Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion
The underlying mechanisms for earlier hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) genotype B when compared with genotype C are unknown. We aimed to determine whether there were any differences in the T helper (Th) responses during hepatitis flares in...
Gespeichert in:
| Veröffentlicht in: | Journal of viral hepatitis 2007-04, Vol.14 (4), p.269-275 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 275 |
|---|---|
| container_issue | 4 |
| container_start_page | 269 |
| container_title | Journal of viral hepatitis |
| container_volume | 14 |
| creator | Yuen, M.-F. Wong, D.K-.H Zheng, B.-J. Chan, C.C-.S. Yuen, J.C-.H. Wong, B.C-.Y. Lai, C.-L. |
| description | The underlying mechanisms for earlier hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) genotype B when compared with genotype C are unknown. We aimed to determine whether there were any differences in the T helper (Th) responses during hepatitis flares in HBeAg‐positive patients with genotypes B and C. Proliferative response measured by 3H‐thymidine uptake and Th responses measured by Enzyme‐Linked Immunosorbent Spot assays for interleukin (IL)‐2, interferon‐gamma (IFN‐γ), IL‐4, IL‐5 and IL‐10 were performed in 10 patients with genotype B and 10 with genotype C with hepatitis flares. HBV genotypes, core promoter, precore mutations, sequence of HBV core region and HBV DNA levels were determined. There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN‐γ producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL‐10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, |
| doi_str_mv | 10.1111/j.1365-2893.2006.00799.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70310413</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70310413</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4049-4be78bdd3ec2576512edee16ceddbe549974e6f232e31e024c9f0e094691a5d43</originalsourceid><addsrcrecordid>eNqNkUFz0zAQhTUMDC2Fv8DsiYGDjWRJdsRwaUPbUAocKHDUKPY6VXAkIzlt8qf6G5GbTHtFF-3s-97bwyMEGM1Zeu-XOeOlzIqJ4nlBaZlTWimVb56Qwwfh6TjLIqOSigPyIsYlpYwXkj0nB6ziE1YxdUjuPtm2xYCuRrAOruAaux4DBIy9dxEjNOtg3SLtezPYwUZoO5PUkX7cnQCCcYNdoIO3sxM8XrzLeh-TdoMwQuiGCLd2uIaE-GHb42gyroHpB7CrvrN1oryD1gdAE7ot3MdAxOBr724wxCS_JM9a00V8tf-PyM-z06vpLLv8fv55enyZ1YIKlYk5VpN503CsC1mVkhXYILKyxqaZoxRKVQLLtuAFcoa0ELVqKVIlSsWMbAQ_Im92uX3wf9cYB72yscauMw79OuqKckYF4wmc7MA6-BgDtroPdmXCVjOqx670Uo-V6LESPXal77vSm2R9vb-xnq-weTTuy0nAxx1wazvc_newvvg1S0OyZzu7jQNuHuwm_NFlxSupf38712f8opz9-Cr1F_4PcFa0hA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70310413</pqid></control><display><type>article</type><title>Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yuen, M.-F. ; Wong, D.K-.H ; Zheng, B.-J. ; Chan, C.C-.S. ; Yuen, J.C-.H. ; Wong, B.C-.Y. ; Lai, C.-L.</creator><creatorcontrib>Yuen, M.-F. ; Wong, D.K-.H ; Zheng, B.-J. ; Chan, C.C-.S. ; Yuen, J.C-.H. ; Wong, B.C-.Y. ; Lai, C.-L.</creatorcontrib><description>The underlying mechanisms for earlier hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) genotype B when compared with genotype C are unknown. We aimed to determine whether there were any differences in the T helper (Th) responses during hepatitis flares in HBeAg‐positive patients with genotypes B and C. Proliferative response measured by 3H‐thymidine uptake and Th responses measured by Enzyme‐Linked Immunosorbent Spot assays for interleukin (IL)‐2, interferon‐gamma (IFN‐γ), IL‐4, IL‐5 and IL‐10 were performed in 10 patients with genotype B and 10 with genotype C with hepatitis flares. HBV genotypes, core promoter, precore mutations, sequence of HBV core region and HBV DNA levels were determined. There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN‐γ producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL‐10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively). There was a trend (P = 0.058) that patients with genotype B had a higher cumulative rate of HBeAg seroconversion. Patients with precore mutants also had a significantly higher number of IFN‐γ producing cells (with HBcAg stimulation) and lower number of IL‐10 producing cells (with HBeAg stimulation) compared to patients without precore mutant (P = 0.038, =0.016 respectively). HBV genotype B induces a greater Th1 and lesser Th2 response than genotype C. This provides immunologic evidence for the higher chance of HBeAg seroconversion in patients with genotype B.