In vitro efficiency of new acridyl derivatives against Plasmodium falciparum
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC 50 ⩽ 0.20 μM. A series of new 9-substituted acridyl derivatives were synthesized and...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2007-05, Vol.15 (9), p.3278-3289 |
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| container_title | Bioorganic & medicinal chemistry |
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| creator | Guetzoyan, Lucie Ramiandrasoa, Florence Dorizon, Hélène Desprez, Christine Bridoux, Alexandre Rogier, Christophe Pradines, Bruno Perrée-Fauvet, Martine |
| description | A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against
Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC
50
⩽
0.20
μM.
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of
Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC
50
⩽
0.20
μM. |
| doi_str_mv | 10.1016/j.bmc.2007.02.022 |
| format | Article |
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Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC
50
⩽
0.20
μM.
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of
Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC
50
⩽
0.20
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Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC
50
⩽
0.20
μM.
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of
Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC
50
⩽
0.20
μM.</description><subject>Acridines - chemical synthesis</subject><subject>Acridines - chemistry</subject><subject>Acridines - pharmacology</subject><subject>Aminoacridine</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimalarial</subject><subject>Antimalarials - chemical synthesis</subject><subject>Antimalarials - chemistry</subject><subject>Antimalarials - pharmacology</subject><subject>Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Parasitic Sensitivity Tests</subject><subject>Peptidic synthesis</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Plasmodium falciparum - growth & development</subject><subject>Stereoisomerism</subject><subject>Structure-Activity Relationship</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlZ_gBfJRW9bk-xuNosnKX4UCnrQc8gmE0nZj5rsVvrvzdpCb8LAMPDMzMuD0DUlc0oov1_Pq0bPGSHFnLBY7ARNacazJE1LeoqmpOQiIaLkE3QRwpoQwrKSnqMJLUaCsilaLVu8db3vMFjrtINW73BncQs_WGnvzK7GBrzbqt5tIWD1pVwbevxeq9B0xg0NtqrWbqP80FyiszgEuDr0Gfp8fvpYvCart5fl4nGV6FTQPuGCcVMJVuSWZDqGtDbmsSIGFTbLq7ywmlNW5TY3OVPaWsFJHGlaMG2gTGfobn9347vvAUIvGxc01LVqoRuCLEjKeC5oBOke1L4LwYOVG-8a5XeSEjkqlGsZFcpRoSQsFos7N4fjQ9WAOW4cnEXg9gCooFVtvWq1C0dOjK_pmPJhz0FUsXXgZfjzC8Z50L00nfsnxi_BUo48</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Guetzoyan, Lucie</creator><creator>Ramiandrasoa, Florence</creator><creator>Dorizon, Hélène</creator><creator>Desprez, Christine</creator><creator>Bridoux, Alexandre</creator><creator>Rogier, Christophe</creator><creator>Pradines, Bruno</creator><creator>Perrée-Fauvet, Martine</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>In vitro efficiency of new acridyl derivatives against Plasmodium falciparum</title><author>Guetzoyan, Lucie ; Ramiandrasoa, Florence ; Dorizon, Hélène ; Desprez, Christine ; Bridoux, Alexandre ; Rogier, Christophe ; Pradines, Bruno ; Perrée-Fauvet, Martine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-6826db8275f04c096ff733f88968f45b57fc612b5f5d52acff8602b51372cde93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acridines - chemical synthesis</topic><topic>Acridines - chemistry</topic><topic>Acridines - pharmacology</topic><topic>Aminoacridine</topic><topic>Animals</topic><topic>Antibiotics. 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Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC
50
⩽
0.20
μM.
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of
Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC
50
⩽
0.20
μM.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17339112</pmid><doi>10.1016/j.bmc.2007.02.022</doi><tpages>12</tpages></addata></record> |
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| subjects | Acridines - chemical synthesis Acridines - chemistry Acridines - pharmacology Aminoacridine Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarial Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Antiparasitic agents Biological and medical sciences Medical sciences Molecular Structure Parasitic Sensitivity Tests Peptidic synthesis Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - growth & development Stereoisomerism Structure-Activity Relationship |
| title | In vitro efficiency of new acridyl derivatives against Plasmodium falciparum |
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