A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice

Purpose To preoperatively and intraoperatively localize the sentinel lymph node (SLN), a single hybrid probe for MR and near infrared (NIR) optical imaging was synthesized and tested. Materials and Methods A macromolecular MR/NIR optical contrast agent was synthesized based on a ∼191 gadolinium‐labe...

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Veröffentlicht in:	Journal of magnetic resonance imaging 2007-04, Vol.25 (4), p.866-871
Hauptverfasser:	Koyama, Yoshinori, Talanov, Vladimir S., Bernardo, Marcelino, Hama, Yukihiro, Regino, Celeste A.S., Brechbiel, Martin W., Choyke, Peter L., Kobayashi, Hisataka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - pathology Contrast Media Dendrimers - administration & dosage hybrid probe Lymph Nodes - pathology Lymphatic Metastasis - diagnosis Lymphography - methods macromolecular contrast agent Magnetic Resonance Imaging - methods Mammary Glands, Animal Mice MRI nanotechnology near infrared optical imaging sentinel lymph node Sentinel Lymph Node Biopsy Spectroscopy, Near-Infrared
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