</description><identifier>ISSN: 1352-0504</identifier><identifier>EISSN: 1365-2893</identifier><identifier>DOI: 10.1111/j.1365-2893.2006.00799.x</identifier><identifier>PMID: 17381719</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Female ; Genetic Predisposition to Disease ; Genotype ; Hepatitis B Core Antigens - genetics ; Hepatitis B Core Antigens - immunology ; hepatitis B e antigen seroconversion ; Hepatitis B e Antigens - biosynthesis ; Hepatitis B e Antigens - genetics ; Hepatitis B e Antigens - immunology ; hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B virus - immunology ; Hepatitis B, Chronic - genetics ; Hepatitis B, Chronic - immunology ; Hepatitis B, Chronic - virology ; Humans ; immune response ; Interferon-gamma - biosynthesis ; Interferon-gamma - immunology ; Interleukin-10 - immunology ; Interleukin-2 - immunology ; Interleukin-4 - immunology ; Interleukin-5 - immunology ; Lymphocyte Activation ; Male ; Middle Aged ; Mutation ; Promoter Regions, Genetic ; T helper response ; Th1 Cells - immunology ; Th2 Cells - immunology</subject><ispartof>Journal of viral hepatitis, 2007-04, Vol.14 (4), p.269-275</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4049-4be78bdd3ec2576512edee16ceddbe549974e6f232e31e024c9f0e094691a5d43</citedby><cites>FETCH-LOGICAL-c4049-4be78bdd3ec2576512edee16ceddbe549974e6f232e31e024c9f0e094691a5d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2893.2006.00799.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2893.2006.00799.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17381719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuen, M.-F.</creatorcontrib><creatorcontrib>Wong, D.K-.H</creatorcontrib><creatorcontrib>Zheng, B.-J.</creatorcontrib><creatorcontrib>Chan, C.C-.S.</creatorcontrib><creatorcontrib>Yuen, J.C-.H.</creatorcontrib><creatorcontrib>Wong, B.C-.Y.</creatorcontrib><creatorcontrib>Lai, C.-L.</creatorcontrib><title>Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion</title><title>Journal of viral hepatitis</title><addtitle>J Viral Hepat</addtitle><description>The underlying mechanisms for earlier hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) genotype B when compared with genotype C are unknown. We aimed to determine whether there were any differences in the T helper (Th) responses during hepatitis flares in HBeAg‐positive patients with genotypes B and C. Proliferative response measured by 3H‐thymidine uptake and Th responses measured by Enzyme‐Linked Immunosorbent Spot assays for interleukin (IL)‐2, interferon‐gamma (IFN‐γ), IL‐4, IL‐5 and IL‐10 were performed in 10 patients with genotype B and 10 with genotype C with hepatitis flares. HBV genotypes, core promoter, precore mutations, sequence of HBV core region and HBV DNA levels were determined. There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN‐γ producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL‐10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively). There was a trend (P = 0.058) that patients with genotype B had a higher cumulative rate of HBeAg seroconversion. Patients with precore mutants also had a significantly higher number of IFN‐γ producing cells (with HBcAg stimulation) and lower number of IL‐10 producing cells (with HBeAg stimulation) compared to patients without precore mutant (P = 0.038, =0.016 respectively). HBV genotype B induces a greater Th1 and lesser Th2 response than genotype C. This provides immunologic evidence for the higher chance of HBeAg seroconversion in patients with genotype B.</description><subject>Adult</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hepatitis B Core Antigens - genetics</subject><subject>Hepatitis B Core Antigens - immunology</subject><subject>hepatitis B e antigen seroconversion</subject><subject>Hepatitis B e Antigens - biosynthesis</subject><subject>Hepatitis B e Antigens - genetics</subject><subject>Hepatitis B e Antigens - immunology</subject><subject>hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B, Chronic - genetics</subject><subject>Hepatitis B, Chronic - immunology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Humans</subject><subject>immune response</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - immunology</subject><subject>Interleukin-10 - immunology</subject><subject>Interleukin-2 - immunology</subject><subject>Interleukin-4 - immunology</subject><subject>Interleukin-5 - immunology</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Promoter Regions, Genetic</subject><subject>T helper