Heme oxygenase inhibition by 2-oxy-substituted 1-(1 H-imidazol-1-yl)-4-phenylbutanes: Effect of halogen substitution in the phenyl ring

Novel, potent isoform-selective and non-selective inhibitors of heme oxygenase have been synthesized. A series of 2-oxy-substituted 1-(1 H-imidazol-1-yl)-4-phenylbutanes comprising imidazole–ketones, imidazole–dioxolanes, and imidazole–alcohols substituted with halogens in the phenyl ring were synth...

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