Ionic mechanisms underlying the positive chronotropy induced by beta1-adrenergic stimulation in guinea pig sinoatrial node cells: a simulation study

Positive chronotropy induced by beta1-adrenergic stimulation is achieved by multiple interactions of ion channels and transporters in sinoatrial node pacemaker cells (SANs). To investigate the ionic mechanisms, we updated our SAN model developed in 2003 and incorporated the beta1-adrenergic signalin...

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Veröffentlicht in:	The journal of physiological sciences 2008-02, Vol.58 (1), p.53-65
Hauptverfasser:	Himeno, Yukiko, Sarai, Nobuaki, Matsuoka, Satoshi, Noma, Akinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Biological Clocks - physiology Calcium - metabolism Computer Simulation Guinea Pigs Heart Rate - physiology Models, Biological Receptors, Adrenergic, beta-1 - physiology Signal Transduction - physiology Sinoatrial Node - cytology Sinoatrial Node - physiology Sympathetic Nervous System - physiology
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