C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells

During apoptosis, the dying cell activates an intrinsic mechanism that quickly dismantles itself. The apoptotic cell corpses are then recognized and removed by neighboring cells or professional phagocytes. How dying cells are degraded after internalization is poorly understood. Here, we report the i...

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Veröffentlicht in:	Development (Cambridge) 2008-03, Vol.135 (6), p.1069-1080
Hauptverfasser:	Lu, Qun, Zhang, Yan, Hu, Tianjing, Guo, Pengfei, Li, Weida, Wang, Xiaochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Animals, Genetically Modified Apoptosis - physiology Caenorhabditis elegans Caenorhabditis elegans - cytology Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - antagonists & inhibitors Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Egg Proteins - genetics Egg Proteins - metabolism Endocytosis - physiology Female Gene Expression Genes, Helminth Lysosomes - metabolism Membrane Glycoproteins - metabolism Mutation Phagosomes - metabolism rab GTP-Binding Proteins - antagonists & inhibitors rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism rab5 GTP-Binding Proteins - metabolism RNA Interference
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