Activities of DL-α-Difluoromethylarginine and Polyamine Analogues against Cryptosporidium parvum Infection in a T-Cell Receptor Alpha-Deficient Mouse Model

The in vivo effectiveness of a series of conformationally restricted polyamine analogues alone and selected members in combination with DL-α-difluoromethylarginine against Cryptosporidium parvum infection in a T-cell receptor alpha-deficient mouse model was tested. Polyamine analogues were selected...

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2007-04, Vol.51 (4), p.1234-1239
Hauptverfasser:	Yarlett, N, Harp, J.A, Wannemuehler, M.J, Morada, M, Bellcastro, J, Upton, S.J, Marton, L.J, Frydman, B.J
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Antiprotozoal Agents Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Arginine Arginine - analogs & derivatives Arginine - pharmacology Arginine - therapeutic use Cryptosporidiosis - drug therapy Cryptosporidium parvum Cryptosporidium parvum - drug effects difluoromethylarginine disease control Experimental Therapeutics Genes, T-Cell Receptor alpha Genes, T-Cell Receptor alpha - genetics immunity Mice Mice, Knockout Models, Animal Polyamines Polyamines - metabolism Polyamines - pharmacology Polyamines - therapeutic use protozoal infections receptors T-cell receptor
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