Linkage of schizophrenia with chromosome 1q32 in Korean multiplex families
Chromosome 1q contains a few loci for which modest evidence of linkage with schizophrenia has been reported in several independent studies. However, markers showing the peak linkage signal are dispersed over a large chromosomal region. In addition, inconsistent findings have been generated from diff...
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| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-04, Vol.144B (3), p.279-284 |
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| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
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| creator | Jang, Yong Lee Kim, Jong Won Lee, Yu-Sang Park, Dong Yeon Cho, Eun-Young Jeun, Hyun Ok Lee, Dongsoo Hong, Kyung Sue |
| description | Chromosome 1q contains a few loci for which modest evidence of linkage with schizophrenia has been reported in several independent studies. However, markers showing the peak linkage signal are dispersed over a large chromosomal region. In addition, inconsistent findings have been generated from different populations or different subgroups of the same populations. The purpose of the current study is to determine whether those loci are linked to schizophrenia in the Korean population. We investigated 46 Korean multiplex schizophrenia families, initially using 11 microsatellite markers spanning around 91 cM region of 1p22∼42. In a non‐parametric linkage analysis, D1S249 located on 1q32.1 showed statistical evidence suggestive of linkage. At the second stage analysis for narrowing down the region, four additional nearby markers were genotyped. In the single point analysis, we found another suggestive linkage signal at D1S2891. The highest NPL score of 2.67 (P = 0.0039) was obtained in the multi‐point analysis. This study provides supportive evidence for linkage of chromosome 1q32 with schizophrenia. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.b.30389 |
| format | Article |
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However, markers showing the peak linkage signal are dispersed over a large chromosomal region. In addition, inconsistent findings have been generated from different populations or different subgroups of the same populations. The purpose of the current study is to determine whether those loci are linked to schizophrenia in the Korean population. We investigated 46 Korean multiplex schizophrenia families, initially using 11 microsatellite markers spanning around 91 cM region of 1p22∼42. In a non‐parametric linkage analysis, D1S249 located on 1q32.1 showed statistical evidence suggestive of linkage. At the second stage analysis for narrowing down the region, four additional nearby markers were genotyped. In the single point analysis, we found another suggestive linkage signal at D1S2891. The highest NPL score of 2.67 (P = 0.0039) was obtained in the multi‐point analysis. This study provides supportive evidence for linkage of chromosome 1q32 with schizophrenia. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.30389</identifier><identifier>PMID: 17171664</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>chromosome 1 ; Chromosomes, Human, Pair 1 ; Family ; Genetic Linkage ; genetic study ; Genotype ; Humans ; Korea ; linkage analysis ; Lod Score ; Microsatellite Repeats ; schizophrenia ; Schizophrenia - genetics</subject><ispartof>American journal of medical genetics. 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Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Chromosome 1q contains a few loci for which modest evidence of linkage with schizophrenia has been reported in several independent studies. However, markers showing the peak linkage signal are dispersed over a large chromosomal region. In addition, inconsistent findings have been generated from different populations or different subgroups of the same populations. The purpose of the current study is to determine whether those loci are linked to schizophrenia in the Korean population. We investigated 46 Korean multiplex schizophrenia families, initially using 11 microsatellite markers spanning around 91 cM region of 1p22∼42. In a non‐parametric linkage analysis, D1S249 located on 1q32.1 showed statistical evidence suggestive of linkage. At the second stage analysis for narrowing down the region, four additional nearby markers were genotyped. In the single point analysis, we found another suggestive linkage signal at D1S2891. The highest NPL score of 2.67 (P = 0.0039) was obtained in the multi‐point analysis. This study provides supportive evidence for linkage of chromosome 1q32 with schizophrenia. © 2006 Wiley‐Liss, Inc.