subject><subject>Mothers</subject><subject>Newborn babies</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - drug therapy</subject><subject>Tetanus</subject><subject>Tetanus Toxoid - immunology</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0cFq3DAQBmBRUrqbtPeegsmhN6cjaSVZxxLSNhAohORsZGtcvKwtRyOV9O1jZxcWAiEgEMx8M0L8jH3lcMm5Md_Bai5AStBglJHVB7bmG2PKuS5O2Hppl0t_xU6JtgAgudWf2IqbDQip7ZrRHdIURsIihSJhcmOm4p9r2350qQ9j0S-nc2OiAp-mQOiXUk4YwzLSD0MeA-Vpikj0wroQi8HNYHS7wuUUXgwWvqcQPUb6zD52bkf45XCfsYef1_dXv8vbP79urn7clq20MpWtgEo3WjjtoDGNar2TUFmxUbaTtlMafQMdbiqlpG_BKWiqxne-8cqiBCPP2Lf93imGx4yU6qGnFnc7N2LIVBuQwhoL70IBmoNQ1QwvXsFtyMs_ZyOElpZLMSPYozYGoohdPcV-cPF_zaFeYqtfxzaPnB_25mZAfxw45DSDcg_I_cXjo28ufAav06Gj</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Cimaz, R</creator><creator>Meregalli, E</creator><creator>Biggioggero, M</creator><creator>Airò, P</creator><creator>Danieli, E</creator><creator>Antonioli, C M</creator><creator>Motta, M</creator><creator>Chirico, G</creator><creator>Columbrita, D</creator><creator>Frassi, M</creator><creator>Meroni, P L</creator><creator>Tincani, A</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders</title><author>Cimaz, R ; 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Aim of our study was to evaluate the in vivo immune function of a series of these newborns. Twenty-two babies born from mothers suffering from autoimmune diseases (AID) who had been taking immunosuppressive drugs during pregnancy were evaluated for their response to vaccination with C. Tetani toxoid. Six babies born from mothers receiving low-dose aspirin only were used as controls. The immune response to C. Tetani vaccination was evaluated with an ELISA to detect circulating antibodies. Five children out of 28 (17%) did not achieve a protective titer of anti C. Tetanitoxoid IgG. No clear relationship was found between specific drug exposure and antibody response. Our findings suggest that maternal immunosuppressive treatment given for a systemic AID can affect the response to an active immunization, without specificities for drug types used.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>17402369</pmid><doi>10.1177/0961203306075738</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 2007-01, Vol.16 (2), p.129-132 |
| issn | 0961-2033 1477-0962 |
| language | eng |
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| source | MEDLINE; SAGE Journals Online |
| subjects | Adult Age Antibodies Antibodies - blood Aspirin Autoimmune diseases Autoimmune Diseases - drug therapy Babies Clostridium tetani Connective tissue diseases Drug dosages Female Fetus - drug effects Humans Immune system Immunosuppressive agents Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Infant, Newborn Lupus Male Mothers Newborn babies Pregnancy Pregnancy Complications - drug therapy Tetanus Tetanus Toxoid - immunology |
| title | Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders |
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