Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: the role of erythropoietic growth factors
Background: The objectives of the present study were to evaluate hemoglobin levels and consequent clinical behaviors related to anemia developed in patients affected by locally advanced cervical cancer treated with neo-adjuvant chemotherapy in the last decade and to evaluate the impact that the intr...
Gespeichert in:
| Veröffentlicht in: | Annals of oncology 2007-04, Vol.18 (4), p.722-729 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 729 |
|---|---|
| container_issue | 4 |
| container_start_page | 722 |
| container_title | Annals of oncology |
| container_volume | 18 |
| creator | Bellati, F Pernice, M Manci, N Palaia, I Tomao, F Marchetti, C Zullo, MA Muzii, L Angioli, R Panici, P. Benedeth |
| description | Background: The objectives of the present study were to evaluate hemoglobin levels and consequent clinical behaviors related to anemia developed in patients affected by locally advanced cervical cancer treated with neo-adjuvant chemotherapy in the last decade and to evaluate the impact that the introduction of erythropoietic growth factors had in the clinical practice. Patients and methods: Blood chemistries, prospectively recorded from 98 cervical cancer patients, treated with neo-adjuvant chemotherapy and, if necessary, erythropoietic growth factors, were compared with matched historical controls before the introduction of growth factors in clinical practice. Results: Hemoglobin level in the study group did not differ significantly during chemotherapy. At the third cycle of chemotherapy and at the end of chemotherapy, hemoglobin level was significantly higher in the study group compared with the control group. Transfusion rates in the study group were significantly lower. The analysis within the study group revealed that hemoglobin level in patients who suffer at diagnosis from anemia tends to increase whereas hemoglobin level in nonanemic patients tends to decrease. Conclusions: Erythropoietic growth factors increase hemoglobin level and reduce blood transfusions in cervical cancer patients undergoing neo-adjuvant chemotherapy followed by radical surgery. An appropriate autologous blood donation program can noticeably reduce homologous blood transfusions. |
| doi_str_mv | 10.1093/annonc/mdl491 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70320604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1250424101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-4b3bf1975dccf71d9b561e6ca60c19b04350350b3b81b01d6e92388e770cf9e83</originalsourceid><addsrcrecordid>eNpdkl2LEzEUhgdR3Fq99FaCoHfjJs3MZOKdu6gVFgU_YPEmZPLRpqbJmGS69of6fzy1xYIQCHnz5M3JeVNVTwl-RTCnlzKEGNTlVvuGk3vVjLQdr3vckPvVDPMFrVlLm4vqUc4bjHHHF_xhdUEYxYy1_az6vTTbuPJxcAHtZHKyuBiQDBoNPkaNSpIh2ykf1CSLyQjAESgTSkbSWqOKAXiPfFTS-z2SeieDAk2ZtHOgIXVYJzQFbdIqurBCwcRa6s0EZEFqDSWUtUly3CMbvY93R8ck9d_zeUork_avEUAoRW9QtAiEsk5xjM4Up9AqxbuyRlaqElN-XD2w0mfz5DTPq2_v3n69XtY3n95_uH5zU6tm0Za6GehgCWetVsoyovnQdsR0SnZYET7ghrYYBlA9GTDRnYGG9r1hDCvLTU_n1cuj75jiz8nkIrYuK-O9hBdOWTBMF7gDn3n1_D9wE6cUoDZBeNc1GFIDqD5CKsWck7FiTG4r014QLA5hi2PY4hg28M9OptOwNfpMn9IF4MUJkBkaaSFL5fKZ6-E7AHq-2OVifv3bl-mH6BhlrVjefhdfbuln2ny8Elf0D99ayfw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>196640569</pqid></control><display><type>article</type><title>Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: the role of erythropoietic growth factors</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Bellati, F ; Pernice, M ; Manci, N ; Palaia, I ; Tomao, F ; Marchetti, C ; Zullo, MA ; Muzii, L ; Angioli, R ; Panici, P. Benedeth</creator><creatorcontrib>Bellati, F ; Pernice, M ; Manci, N ; Palaia, I ; Tomao, F ; Marchetti, C ; Zullo, MA ; Muzii, L ; Angioli, R ; Panici, P. Benedeth</creatorcontrib><description>Background: The objectives of the present study were to evaluate hemoglobin levels and consequent clinical behaviors related to