Respiratory heat and moisture loss is associated with eosinophilic inflammation in asthma
Increased mucosal vascularity is a hallmark of airway inflammation in asthma. It was hypothesised that this would lead to a detectable increase in respiratory heat and moisture loss (RHML), which would reflect the degree of airway inflammation present. A total of 23 subjects with asthma and 18 healt...
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| Veröffentlicht in: | The European respiratory journal 2007-04, Vol.29 (4), p.676-681 |
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| container_title | The European respiratory journal |
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| creator | Noble, D. D McCafferty, J. B Greening, A. P Innes, J. A |
| description | Increased mucosal vascularity is a hallmark of airway inflammation in asthma. It was hypothesised that this would lead to a detectable increase in respiratory heat and moisture loss (RHML), which would reflect the degree of airway inflammation present. A total of 23 subjects with asthma and 18 healthy controls had RHML measured in a cross-sectional study. The measurements were made using a device that combines temperature and humidity measurement during inspiration and expiration and allows precise control over inspirate conditions and ventilatory pattern. The subjects with asthma underwent parallel measurements of exhaled nitric oxide, sputum eosinophil percentage and exhaled breath condensate pH. Mean+/-SD RHML was elevated in patients with asthma (98.1+/-7.3 J.L(-1)) compared with control subjects (91.9+/-4.5 J.L(-1)). RHML measurement in asthma correlated with sputum eosinophil percentage. This novel correlation between thermal and cellular measurements in asthma suggests that both of these noninvasive indices are sensitive to the degree of underlying chronic airway inflammation. |
| doi_str_mv | 10.1183/09031936.00071106 |
| format | Article |
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Mean+/-SD RHML was elevated in patients with asthma (98.1+/-7.3 J.L(-1)) compared with control subjects (91.9+/-4.5 J.L(-1)). RHML measurement in asthma correlated with sputum eosinophil percentage. 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The subjects with asthma underwent parallel measurements of exhaled nitric oxide, sputum eosinophil percentage and exhaled breath condensate pH. Mean+/-SD RHML was elevated in patients with asthma (98.1+/-7.3 J.L(-1)) compared with control subjects (91.9+/-4.5 J.L(-1)). RHML measurement in asthma correlated with sputum eosinophil percentage. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory heat and moisture loss is associated with eosinophilic inflammation in asthma</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>29</volume><issue>4</issue><spage>676</spage><epage>681</epage><pages>676-681</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Increased mucosal vascularity is a hallmark of airway inflammation in asthma. It was hypothesised that this would lead to a detectable increase in respiratory heat and moisture loss (RHML), which would reflect the degree of airway inflammation present. A total of 23 subjects with asthma and 18 healthy controls had RHML measured in a cross-sectional study. 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| ispartof | The European respiratory journal, 2007-04, Vol.29 (4), p.676-681 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Asthma - diagnosis Asthma - metabolism Biological and medical sciences Case-Control Studies Chronic obstructive pulmonary disease, asthma Eosinophils - metabolism Eosinophils - pathology Female Hot Temperature Humans Humidity Hydrogen-Ion Concentration Inflammation - complications Inflammation - diagnosis Male Medical sciences Middle Aged Nitric Oxide - metabolism Pneumology Respiratory Function Tests - instrumentation Respiratory Function Tests - methods Sputum - metabolism |
| title | Respiratory heat and moisture loss is associated with eosinophilic inflammation in asthma |
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