Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents
Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8‐year longitudinal study of children (n = 183). Half of the children met criteria for attention‐deficit/hyperactivity disorder (ADHD) at 4–6 years and half...
Gespeichert in:
| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-04, Vol.144B (3), p.310-317 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 317 |
|---|---|
| container_issue | 3 |
| container_start_page | 310 |
| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
| container_volume | 144B |
| creator | Lee, Steve S. Lahey, Benjamin B. Waldman, Irwin Van Hulle, Carol A. Rathouz, Paul Pelham, William E. Loney, Jan Cook, Edwin H. |
| description | Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8‐year longitudinal study of children (n = 183). Half of the children met criteria for attention‐deficit/hyperactivity disorder (ADHD) at 4–6 years and half were non‐referred comparison children. Consistent with several studies, the non‐additive association for the 10‐repeat allele was significant for hyperactivity‐impulsivity (HI) symptoms. However, consistent with other studies, exploratory analyses of the non‐additive association of the 9‐repeat allele of DAT1 with HI and oppositional defiant disorder (ODD) symptoms also were significant. The inconsistent association between DAT1 and child behavior problems in this and other samples may reflect joint influence of the 10‐repeat and 9‐repeat alleles. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.b.30447 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70324756</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20298348</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4327-2bec3224eeedbc8093403a66abb6f1e6e642a0dea29299439a3e19b171daf1b33</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhiMEoh9w44x8gVOz-CtxclxVsIDacgFRcbEm8WTXJYmD7bTkV_CXSdilvcHJI-uZeWf0JMkLRleMUv4GbrrtqloJKqV6lByzLOOpLLLrx_e1ZEfJSQg3lAqaKfU0OWKKlbzMsuPk1zoEV1uI1vXENcS4ATrbI4ke-jA4H9GTLfYuTgOSOxt3xNjgxyHaWyQV7uDWOr_8OW_QB2J7Aj1Bu93FdELwpHX91sbR2B5aEuZiWnLqnW2NxwU2BIxrMdTYx_AsedJAG_D54T1Nvrx7-_n8fXrxafPhfH2R1lJwlfIKa8G5RERT1QUthaQC8hyqKm8Y5phLDtQg8PnOUooSBLKymu820LBKiNPk9X7u4N2PEUPUnZ03aFvo0Y1BKyq4VFn-X5BTXhZCFjN4tgdr70Lw2OjB2w78pBnViym9mNKV_mNqxl8e5o5Vh-YBPqiZgVcHAEINbTP7qG144IpcybxccsWeu7MtTv8M1euPl5u_8em-y4aIP--7wH_XuRIq01-vNlpl1-WGX33Tl-I3-ci_2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20298348</pqid></control><display><type>article</type><title>Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Lee, Steve S. ; Lahey, Benjamin B. ; Waldman, Irwin ; Van Hulle, Carol A. ; Rathouz, Paul ; Pelham, William E. ; Loney, Jan ; Cook, Edwin H.</creator><creatorcontrib>Lee, Steve S. ; Lahey, Benjamin B. ; Waldman, Irwin ; Van Hulle, Carol A. ; Rathouz, Paul ; Pelham, William E. ; Loney, Jan ; Cook, Edwin H.</creatorcontrib><description>Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8‐year longitudinal study of children (n = 183). Half of the children met criteria for attention‐deficit/hyperactivity disorder (ADHD) at 4–6 years and half were non‐referred comparison children. Consistent with several studies, the non‐additive association for the 10‐repeat allele was significant for hyperactivity‐impulsivity (HI) symptoms. However, consistent with other studies, exploratory analyses of the non‐additive association of the 9‐repeat allele of DAT1 with HI and oppositional defiant disorder (ODD) symptoms also were significant. The inconsistent association between DAT1 and child behavior problems in this and other samples may reflect joint influence of the 10‐repeat and 9‐repeat alleles. