Clostridium difficile colitis that fails conventional metronidazole therapy: response to nitazoxanide

Objectives Clostridium difficile-associated disease has increased in incidence and severity. Recommended treatments include metronidazole and vancomycin. Recent investigations, however, document the failure of metronidazole to cure a substantial proportion of patients with Clostridium difficile coli...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2007-04, Vol.59 (4), p.705-710
Hauptverfasser:	Musher, Daniel M., Logan, Nancy, Mehendiratta, Vaibhav, Melgarejo, Nicolas A., Garud, Sagar, Hamill, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use antibiotic-associated diarrhoea Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria Biological and medical sciences C. difficile Clostridium Clostridium difficile Diarrhea Drug resistance Enterocolitis, Pseudomembranous - drug therapy Enterocolitis, Pseudomembranous - microbiology Female Humans Hypotheses Inflammatory bowel disease Male Medical sciences Metronidazole - therapeutic use Middle Aged Pharmacology Pharmacology. Drug treatments Recurrence Thiazoles - therapeutic use Treatment Failure vancomycin
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