Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats

Pharmacokinetics, metabolism and excretion of two sequential inactive metabolites of the soft corticosteroid loteprednol etabonate (LE), Δ1‐cortienic acid etabonate (AE) and Δ1‐cortienic acid (A), have been investigated in rats. Pharmacokinetic studies (two‐compartment model, 10 mg kg−1 intravenous...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2008-03, Vol.60 (3), p.291-297
Hauptverfasser:	Wu, Whei-Mei, Huang, Fenglei, Lee, Yangsuk, Buchwald, Peter, Bodor, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - administration & dosage Androstadienes - pharmacokinetics Animals Anti-Allergic Agents - pharmacokinetics Area Under Curve Dose-Response Relationship, Drug Half-Life Injections, Intravenous Loteprednol Etabonate Male Metabolic Clearance Rate Rats Rats, Sprague-Dawley
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