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.30447</identifier><identifier>PMID: 17192955</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Attention ; Attention Deficit and Disruptive Behavior Disorders - ethnology ; Attention Deficit and Disruptive Behavior Disorders - genetics ; attention-deficit/hyperactivity disorder (ADHD) ; Biological and medical sciences ; Case-Control Studies ; Child ; Child, Preschool ; conduct disorder (CD) ; dopamine ; Dopamine Plasma Membrane Transport Proteins - genetics ; Female ; Gene Frequency ; Genetic Linkage ; genetics ; Genotype ; Humans ; Longitudinal Studies ; Male ; Medical genetics ; Medical sciences ; Minisatellite Repeats - genetics ; oppositional defiant disorder (ODD) ; Polymorphism, Genetic</subject><ispartof>American journal of medical genetics. Part B, Neuropsychiatric genetics, 2007-04, Vol.144B (3), p.310-317</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2007 INIST-CNRS</rights><rights>(c) 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4327-2bec3224eeedbc8093403a66abb6f1e6e642a0dea29299439a3e19b171daf1b33</citedby><cites>FETCH-LOGICAL-c4327-2bec3224eeedbc8093403a66abb6f1e6e642a0dea29299439a3e19b171daf1b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajmg.b.30447$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajmg.b.30447$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18674698$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17192955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Steve S.</creatorcontrib><creatorcontrib>Lahey, Benjamin B.</creatorcontrib><creatorcontrib>Waldman, Irwin</creatorcontrib><creatorcontrib>Van Hulle, Carol A.</creatorcontrib><creatorcontrib>Rathouz, Paul</creatorcontrib><creatorcontrib>Pelham, William E.</creatorcontrib><creatorcontrib>Loney, Jan</creatorcontrib><creatorcontrib>Cook, Edwin H.</creatorcontrib><title>Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents</title><title>American journal of medical genetics. Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8‐year longitudinal study of children (n = 183). Half of the children met criteria for attention‐deficit/hyperactivity disorder (ADHD) at 4–6 years and half were non‐referred comparison children. Consistent with several studies, the non‐additive association for the 10‐repeat allele was significant for hyperactivity‐impulsivity (HI) symptoms. However, consistent with other studies, exploratory analyses of the non‐additive association of the 9‐repeat allele of DAT1 with HI and oppositional defiant disorder (ODD) symptoms also were significant. The inconsistent association between DAT1 and child behavior problems in this and other samples may reflect joint influence of the 10‐repeat and 9‐repeat alleles. © 2006 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Attention</subject><subject>Attention Deficit and Disruptive Behavior Disorders - ethnology</subject><subject>Attention Deficit and Disruptive Behavior Disorders - genetics</subject><subject>attention-deficit/hyperactivity disorder (ADHD)</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>conduct disorder (CD)</subject><subject>dopamine</subject><subject>Dopamine Plasma Membrane Transport Proteins - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Linkage</subject><subject>genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Minisatellite Repeats - genetics</subject><subject>oppositional defiant disorder (ODD)</subject><subject>Polymorphism, Genetic</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoh9w44x8gVOz-CtxclxVsIDacgFRcbEm8WTXJYmD7bTkV_CXSdilvcHJI-uZeWf0JMkLRleMUv4GbrrtqloJKqV6lByzLOOpLLLrx_e1ZEfJSQg3lAqaKfU0OWKKlbzMsuPk1zoEV1uI1vXENcS4ATrbI4ke-jA4H9GTLfYuTgOSOxt3xNjgxyHaWyQV7uDWOr_8OW_QB2J7Aj1Bu93FdELwpHX91sbR2B5aEuZiWnLqnW2NxwU2BIxrMdTYx_AsedJAG_D54T1Nvrx7-_n8fXrxafPhfH2R1lJwlfIKa8G5RERT1QUthaQC8hyqKm8Y5phLDtQg8PnOUooSBLKymu820LBKiNPk9X7u4N2PEUPUnZ03aFvo0Y1BKyq4VFn-X5BTXhZCFjN4tgdr70Lw2OjB2w78pBnViym9mNKV_mNqxl8e5o5Vh-YBPqiZgVcHAEINbTP7qG144IpcybxccsWeu7MtTv8M1euPl5u_8em-y4aIP--7wH_XuRIq01-vNlpl1-WGX33Tl-I3-ci_2A</recordid><startdate>20070405</startdate><enddate>20070405</enddate><creator>Lee, Steve S.</creator><creator>Lahey, Benjamin B.</creator><creator>Waldman, Irwin</creator><creator>Van Hulle, Carol A.</creator><creator>Rathouz, Paul</creator><creator>Pelham, William E.