Effect of Aging and Caloric Restriction on the Mitochondrial Proteome

The rat mitochondrial proteome was analyzed using two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), and proteins altered by age or caloric restriction (CR) were identified using mass spectrometry. Of 2061 mitochondrial proteins analyzed in the three tissues, a significant change with ag...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2007-03, Vol.62 (3), p.223-234
Hauptverfasser:	Chang, Jinsook, Cornell, John E., Van Remmen, Holly, Hakala, Kevin, Ward, Walter F., Richardson, Arlan
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - genetics Aging - physiology Amino acids Animals Apoptosis Caloric Restriction Cells Changes Chronic illnesses Electrophoresis, Gel, Two-Dimensional Female Gerontology Heart Liver Mass Spectrometry Mitochondria - genetics Mitochondria, Heart - genetics Mitochondria, Liver - genetics Mitochondria, Muscle - genetics Mitochondrial DNA Mitochondrial Proteins - genetics Mitochondrial Proteins - isolation & purification Muscle Proteins - genetics Proteins Proteome - genetics Proteome - isolation & purification Rats Rats, Inbred F344
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