Trends of antiretroviral drug resistance in treatment-naive patients with human immunodeficiency virus type 1 infection in Taiwan
Objectives To determine the prevalence and trends of antiretroviral drug resistance among HIV-1-infected Taiwanese patients who have been provided with free-of-charge antiretroviral therapy (ART) since 1990. Methods Blood samples collected from 786 HIV-1-infected patients from 1999 to 2006 were subj...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2008-03, Vol.61 (3), p.689-693 |
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| creator | Chang, Sui-Yuan Chen, Mao-Yuan Lee, Chun-Nan Sun, Hsin-Yun Ko, Wilson Chang, Shu-Fang Chang, Kei-Lung Hsieh, Szu-Min Sheng, Wang-Huei Liu, Wen-Chun Wu, Cheng-Hsin Kao, Chuan-Liang Hung, Chien-Ching Chang, Shan-Chwen |
| description | Objectives To determine the prevalence and trends of antiretroviral drug resistance among HIV-1-infected Taiwanese patients who have been provided with free-of-charge antiretroviral therapy (ART) since 1990. Methods Blood samples collected from 786 HIV-1-infected patients from 1999 to 2006 were subjected to genotypic resistance assay. Antiretroviral resistance mutations were identified in accordance with the antiretroviral resistance mutation list of the International AIDS Society-USA Consensus Guidelines. Trends of resistance were studied in patients enrolled in two periods: before (period 1, January 1999 to December 2003) and after (period 2, January 2004 to December 2006) the CRF07_BC outbreak among injection drug users (IDUs). Results The frequency of HIV-1 isolates harbouring one or more primary mutations associated with antiretroviral resistance to reverse transcriptase inhibitors or protease inhibitors increased significantly from 6.6% in period 1 to 12.7% in period 2 (P = 0.003). A significant increase in prevalence of antiretroviral drug resistance was observed among men who have sex with men and patients infected with HIV subtype B. In multivariate analysis, hepatitis C virus (HCV) exposure, which exhibited collinearity with injection drug use and infection with CRF07_BC, represented a lower risk for infection with resistant viruses. Conclusions Our findings suggest that the prevalence of antiretroviral resistance has increased in Taiwan over the past 8 years after the introduction of combination ART. IDUs who were HCV-seropositive and infected with CRF07_BC were at lower risk for infection with antiretroviral-resistant viruses. |
| doi_str_mv | 10.1093/jac/dkn002 |
| format | Article |
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Methods Blood samples collected from 786 HIV-1-infected patients from 1999 to 2006 were subjected to genotypic resistance assay. Antiretroviral resistance mutations were identified in accordance with the antiretroviral resistance mutation list of the International AIDS Society-USA Consensus Guidelines. Trends of resistance were studied in patients enrolled in two periods: before (period 1, January 1999 to December 2003) and after (period 2, January 2004 to December 2006) the CRF07_BC outbreak among injection drug users (IDUs). Results The frequency of HIV-1 isolates harbouring one or more primary mutations associated with antiretroviral resistance to reverse transcriptase inhibitors or protease inhibitors increased significantly from 6.6% in period 1 to 12.7% in period 2 (P = 0.003). A significant increase in prevalence of antiretroviral drug resistance was observed among men who have sex with men and patients infected with HIV subtype B. In multivariate analysis, hepatitis C virus (HCV) exposure, which exhibited collinearity with injection drug use and infection with CRF07_BC, represented a lower risk for infection with resistant viruses. Conclusions Our findings suggest that the prevalence of antiretroviral resistance has increased in Taiwan over the past 8 years after the introduction of combination ART. IDUs who were HCV-seropositive and infected with CRF07_BC were at lower risk for infection with antiretroviral-resistant viruses.