</creator><creator>Loney, Jan</creator><creator>Cook, Edwin H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070405</creationdate><title>Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents</title><author>Lee, Steve S. ; Lahey, Benjamin B. ; Waldman, Irwin ; Van Hulle, Carol A. ; Rathouz, Paul ; Pelham, William E. ; Loney, Jan ; Cook, Edwin H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4327-2bec3224eeedbc8093403a66abb6f1e6e642a0dea29299439a3e19b171daf1b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Attention</topic><topic>Attention Deficit and Disruptive Behavior Disorders - ethnology</topic><topic>Attention Deficit and Disruptive Behavior Disorders - genetics</topic><topic>attention-deficit/hyperactivity disorder (ADHD)</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>conduct disorder (CD)</topic><topic>dopamine</topic><topic>Dopamine Plasma Membrane Transport Proteins - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Linkage</topic><topic>genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Minisatellite Repeats - genetics</topic><topic>oppositional defiant disorder (ODD)</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Steve S.</creatorcontrib><creatorcontrib>Lahey, Benjamin B.</creatorcontrib><creatorcontrib>Waldman, Irwin</creatorcontrib><creatorcontrib>Van Hulle, Carol A.</creatorcontrib><creatorcontrib>Rathouz, Paul</creatorcontrib><creatorcontrib>Pelham, William E.</creatorcontrib><creatorcontrib>Loney, Jan</creatorcontrib><creatorcontrib>Cook, Edwin H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Steve S.</au><au>Lahey, Benjamin B.</au><au>Waldman, Irwin</au><au>Van Hulle, Carol A.</au><au>Rathouz, Paul</au><au>Pelham, William E.</au><au>Loney, Jan</au><au>Cook, Edwin H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents</atitle><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2007-04-05</date><risdate>2007</risdate><volume>144B</volume><issue>3</issue><spage>310</spage><epage>317</epage><pages>310-317</pages><issn>1552-4841</issn><eissn>1552-485X</eissn><abstract>Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8‐year longitudinal study of children (n = 183). Half of the children met criteria for attention‐deficit/hyperactivity disorder (ADHD) at 4–6 years and half were non‐referred comparison children. Consistent with several studies, the non‐additive association for the 10‐repeat allele was significant for hyperactivity‐impulsivity (HI) symptoms. However, consistent with other studies, exploratory analyses of the non‐additive association of the 9‐repeat allele of DAT1 with HI and oppositional defiant disorder (ODD) symptoms also were significant. The inconsistent association between DAT1 and child behavior problems in this and other samples may reflect joint influence of the 10‐repeat and 9‐repeat alleles. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17192955</pmid><doi>10.1002/ajmg.b.30447</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-4841 |
| ispartof | American journal of medical genetics. Part B, Neuropsychiatric genetics, 2007-04, Vol.144B (3), p.310-317 |
| issn | 1552-4841 1552-485X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70324756 |
| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Attention Attention Deficit and Disruptive Behavior Disorders - ethnology Attention Deficit and Disruptive Behavior Disorders - genetics attention-deficit/hyperactivity disorder (ADHD) Biological and medical sciences Case-Control Studies Child Child, Preschool conduct disorder (CD) dopamine Dopamine Plasma Membrane Transport Proteins - genetics Female Gene Frequency Genetic Linkage genetics Genotype Humans Longitudinal Studies Male Medical genetics Medical sciences Minisatellite Repeats - genetics oppositional defiant disorder (ODD) Polymorphism, Genetic |
| title | Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T21%3A13%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20dopamine%20transporter%20genotype%20with%20disruptive%20behavior%20disorders%20in%20an%20eight-year%20longitudinal%20study%20of%20children%20and%20adolescents&rft.jtitle=American%20journal%20of%20medical%20genetics.%20Part%20B,%20Neuropsychiatric%20genetics&rft.au=Lee,%20Steve%20S.&rft.date=2007-04-05&rft.volume=144B&rft.issue=3&rft.spage=310&rft.epage=317&rft.pages=310-317&rft.issn=1552-4841&rft.eissn=1552-485X&rft_id=info:doi/10.1002/ajmg.b.30447&rft_dat=%3Cproquest_cross%3E20298348%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20298348&rft_id=info:pmid/17192955&rfr_iscdi=true |