Pigment epithelium-derived factor (PEDF) administration inhibits occlusive thrombus formation in rats: A possible participation of reduced intraplatelet PEDF in thrombosis of acute coronary syndromes

Abstract Objectives Although remarkable therapeutic advances in the treatment of acute coronary syndromes (ACS) have been made with anti-platelet therapy, the therapeutic options may be limited by considerable side effects. Pigment epithelium-derived factor (PEDF) has anti-oxidative properties and m...

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Veröffentlicht in:	Atherosclerosis 2008-03, Vol.197 (1), p.25-33
Hauptverfasser:	Takenaka, Katsuhiko, Yamagishi, Sho-ichi, Matsui, Takanori, Nakamura, Kazuo, Jinnouchi, Yuko, Yoshida, Yumiko, Ueda, Shin-ichiro, Katsuki, Yoshio, Katsuda, Yousuke, Imaizumi, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - drug therapy Acute Coronary Syndrome - metabolism Acute coronary syndromes Animals Arterial Occlusive Diseases - drug therapy Arterial Occlusive Diseases - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Platelets - drug effects Blood Platelets - metabolism Cardiology. Vascular system Cardiovascular Carotid Artery Thrombosis - drug therapy Carotid Artery Thrombosis - metabolism Coronary heart disease Disease Models, Animal Dose-Response Relationship, Drug Eye Proteins - metabolism Eye Proteins - pharmacology Heart Humans Medical sciences NADPH Oxidases - metabolism Nerve Growth Factors - metabolism Nerve Growth Factors - pharmacology P-Selectin - metabolism Pigment epithelium-derived factor Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation - physiology Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Serpins - metabolism Serpins - pharmacology Superoxides - metabolism Thrombosis
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