POPC/apoA-I discs as a potent lipoprotein modulator in Tangier disease

Abstract Tangier disease (TD) is a rare familial disorder with mutations in the ATP-binding cassette transporter A1 (ABCA1) gene. It results in extremely low levels of HDL cholesterol. Since TD is a genetic disorder, a therapeutic approach to TD has not been established. We report a typical case of...

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Veröffentlicht in:	Atherosclerosis 2008-03, Vol.197 (1), p.283-289
Hauptverfasser:	Uehara, Yoshinari, Tsuboi, Yoshio, Zhang, Bo, Miura, Shin-ichiro, Baba, Yasuhiko, Higuchi, Masa-aki, Yamada, Tatsuo, Rye, Kerry-Anne, Saku, Keijiro
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 Apolipoprotein A-I Apolipoprotein A-I - pharmacology Apolipoproteins B - metabolism Apolipoproteins E - metabolism Atherosclerosis (general aspects, experimental research) ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cells, Cultured Cholesterol efflux Cholesterol Esters - metabolism Cholesterol, HDL - deficiency Cholesterol, HDL - metabolism Electrophoresis Humans Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Medical sciences Peripheral neuropathy Phosphatidylcholines - pharmacology Phospholipid Reconstituted HDL Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Tangier disease Tangier Disease - genetics Tangier Disease - metabolism Triglycerides - metabolism
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