Association between inflammatory markers in induced sputum and clinical characteristics in children with non-cystic fibrosis bronchiectasis
To study clinical, radiological and laboratory features of children with non‐cystic fibrosis (non‐CF) bronchiectasis (BE) and the association between symptom scores, spirometry, high‐resolution computed tomography (HRCT) findings and inflammatory markers in induced sputum in these children. Twenty‐s...
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| Veröffentlicht in: | Pediatric pulmonology 2007-04, Vol.42 (4), p.362-369 |
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| creator | Guran, Tulay Ersu, Refika Karadag, Bulent Nuri Akpinar, Ihsan Yanikkaya Demirel, Gulderen Hekim, Nezih Dagli, Elif |
| description | To study clinical, radiological and laboratory features of children with non‐cystic fibrosis (non‐CF) bronchiectasis (BE) and the association between symptom scores, spirometry, high‐resolution computed tomography (HRCT) findings and inflammatory markers in induced sputum in these children. Twenty‐seven children with steady‐state non‐CF BE were cross‐sectionally evaluated by symptom scores, pulmonary function tests, anatomic extension and severity scores of BE in HRCT and tumor necrosis factor‐alpha (TNF‐α) and interleukin‐8 (IL‐8) levels in induced sputum. There were 16 girls and 11 boys. Median (interquartile range) age of study group was 11.4 (9.5–13.6) years, follow‐up duration was 3.5 (2–6.5) years and symptom scores were 4 (3–6). Pulmonary function tests revealed FEV1 of 82%pred (72–93), FVC of 82%pred (74–92), and FEF25–75% of 82%pred (68–95). According to anatomic extent of BE on HRCT; 2 patients had mild, 4 had moderate and 21 had severe BE. Based on severity scores of HRCT; 10 patients had mild, 10 had moderate and 7 had severe BE. Neutrophils consisted 29.9% (14.9–53.7) of the total leucocytes in induced sputum samples. Sputum concentration of TNF‐α was 58 pg/ml (9.2–302) while IL‐8 concentration was 2.7 ng/ml (1.7–2.8). Symptom scores correlated with FEV1 and sputum IL‐8 levels (r = −0.49, r = 0.67, P |
| doi_str_mv | 10.1002/ppul.20587 |
| format | Article |
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Twenty‐seven children with steady‐state non‐CF BE were cross‐sectionally evaluated by symptom scores, pulmonary function tests, anatomic extension and severity scores of BE in HRCT and tumor necrosis factor‐alpha (TNF‐α) and interleukin‐8 (IL‐8) levels in induced sputum. There were 16 girls and 11 boys. Median (interquartile range) age of study group was 11.4 (9.5–13.6) years, follow‐up duration was 3.5 (2–6.5) years and symptom scores were 4 (3–6). Pulmonary function tests revealed FEV1 of 82%pred (72–93), FVC of 82%pred (74–92), and FEF25–75% of 82%pred (68–95). According to anatomic extent of BE on HRCT; 2 patients had mild, 4 had moderate and 21 had severe BE. Based on severity scores of HRCT; 10 patients had mild, 10 had moderate and 7 had severe BE. Neutrophils consisted 29.9% (14.9–53.7) of the total leucocytes in induced sputum samples. Sputum concentration of TNF‐α was 58 pg/ml (9.2–302) while IL‐8 concentration was 2.7 ng/ml (1.7–2.8). Symptom scores correlated with FEV1 and sputum IL‐8 levels (r = −0.49, r = 0.67, P < 0.05). There was a significant correlation between HRCT severity scores and symptoms, FEV1, sputum IL‐8 and TNF‐α levels (r = 0.64, r = −0.68, r = 0.41, r = 0.41, respectively, P < 0.05). In children BE is associated with ongoing inflammation. This inflammation can be reliably monitored by radiological scores, spirometry, as well as sputum inflammatory markers. Follow‐up of children with BE using these clinical tools may improve patient care. Pediatr Pulmonol. 2007; 42:362–369. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.20587</identifier><identifier>PMID: 17351928</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Biological and medical sciences ; Biomarkers - metabolism ; bronchiectasis ; Bronchiectasis - metabolism ; Child ; children ; Cross-Sectional Studies ; Errors of metabolism ; Female ; Follow-Up Studies ; General aspects ; HRCT ; Humans ; IL-8 ; induced sputum ; Interleukin-8 - metabolism ; Male ; Medical sciences ; Metabolic diseases ; Miscellaneous hereditary metabolic disorders ; Neutrophils - metabolism ; Pneumology ; Respiratory Function Tests ; Respiratory system : syndromes and miscellaneous diseases ; Severity of Illness Index ; Sputum - metabolism ; TNF-α ; Tomography, X-Ray Computed ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Pediatric pulmonology, 2007-04, Vol.42 (4), p.362-369</ispartof><rights>Copyright © 2007 