Peltophorum dubium and soybean Kunitz-type trypsin inhibitors induce human Jurkat cell apoptosis

Plants constitute an important source of compounds which can induce apoptosis in a variety of cells. Previously, we reported the isolation of a trypsin inhibitor from Peltophorum dubium seeds (PDTI). This inhibitor, as well as soybean trypsin inhibitor (SBTI), both belonging to the Kunitz family, ha...

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Veröffentlicht in:	International immunopharmacology 2007-05, Vol.7 (5), p.625-636
Hauptverfasser:	Troncoso, María F., Biron, Verónica A., Longhi, Silvia A., Retegui, Lilia A., Wolfenstein-Todel, Carlota
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biological and medical sciences Caspase Caspase Inhibitors Caspases - metabolism Cell Line, Tumor Cell Survival - drug effects Cytochrome c Cytochromes c - metabolism Cytosol - drug effects Cytosol - enzymology DNA Fragmentation - drug effects Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Fabaceae - chemistry Fas-associated death domain (FADD) Fas-Associated Death Domain Protein - metabolism HeLa Cells Humans In Vitro Techniques Jurkat cell apoptosis Jurkat Cells Lymphocytes - drug effects Medical sciences Mitochondria - enzymology Peltophorum Peltophorum dubium trypsin inhibitor Pharmacology. Drug treatments Phytohemagglutinins - pharmacology Seeds - chemistry Signal Transduction - drug effects Soybean trypsin inhibitor Trypsin Inhibitor, Kunitz Soybean - pharmacology Trypsin Inhibitors - pharmacology
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