</description><subject>chromosome 1</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Family</subject><subject>Genetic Linkage</subject><subject>genetic study</subject><subject>Genotype</subject><subject>Humans</subject><subject>Korea</subject><subject>linkage analysis</subject><subject>Lod Score</subject><subject>Microsatellite Repeats</subject><subject>schizophrenia</subject><subject>Schizophrenia - genetics</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP6zAQRi0E4r276yuv7ooUOxPb8RIqKI8CQgLBznKSCTUkcbFb8fj1tLTA7qJZzCzO90lzCPnDWY8zlu7bx_ahV_SAQa5XyCYXIk2yXNyvft8Z3yBbMT4yBkwotU42uJqNlNkmORu67sk-IPU1jeXIvfvxKGDnLH1xkxEtR8G3PvoWKX-GlLqOnvuAtqPttJm4cYOvtLataxzGHbJW2ybi7nJvk9vjo5v-STK8Gpz2D4ZJmbFUJ1rKQpSSCaYQseJQlTmUOaa6ENLq2UsCbKG1VVWRKawQ6lqDkrkGIWSVwTb5t-gdB_88xTgxrYslNo3t0E-jUQzSDDj7FeRagRRqDu4twDL4GAPWZhxca8Ob4czMJZu5ZFOYT8kz_O-yd1q0WP3AS6szABbAi2vw7b9l5uDsYvBVmyxSLk7w9Ttlw5ORCpQwd5cDk_NDpg_ZtVHwASV3lpc</recordid><startdate>20070405</startdate><enddate>20070405</enddate><creator>Jang, Yong Lee</creator><creator>Kim, Jong Won</creator><creator>Lee, Yu-Sang</creator><creator>Park, Dong Yeon</creator><creator>Cho, Eun-Young</creator><creator>Jeun, Hyun Ok</creator><creator>Lee, Dongsoo</creator><creator>Hong, Kyung Sue</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070405</creationdate><title>Linkage of schizophrenia with chromosome 1q32 in Korean multiplex families</title><author>Jang, Yong Lee ; Kim, Jong Won ; Lee, Yu-Sang ; Park, Dong Yeon ; Cho, Eun-Young ; Jeun, Hyun Ok ; Lee, Dongsoo ; Hong, Kyung Sue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4029-966b5c60507eeed13dc83c8e29b56a900253ab99a7db47ede3ff9376893556d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>chromosome 1</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Family</topic><topic>Genetic Linkage</topic><topic>genetic study</topic><topic>Genotype</topic><topic>Humans</topic><topic>Korea</topic><topic>linkage analysis</topic><topic>Lod Score</topic><topic>Microsatellite Repeats</topic><topic>schizophrenia</topic><topic>Schizophrenia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Yong Lee</creatorcontrib><creatorcontrib>Kim, Jong Won</creatorcontrib><creatorcontrib>Lee, Yu-Sang</creatorcontrib><creatorcontrib>Park, Dong Yeon</creatorcontrib><creatorcontrib>Cho, Eun-Young</creatorcontrib><creatorcontrib>Jeun, Hyun Ok</creatorcontrib><creatorcontrib>Lee, Dongsoo</creatorcontrib><creatorcontrib>Hong, Kyung Sue</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Yong Lee</au><au>Kim, Jong Won</au><au>Lee, Yu-Sang</au><au>Park, Dong Yeon</au><au>Cho, Eun-Young</au><au>Jeun, Hyun Ok</au><au>Lee, Dongsoo</au><au>Hong, Kyung Sue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linkage of schizophrenia with chromosome 1q32 in Korean multiplex families</atitle><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2007-04-05</date><risdate>2007</risdate><volume>144B</volume><issue>3</issue><spage>279</spage><epage>284</epage><pages>279-284</pages><issn>1552-4841</issn><eissn>1552-485X</eissn><abstract>Chromosome 1q contains a few loci for which modest evidence of linkage with schizophrenia has been reported in several independent studies. However, markers showing the peak linkage signal are dispersed over a large chromosomal region. In addition, inconsistent findings have been generated from different populations or different subgroups of the same populations. The purpose of the current study is to determine whether those loci are linked to schizophrenia in the Korean population. We investigated 46 Korean multiplex schizophrenia families, initially using 11 microsatellite markers spanning around 91 cM region of 1p22∼42. In a non‐parametric linkage analysis, D1S249 located on 1q32.1 showed statistical evidence suggestive of linkage. At the second stage analysis for narrowing down the region, four additional nearby markers were genotyped. In the single point analysis, we found another suggestive linkage signal at D1S2891. The highest NPL score of 2.67 (P = 0.0039) was obtained in the multi‐point analysis. This study provides supportive evidence for linkage of chromosome 1q32 with schizophrenia. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17171664</pmid><doi>10.1002/ajmg.b.30389</doi><tpages>6</tpages></addata></record> |
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| subjects | chromosome 1 Chromosomes, Human, Pair 1 Family Genetic Linkage genetic study Genotype Humans Korea linkage analysis Lod Score Microsatellite Repeats schizophrenia Schizophrenia - genetics |
| title | Linkage of schizophrenia with chromosome 1q32 in Korean multiplex families |
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