Wiley‐Liss, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3957-1bd568304db8f0ecd5ae5c8ae4867b935a3796302a8d4632722dd196c85e38dc3</citedby><cites>FETCH-LOGICAL-c3957-1bd568304db8f0ecd5ae5c8ae4867b935a3796302a8d4632722dd196c85e38dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.20587$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.20587$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18653405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17351928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guran, Tulay</creatorcontrib><creatorcontrib>Ersu, Refika</creatorcontrib><creatorcontrib>Karadag, Bulent</creatorcontrib><creatorcontrib>Nuri Akpinar, Ihsan</creatorcontrib><creatorcontrib>Yanikkaya Demirel, Gulderen</creatorcontrib><creatorcontrib>Hekim, Nezih</creatorcontrib><creatorcontrib>Dagli, Elif</creatorcontrib><title>Association between inflammatory markers in induced sputum and clinical characteristics in children with non-cystic fibrosis bronchiectasis</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>To study clinical, radiological and laboratory features of children with non‐cystic fibrosis (non‐CF) bronchiectasis (BE) and the association between symptom scores, spirometry, high‐resolution computed tomography (HRCT) findings and inflammatory markers in induced sputum in these children. Twenty‐seven children with steady‐state non‐CF BE were cross‐sectionally evaluated by symptom scores, pulmonary function tests, anatomic extension and severity scores of BE in HRCT and tumor necrosis factor‐alpha (TNF‐α) and interleukin‐8 (IL‐8) levels in induced sputum. There were 16 girls and 11 boys. Median (interquartile range) age of study group was 11.4 (9.5–13.6) years, follow‐up duration was 3.5 (2–6.5) years and symptom scores were 4 (3–6). Pulmonary function tests revealed FEV1 of 82%pred (72–93), FVC of 82%pred (74–92), and FEF25–75% of 82%pred (68–95). According to anatomic extent of BE on HRCT; 2 patients had mild, 4 had moderate and 21 had severe BE. Based on severity scores of HRCT; 10 patients had mild, 10 had moderate and 7 had severe BE. Neutrophils consisted 29.9% (14.9–53.7) of the total leucocytes in induced sputum samples. Sputum concentration of TNF‐α was 58 pg/ml (9.2–302) while IL‐8 concentration was 2.7 ng/ml (1.7–2.8). Symptom scores correlated with FEV1 and sputum IL‐8 levels (r = −0.49, r = 0.67, P < 0.05). There was a significant correlation between HRCT severity scores and symptoms, FEV1, sputum IL‐8 and TNF‐α levels (r = 0.64, r = −0.68, r = 0.41, r = 0.41, respectively, P < 0.05). In children BE is associated with ongoing inflammation. This inflammation can be reliably monitored by radiological scores, spirometry, as well as sputum inflammatory markers. Follow‐up of children with BE using these clinical tools may improve patient care. Pediatr Pulmonol. 2007; 42:362–369. © 2007 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>bronchiectasis</subject><subject>Bronchiectasis - metabolism</subject><subject>Child</subject><subject>children</subject><subject>Cross-Sectional Studies</subject><subject>Errors of metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>HRCT</subject><subject>Humans</subject><subject>IL-8</subject><subject>induced sputum</subject><subject>Interleukin-8 - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Miscellaneous hereditary metabolic disorders</subject><subject>Neutrophils - metabolism</subject><subject>Pneumology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Severity of Illness Index</subject><subject>Sputum - metabolism</subject><subject>TNF-α</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAQgC0EokvhwgMgX-CAlGLH8U-OpaIL0goqRNWj5dgTrSFxgu1o2WfgpfF2F3pDsjTyzDcz1meEXlJyQQmp383zMlzUhCv5CK0oaduKNK14jFZKcl4JJdgZepbSd0JKraVP0RmVjNO2Viv0-zKlyXqT_RRwB3kHELAP_WDG0eQp7vFo4g-IqSTLcYsFh9O85GXEJjhsBx-8NQO2WxONzRB9yt7e43brBxfLvJ3PWxymUNn9oYh738Up-YRLCIUCm025PkdPejMkeHGK5-j2-sO3q4_V5sv609XlprKs5bKineNCMdK4TvUErOMGuFUGGiVk1zJumGwFI7VRrhGslnXtHG2FVRyYcpadozfHuXOcfi6Qsh59sjAMJsC0JC0JqxVrWAHfHkFbnpsi9HqOvvjYa0r0Qb0-qNf36gv86jR16UZwD-jJdQFenwCTirE-mmB9euCU4KwhvHD0yO38APv_rNQ3N7ebv8urY0-xD7_-9ZSv00IyyfXd57Veq7v3X6-V0hv2BxYOrug</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Guran, Tulay</creator><creator>Ersu, Refika</creator><creator>Karadag, Bulent</creator><creator>Nuri Akpinar, Ihsan</creator><creator>Yanikkaya Demirel, Gulderen</creator><creator>Hekim, Nezih</creator><creator>Dagli, Elif</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>Association between inflammatory markers in induced sputum and clinical characteristics in children with non-cystic fibrosis bronchiectasis</title><author>Guran, Tulay ; Ersu, Refika ; Karadag, Bulent ; Nuri Akpinar, Ihsan ; Yanikkaya Demirel, Gulderen ; Hekim, Nezih ; Dagli, Elif</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3957-1bd568304db8f0ecd5ae5c8ae4867b935a3796302a8d4632722dd196c85e38dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>bronchiectasis</topic><topic>Bronchiectasis - metabolism</topic><topic>Child</topic><topic>children</topic><topic>Cross-Sectional Studies</topic><topic>Errors of metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>HRCT</topic><topic>Humans</topic><topic>IL-8</topic><topic>induced sputum</topic><topic>Interleukin-8 - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Miscellaneous hereditary metabolic disorders</topic><topic>Neutrophils - metabolism</topic><topic>Pneumology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Severity of Illness Index</topic><topic>Sputum - metabolism</topic><topic>TNF-α</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guran, Tulay</creatorcontrib><creatorcontrib>Ersu, Refika</creatorcontrib><creatorcontrib>Karadag, Bulent</creatorcontrib><creatorcontrib>Nuri Akpinar, Ihsan</creatorcontrib><creatorcontrib>Yanikkaya Demirel, Gulderen</creatorcontrib><creatorcontrib>Hekim, Nezih</creatorcontrib><creatorcontrib>Dagli, Elif</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guran, Tulay</au><au>Ersu, Refika</au><au>Karadag, Bulent</au><au>Nuri Akpinar, Ihsan</au><au>Yanikkaya Demirel, Gulderen</au><au>Hekim, Nezih</au><au>Dagli, Elif</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between inflammatory markers in induced sputum and clinical characteristics in children with non-cystic fibrosis bronchiectasis</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2007-04</date><risdate>2007</risdate><volume>42</volume><issue>4</issue><spage>362</spage><epage>369</epage><pages>362-369</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>To study clinical, radiological and laboratory features of children with non‐cystic fibrosis (non‐CF) bronchiectasis (BE) and the association between symptom scores, spirometry, high‐resolution computed tomography (HRCT) findings and inflammatory markers in induced sputum in these children. Twenty‐seven children with steady‐state non‐CF BE were cross‐sectionally evaluated by symptom scores, pulmonary function tests, anatomic extension and severity scores of BE in HRCT and tumor necrosis factor‐alpha (TNF‐α) and interleukin‐8 (IL‐8) levels in induced sputum. There were 16 girls and 11 boys. Median (interquartile range) age of study group was 11.4 (9.5–13.6) years, follow‐up duration was 3.5 (2–6.5) years and symptom scores were 4 (3–6). Pulmonary function tests revealed FEV1 of 82%pred (72–93), FVC of 82%pred (74–92), and FEF25–75% of 82%pred (68–95). According to anatomic extent of BE on HRCT; 2 patients had mild, 4 had moderate and 21 had severe BE. Based on severity scores of HRCT; 10 patients had mild, 10 had moderate and 7 had severe BE. Neutrophils consisted 29.9% (14.9–53.7) of the total leucocytes in induced sputum samples. Sputum concentration of TNF‐α was 58 pg/ml (9.2–302) while IL‐8 concentration was 2.7 ng/ml (1.7–2.8). Symptom scores correlated with FEV1 and sputum IL‐8 levels (r = −0.49, r = 0.67, P < 0.05). There was a significant correlation between HRCT severity scores and symptoms, FEV1, sputum IL‐8 and TNF‐α levels (r = 0.64, r = −0.68, r = 0.41, r = 0.41, respectively, P < 0.05). In children BE is associated with ongoing inflammation. This inflammation can be reliably monitored by radiological scores, spirometry, as well as sputum inflammatory markers. Follow‐up of children with BE using these clinical tools may improve patient care. Pediatr Pulmonol. 2007; 42:362–369. © 2007 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17351928</pmid><doi>10.1002/ppul.20587</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Biomarkers - metabolism bronchiectasis Bronchiectasis - metabolism Child children Cross-Sectional Studies Errors of metabolism Female Follow-Up Studies General aspects HRCT Humans IL-8 induced sputum Interleukin-8 - metabolism Male Medical sciences Metabolic diseases Miscellaneous hereditary metabolic disorders Neutrophils - metabolism Pneumology Respiratory Function Tests Respiratory system : syndromes and miscellaneous diseases Severity of Illness Index Sputum - metabolism TNF-α Tomography, X-Ray Computed Tumor Necrosis Factor-alpha - metabolism |
| title | Association between inflammatory markers in induced sputum and clinical characteristics in children with non-cystic fibrosis bronchiectasis |
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