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkn002</identifier><identifier>PMID: 18227088</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Anti-Retroviral Agents - pharmacology ; Anti-Retroviral Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral drugs ; antiretroviral therapy ; Asian people ; Biological and medical sciences ; Chemotherapy ; Drug resistance ; Drug Resistance, Viral - drug effects ; Drug Resistance, Viral - genetics ; Female ; Hepatitis C virus ; highly active antiretroviral therapy ; HIV ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; HIV Infections - genetics ; HIV-1 ; HIV-1 - drug effects ; HIV-1 - genetics ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Male ; Medical sciences ; non-nucleoside reverse transcriptase inhibitors ; nucleoside reverse transcriptase inhibitors ; Pharmacology. Drug treatments ; protease inhibitors ; Taiwan - epidemiology ; Trends ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Journal of antimicrobial chemotherapy, 2008-03, Vol.61 (3), p.689-693</ispartof><rights>The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2008</rights><rights>2008 INIST-CNRS</rights><rights>The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-49d8c821386ef35048a7d47d4390d11195359ad405574049f9ff4538f543966f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20162958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18227088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Sui-Yuan</creatorcontrib><creatorcontrib>Chen, Mao-Yuan</creatorcontrib><creatorcontrib>Lee, Chun-Nan</creatorcontrib><creatorcontrib>Sun, Hsin-Yun</creatorcontrib><creatorcontrib>Ko, Wilson</creatorcontrib><creatorcontrib>Chang, Shu-Fang</creatorcontrib><creatorcontrib>Chang, Kei-Lung</creatorcontrib><creatorcontrib>Hsieh, Szu-Min</creatorcontrib><creatorcontrib>Sheng, Wang-Huei</creatorcontrib><creatorcontrib>Liu, Wen-Chun</creatorcontrib><creatorcontrib>Wu, Cheng-Hsin</creatorcontrib><creatorcontrib>Kao, Chuan-Liang</creatorcontrib><creatorcontrib>Hung, Chien-Ching</creatorcontrib><creatorcontrib>Chang, Shan-Chwen</creatorcontrib><title>Trends of antiretroviral drug resistance in treatment-naive patients with human immunodeficiency virus type 1 infection in Taiwan</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Objectives To determine the prevalence and trends of antiretroviral drug resistance among HIV-1-infected Taiwanese patients who have been provided with free-of-charge antiretroviral therapy (ART) since 1990. Methods Blood samples collected from 786 HIV-1-infected patients from 1999 to 2006 were subjected to genotypic resistance assay. Antiretroviral resistance mutations were identified in accordance with the antiretroviral resistance mutation list of the International AIDS Society-USA Consensus Guidelines. Trends of resistance were studied in patients enrolled in two periods: before (period 1, January 1999 to December 2003) and after (period 2, January 2004 to December 2006) the CRF07_BC outbreak among injection drug users (IDUs). Results The frequency of HIV-1 isolates harbouring one or more primary mutations associated with antiretroviral resistance to reverse transcriptase inhibitors or protease inhibitors increased significantly from 6.6% in period 1 to 12.7% in period 2 (P = 0.003). A significant increase in prevalence of antiretroviral drug resistance was observed among men who have sex with men and patients infected with HIV subtype B. In multivariate analysis, hepatitis C virus (HCV) exposure, which exhibited collinearity with injection drug use and infection with CRF07_BC, represented a lower risk for infection with resistant viruses. Conclusions Our findings suggest that the prevalence of antiretroviral resistance has increased in Taiwan over the past 8 years after the introduction of combination ART. IDUs who were HCV-seropositive and infected with CRF07_BC were at lower risk for infection with antiretroviral-resistant viruses.</description><subject>Adult</subject><subject>Anti-Retroviral Agents - pharmacology</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretroviral drugs</subject><subject>antiretroviral therapy</subject><subject>Asian people</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Drug resistance</subject><subject>Drug Resistance, Viral - drug effects</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Female</subject><subject>Hepatitis C virus</subject><subject>highly active antiretroviral therapy</subject><subject>HIV</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - genetics</subject><subject>HIV-1</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>non-nucleoside reverse transcriptase inhibitors</subject><subject>nucleoside reverse transcriptase inhibitors</subject><subject>Pharmacology. Drug treatments</subject><subject>protease inhibitors</subject><subject>Taiwan - epidemiology</subject><subject>Trends</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U9rFDEYBvBBFLutXvwAEgR7EMa--Z852qJWKHhZRbyEmElstjOZaZJp3aPf3JRdqnhQCITw_njCy9M0zzC8xtDRk42xJ_1VBCAPmhVmAloCHX7YrIACbyXj9KA5zHkDAIIL9bg5wIoQCUqtmp_r5GKf0eSRiSUkV9J0E5IZUJ-W7yi5HHIx0ToUIirJmTK6WNpowo1DsymhvjK6DeUSXS6jiSiM4xKn3vlg68xuUU1bMirb2SFcQ7yzJUzxLm5twq2JT5pH3gzZPd3fR82nd2_XZ-ftxcf3H87eXLSWSVla1vXKKoKpEs5TDkwZ2bN6aAc9xrjjlHemZ8C5ZMA633lfN1eeVyGEp0fN8S53TtP14nLRY8jWDYOJblqylkAxoZj_FxLgRBAsK3zxF9xMS4p1CV3HQmAGqqJXO2TTlHNyXs8pjCZtNQZ9V5-u9eldfRU_3ycu30bX_6b7vip4uQcmWzP4VKsJ-d4RwIJ0_A83LfO_P2x3rrbsftxLk660kFRyff7lq1annxnDROlT-gtg477d</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Chang, Sui-Yuan</creator><creator>Chen, Mao-Yuan</creator><creator>Lee, Chun-Nan</creator><creator>Sun, Hsin-Yun</creator><creator>Ko, Wilson</creator><creator>Chang, Shu-Fang</creator><creator>Chang, Kei-Lung</creator><creator>Hsieh, Szu-Min</creator><creator>Sheng, Wang-Huei</creator><creator>Liu, Wen-Chun</creator><creator>Wu, Cheng-Hsin</creator><creator>Kao, Chuan-Liang</creator><creator>Hung, Chien-Ching</creator><creator>Chang, Shan-Chwen</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Trends of antiretroviral drug resistance in treatment-naive patients with human immunodeficiency virus type 1 infection in Taiwan</title><author>Chang, Sui-Yuan ; Chen, Mao-Yuan ; Lee, Chun-Nan ; Sun, Hsin-Yun ; Ko, Wilson ; Chang, Shu-Fang ; Chang, Kei-Lung ; Hsieh, Szu-Min ; Sheng, Wang-Huei ; Liu, Wen-Chun ; Wu, Cheng-Hsin ; Kao, Chuan-Liang ; Hung, Chien-Ching ; Chang, Shan-Chwen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-49d8c821386ef35048a7d47d4390d11195359ad405574049f9ff4538f543966f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Anti-Retroviral Agents - pharmacology</topic><topic>Anti-Retroviral Agents - therapeutic use</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiretroviral drugs</topic><topic>antiretroviral therapy</topic><topic>Asian people</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Drug resistance</topic><topic>Drug Resistance, Viral - drug effects</topic><topic>Drug Resistance, Viral - genetics</topic><topic>Female</topic><topic>Hepatitis C virus</topic><topic>highly active antiretroviral therapy</topic><topic>HIV</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - genetics</topic><topic>HIV-1</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>non-nucleoside reverse transcriptase inhibitors</topic><topic>nucleoside reverse transcriptase inhibitors</topic><topic>Pharmacology. Drug treatments</topic><topic>protease inhibitors</topic><topic>Taiwan - epidemiology</topic><topic>Trends</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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Methods Blood samples collected from 786 HIV-1-infected patients from 1999 to 2006 were subjected to genotypic resistance assay. Antiretroviral resistance mutations were identified in accordance with the antiretroviral resistance mutation list of the International AIDS Society-USA Consensus Guidelines. Trends of resistance were studied in patients enrolled in two periods: before (period 1, January 1999 to December 2003) and after (period 2, January 2004 to December 2006) the CRF07_BC outbreak among injection drug users (IDUs). Results The frequency of HIV-1 isolates harbouring one or more primary mutations associated with antiretroviral resistance to reverse transcriptase inhibitors or protease inhibitors increased significantly from 6.6% in period 1 to 12.7% in period 2 (P = 0.003). A significant increase in prevalence of antiretroviral drug resistance was observed among men who have sex with men and patients infected with HIV subtype B. In multivariate analysis, hepatitis C virus (HCV) exposure, which exhibited collinearity with injection drug use and infection with CRF07_BC, represented a lower risk for infection with resistant viruses. Conclusions Our findings suggest that the prevalence of antiretroviral resistance has increased in Taiwan over the past 8 years after the introduction of combination ART. IDUs who were HCV-seropositive and infected with CRF07_BC were at lower risk for infection with antiretroviral-resistant viruses.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>18227088</pmid><doi>10.1093/jac/dkn002</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anti-Retroviral Agents - pharmacology Anti-Retroviral Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs antiretroviral therapy Asian people Biological and medical sciences Chemotherapy Drug resistance Drug Resistance, Viral - drug effects Drug Resistance, Viral - genetics Female Hepatitis C virus highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - genetics HIV-1 HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences non-nucleoside reverse transcriptase inhibitors nucleoside reverse transcriptase inhibitors Pharmacology. Drug treatments protease inhibitors Taiwan - epidemiology Trends Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Trends of antiretroviral drug resistance in treatment-naive patients with human immunodeficiency virus type 1 infection in Taiwan |
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