Metabolism of Leishmania : proven and predicted
The complete analysis of the genomes of three major trypanosomatid parasites has facilitated comparison of the metabolic capabilities of each, as predicted from gene sequences. Not surprisingly, there are differences but is it possible to correlate these with the lives of the parasites themselves an...
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| Veröffentlicht in: | Trends in parasitology 2007-04, Vol.23 (4), p.149-158 |
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| container_title | Trends in parasitology |
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| creator | Opperdoes, Fred R Coombs, Graham H |
| description | The complete analysis of the genomes of three major trypanosomatid parasites has facilitated comparison of the metabolic capabilities of each, as predicted from gene sequences. Not surprisingly, there are differences but is it possible to correlate these with the lives of the parasites themselves and make further predictions of the meaning and physiological importance of the apparently parasite-specific metabolism? In this article, we relate gene predictions with the results from experimental studies. We also speculate on the key metabolic adaptations of Leishmania and reasons why it differs from Trypanosoma brucei and Trypanosoma cruzi. |
| doi_str_mv | 10.1016/j.pt.2007.02.004 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1471-4922 |
| ispartof | Trends in parasitology, 2007-04, Vol.23 (4), p.149-158 |
| issn | 1471-4922 1471-5007 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adaptation, Biological Animals Biological and medical sciences Biosynthetic Pathways Energy Metabolism Gastroenterology and Hepatology Genes, Protozoan Genome, Protozoan Human protozoal diseases Infectious Disease Infectious diseases Leishmania Leishmania major - genetics Leishmania major - metabolism Leshmaniasis Medical sciences Parasitic diseases Protozoal diseases Trypanosoma - genetics Trypanosoma - metabolism Trypanosoma brucei Trypanosoma cruzi |
| title | Metabolism of Leishmania : proven and predicted |
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