The Azaallylic Anion as a Synthon for Pd-Catalyzed Synthesis of Heterocycles: Domino Two- and Three-Component Synthesis of Indoles

The Azaallylic Anion as a Synthon for Pd-Catalyzed Synthesis of Heterocycles: Domino Two- and Three-Component Synthesis of Indoles

Piecing it all together with palladium: Two‐ and three‐component cascade processes that are promoted by a multifunctional Pd catalyst lead to indoles in a highly efficient manner (see scheme). The key step is the Pd‐catalyzed α‐arylation of imines with o‐dihalobenzene derivatives.

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Veröffentlicht in:Angewandte Chemie International Edition 2007-01, Vol.46 (9), p.1529-1532
Hauptverfasser: Barluenga, José, Jiménez-Aquino, Agustín, Valdés, Carlos, Aznar, Fernando
Format: Artikel
Sprache:eng
Schlagworte:
arylation
indoles
multicomponent reactions
palladium
synthetic methods
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Zusammenfassung:Piecing it all together with palladium: Two‐ and three‐component cascade processes that are promoted by a multifunctional Pd catalyst lead to indoles in a highly efficient manner (see scheme). The key step is the Pd‐catalyzed α‐arylation of imines with o‐dihalobenzene derivatives.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200604407