Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells

Lamellipodia formation necessary for cell invasion is regulated by Rac1. We report here that lamellipodia formation and three-dimensional invasion were significantly promoted by HGF and serum, respectively, in invasive human breast cancer cells. Rac1 formed a complex with CLIP-170, IQGAP1, and kines...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-04, Vol.368 (2), p.199-204
Hauptverfasser:	Suzuki, Katsuo, Takahashi, Kazuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - ultrastructure Cell invasion Cell Line, Tumor CLIP-170 Humans IQGAP1 Kinesin Kinesin - metabolism Lamellipodia Microtubule-Associated Proteins - metabolism Neoplasm Invasiveness - pathology Neoplasm Invasiveness - ultrastructure Neoplasm Proteins - metabolism Pseudopodia - metabolism Pseudopodia - ultrastructure Rac rac1 GTP-Binding Protein - metabolism ras GTPase-Activating Proteins - metabolism
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