anemia developed in patients affected by locally advanced cervical cancer treated with neo-adjuvant chemotherapy in the last decade and to evaluate the impact that the introduction of erythropoietic growth factors had in the clinical practice. Patients and methods: Blood chemistries, prospectively recorded from 98 cervical cancer patients, treated with neo-adjuvant chemotherapy and, if necessary, erythropoietic growth factors, were compared with matched historical controls before the introduction of growth factors in clinical practice. Results: Hemoglobin level in the study group did not differ significantly during chemotherapy. At the third cycle of chemotherapy and at the end of chemotherapy, hemoglobin level was significantly higher in the study group compared with the control group. Transfusion rates in the study group were significantly lower. The analysis within the study group revealed that hemoglobin level in patients who suffer at diagnosis from anemia tends to increase whereas hemoglobin level in nonanemic patients tends to decrease. Conclusions: Erythropoietic growth factors increase hemoglobin level and reduce blood transfusions in cervical cancer patients undergoing neo-adjuvant chemotherapy followed by radical surgery. An appropriate autologous blood donation program can noticeably reduce homologous blood transfusions.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdl491</identifier><identifier>PMID: 17307758</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Anemia - therapy ; Antineoplastic agents ; Biological and medical sciences ; Blood Transfusion - statistics & numerical data ; blood transfusions ; Cervical cancer ; Chemotherapy, Adjuvant ; erythropoietic growth factors ; Erythropoietin - therapeutic use ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Hemoglobins - analysis ; Humans ; locally advanced cervical cancer ; Medical sciences ; Middle Aged ; neo-adjuvant chemotherapy ; Neoadjuvant Therapy ; Pharmacology. Drug treatments ; Tumors ; Uterine Cervical Neoplasms - blood ; Uterine Cervical Neoplasms - complications ; Uterine Cervical Neoplasms - therapy</subject><ispartof>Annals of oncology, 2007-04, Vol.18 (4), p.722-729</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright Springer Science & Business Media Apr 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-4b3bf1975dccf71d9b561e6ca60c19b04350350b3b81b01d6e92388e770cf9e83</citedby><cites>FETCH-LOGICAL-c425t-4b3bf1975dccf71d9b561e6ca60c19b04350350b3b81b01d6e92388e770cf9e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18692307$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17307758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellati, F</creatorcontrib><creatorcontrib>Pernice, M</creatorcontrib><creatorcontrib>Manci, N</creatorcontrib><creatorcontrib>Palaia, I</creatorcontrib><creatorcontrib>Tomao, F</creatorcontrib><creatorcontrib>Marchetti, C</creatorcontrib><creatorcontrib>Zullo, MA</creatorcontrib><creatorcontrib>Muzii, L</creatorcontrib><creatorcontrib>Angioli, R</creatorcontrib><creatorcontrib>Panici, P. Benedeth</creatorcontrib><title>Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: the role of erythropoietic growth factors</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Background: The objectives of the present study were to evaluate hemoglobin levels and consequent clinical behaviors related to anemia developed in patients affected by locally advanced cervical cancer treated with neo-adjuvant chemotherapy in the last decade and to evaluate the impact that the introduction of erythropoietic growth factors had in the clinical practice. Patients and methods: Blood chemistries, prospectively recorded from 98 cervical cancer patients, treated with neo-adjuvant chemotherapy and, if necessary, erythropoietic growth factors, were compared with matched historical controls before the introduction of growth factors in clinical practice. Results: Hemoglobin level in the study group did not differ significantly during chemotherapy. At the third cycle of chemotherapy and at the end of chemotherapy, hemoglobin level was significantly higher in the study group compared with the control group. Transfusion rates in the study group were significantly lower. The analysis within the study group revealed that hemoglobin level in patients who suffer at diagnosis from anemia tends to increase whereas hemoglobin level in nonanemic patients tends to decrease. Conclusions: Erythropoietic growth factors increase hemoglobin level and reduce blood transfusions in cervical cancer patients undergoing neo-adjuvant chemotherapy followed by radical surgery. An appropriate autologous blood donation program can noticeably reduce homologous blood transfusions.</description><subject>Adult</subject><subject>Aged</subject><subject>Anemia - therapy</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion - statistics & numerical data</subject><subject>blood transfusions</subject><subject>Cervical cancer</subject><subject>Chemotherapy, Adjuvant</subject><subject>erythropoietic growth factors</subject><subject>Erythropoietin - therapeutic use</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>locally advanced cervical cancer</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>neo-adjuvant chemotherapy</subject><subject>Neoadjuvant Therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - blood</subject><subject>Uterine Cervical Neoplasms - complications</subject><subject>Uterine Cervical Neoplasms - therapy</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkl2LEzEUhgdR3Fq99FaCoHfjJs3MZOKdu6gVFgU_YPEmZPLRpqbJmGS69of6fzy1xYIQCHnz5M3JeVNVTwl-RTCnlzKEGNTlVvuGk3vVjLQdr3vckPvVDPMFrVlLm4vqUc4bjHHHF_xhdUEYxYy1_az6vTTbuPJxcAHtZHKyuBiQDBoNPkaNSpIh2ykf1CSLyQjAESgTSkbSWqOKAXiPfFTS-z2SeieDAk2ZtHOgIXVYJzQFbdIqurBCwcRa6s0EZEFqDSWUtUly3CMbvY93R8ck9d_zeUork_avEUAoRW9QtAiEsk5xjM4Up9AqxbuyRlaqElN-XD2w0mfz5DTPq2_v3n69XtY3n95_uH5zU6tm0Za6GehgCWetVsoyovnQdsR0SnZYET7ghrYYBlA9GTDRnYGG9r1hDCvLTU_n1cuj75jiz8nkIrYuK-O9hBdOWTBMF7gDn3n1_D9wE6cUoDZBeNc1GFIDqD5CKsWck7FiTG4r014QLA5hi2PY4hg28M9OptOwNfpMn9IF4MUJkBkaaSFL5fKZ6-E7AHq-2OVifv3bl-mH6BhlrVjefhdfbuln2ny8Elf0D99ayfw</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Bellati, F</creator><creator>Pernice, M</creator><creator>Manci, N</creator><creator>Palaia, I</creator><creator>Tomao, F</creator><creator>Marchetti, C</creator><creator>Zullo, MA</creator><creator>Muzii, L</creator><creator>Angioli, R</creator><creator>Panici, P. Benedeth</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: the role of erythropoietic growth factors</title><author>Bellati, F ; Pernice, M ; Manci, N ; Palaia, I ; Tomao, F ; Marchetti, C ; Zullo, MA ; Muzii, L ; Angioli, R ; Panici, P. Benedeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-4b3bf1975dccf71d9b561e6ca60c19b04350350b3b81b01d6e92388e770cf9e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anemia - therapy</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion - statistics & numerical data</topic><topic>blood transfusions</topic><topic>Cervical cancer</topic><topic>Chemotherapy, Adjuvant</topic><topic>erythropoietic growth factors</topic><topic>Erythropoietin - therapeutic use</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>locally advanced cervical cancer</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>neo-adjuvant chemotherapy</topic><topic>Neoadjuvant Therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - blood</topic><topic>Uterine Cervical Neoplasms - complications</topic><topic>Uterine Cervical Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellati, F</creatorcontrib><creatorcontrib>Pernice, M</creatorcontrib><creatorcontrib>Manci, N</creatorcontrib><creatorcontrib>Palaia, I</creatorcontrib><creatorcontrib>Tomao, F</creatorcontrib><creatorcontrib>Marchetti, C</creatorcontrib><creatorcontrib>Zullo, MA</creatorcontrib><creatorcontrib>Muzii, L</creatorcontrib><creatorcontrib>Angioli, R</creatorcontrib><creatorcontrib>Panici, P. Benedeth</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellati, F</au><au>Pernice, M</au><au>Manci, N</au><au>Palaia, I</au><au>Tomao, F</au><au>Marchetti, C</au><au>Zullo, MA</au><au>Muzii, L</au><au>Angioli, R</au><au>Panici, P. Benedeth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: the role of erythropoietic growth factors</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>18</volume><issue>4</issue><spage>722</spage><epage>729</epage><pages>722-729</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Background: The objectives of the present study were to evaluate hemoglobin levels and consequent clinical behaviors related to anemia developed in patients affected by locally advanced cervical cancer treated with neo-adjuvant chemotherapy in the last decade and to evaluate the impact that the introduction of erythropoietic growth factors had in the clinical practice. Patients and methods: Blood chemistries, prospectively recorded from 98 cervical cancer patients, treated with neo-adjuvant chemotherapy and, if necessary, erythropoietic growth factors, were compared with matched historical controls before the introduction of growth factors in clinical practice. Results: Hemoglobin level in the study group did not differ significantly during chemotherapy. At the third cycle of chemotherapy and at the end of chemotherapy, hemoglobin level was significantly higher in the study group compared with the control group. Transfusion rates in the study group were significantly lower. The analysis within the study group revealed that hemoglobin level in patients who suffer at diagnosis from anemia tends to increase whereas hemoglobin level in nonanemic patients tends to decrease. Conclusions: Erythropoietic growth factors increase hemoglobin level and reduce blood transfusions in cervical cancer patients undergoing neo-adjuvant chemotherapy followed by radical surgery. An appropriate autologous blood donation program can noticeably reduce homologous blood transfusions.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17307758</pmid><doi>10.1093/annonc/mdl491</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0923-7534 |
| ispartof | Annals of oncology, 2007-04, Vol.18 (4), p.722-729 |
| issn | 0923-7534 1569-8041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70320604 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Anemia - therapy Antineoplastic agents Biological and medical sciences Blood Transfusion - statistics & numerical data blood transfusions Cervical cancer Chemotherapy, Adjuvant erythropoietic growth factors Erythropoietin - therapeutic use Female Female genital diseases Gynecology. Andrology. Obstetrics Hemoglobins - analysis Humans locally advanced cervical cancer Medical sciences Middle Aged neo-adjuvant chemotherapy Neoadjuvant Therapy Pharmacology. Drug treatments Tumors Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - complications Uterine Cervical Neoplasms - therapy |
| title | Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: the role of erythropoietic growth factors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T17%3A30%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hemoglobin%20variation%20and%20blood%20transfusion%20rates%20in%20patients%20affected%20by%20locally%20advanced%20cervical%20cancer%20undergoing%20neo-adjuvant%20chemotherapy%20followed%20by%20radical%20surgery:%20the%20role%20of%20erythropoietic%20growth%20factors&rft.jtitle=Annals%20of%20oncology&rft.au=Bellati,%20F&rft.date=2007-04-01&rft.volume=18&rft.issue=4&rft.spage=722&rft.epage=729&rft.pages=722-729&rft.issn=0923-7534&rft.eissn=1569-8041&rft_id=info:doi/10.1093/annonc/mdl491&rft_dat=%3Cproquest_cross%3E1250424101%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=196640569&rft_id=info:pmid/17307758&rfr_iscdi=true |