response</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><issn>1352-0504</issn><issn>1365-2893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFz0zAQhTUMDC2Fv8DsiYGDjWRJdsRwaUPbUAocKHDUKPY6VXAkIzlt8qf6G5GbTHtFF-3s-97bwyMEGM1Zeu-XOeOlzIqJ4nlBaZlTWimVb56Qwwfh6TjLIqOSigPyIsYlpYwXkj0nB6ziE1YxdUjuPtm2xYCuRrAOruAaux4DBIy9dxEjNOtg3SLtezPYwUZoO5PUkX7cnQCCcYNdoIO3sxM8XrzLeh-TdoMwQuiGCLd2uIaE-GHb42gyroHpB7CrvrN1oryD1gdAE7ot3MdAxOBr724wxCS_JM9a00V8tf-PyM-z06vpLLv8fv55enyZ1YIKlYk5VpN503CsC1mVkhXYILKyxqaZoxRKVQLLtuAFcoa0ELVqKVIlSsWMbAQ_Im92uX3wf9cYB72yscauMw79OuqKckYF4wmc7MA6-BgDtroPdmXCVjOqx670Uo-V6LESPXal77vSm2R9vb-xnq-weTTuy0nAxx1wazvc_newvvg1S0OyZzu7jQNuHuwm_NFlxSupf38712f8opz9-Cr1F_4PcFa0hA</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Yuen, M.-F.</creator><creator>Wong, D.K-.H</creator><creator>Zheng, B.-J.</creator><creator>Chan, C.C-.S.</creator><creator>Yuen, J.C-.H.</creator><creator>Wong, B.C-.Y.</creator><creator>Lai, C.-L.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion</title><author>Yuen, M.-F. ; Wong, D.K-.H ; Zheng, B.-J. ; Chan, C.C-.S. ; Yuen, J.C-.H. ; Wong, B.C-.Y. ; Lai, C.-L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4049-4be78bdd3ec2576512edee16ceddbe549974e6f232e31e024c9f0e094691a5d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hepatitis B Core Antigens - genetics</topic><topic>Hepatitis B Core Antigens - immunology</topic><topic>hepatitis B e antigen seroconversion</topic><topic>Hepatitis B e Antigens - biosynthesis</topic><topic>Hepatitis B e Antigens - genetics</topic><topic>Hepatitis B e Antigens - immunology</topic><topic>hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B, Chronic - genetics</topic><topic>Hepatitis B, Chronic - immunology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Humans</topic><topic>immune response</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - immunology</topic><topic>Interleukin-10 - immunology</topic><topic>Interleukin-2 - immunology</topic><topic>Interleukin-4 - immunology</topic><topic>Interleukin-5 - immunology</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Promoter Regions, Genetic</topic><topic>T helper response</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuen, M.-F.</creatorcontrib><creatorcontrib>Wong, D.K-.H</creatorcontrib><creatorcontrib>Zheng, B.-J.</creatorcontrib><creatorcontrib>Chan, C.C-.S.</creatorcontrib><creatorcontrib>Yuen, J.C-.H.</creatorcontrib><creatorcontrib>Wong, B.C-.Y.</creatorcontrib><creatorcontrib>Lai, C.-L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of viral hepatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuen, M.-F.</au><au>Wong, D.K-.H</au><au>Zheng, B.-J.</au><au>Chan, C.C-.S.</au><au>Yuen, J.C-.H.</au><au>Wong, B.C-.Y.</au><au>Lai, C.-L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion</atitle><jtitle>Journal of viral hepatitis</jtitle><addtitle>J Viral Hepat</addtitle><date>2007-04</date><risdate>2007</risdate><volume>14</volume><issue>4</issue><spage>269</spage><epage>275</epage><pages>269-275</pages><issn>1352-0504</issn><eissn>1365-2893</eissn><abstract>The underlying mechanisms for earlier hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) genotype B when compared with genotype C are unknown. We aimed to determine whether there were any differences in the T helper (Th) responses during hepatitis flares in HBeAg‐positive patients with genotypes B and C. Proliferative response measured by 3H‐thymidine uptake and Th responses measured by Enzyme‐Linked Immunosorbent Spot assays for interleukin (IL)‐2, interferon‐gamma (IFN‐γ), IL‐4, IL‐5 and IL‐10 were performed in 10 patients with genotype B and 10 with genotype C with hepatitis flares. HBV genotypes, core promoter, precore mutations, sequence of HBV core region and HBV DNA levels were determined. There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN‐γ producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL‐10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively). There was a trend (P = 0.058) that patients with genotype B had a higher cumulative rate of HBeAg seroconversion. Patients with precore mutants also had a significantly higher number of IFN‐γ producing cells (with HBcAg stimulation) and lower number of IL‐10 producing cells (with HBeAg stimulation) compared to patients without precore mutant (P = 0.038, =0.016 respectively). HBV genotype B induces a greater Th1 and lesser Th2 response than genotype C. This provides immunologic evidence for the higher chance of HBeAg seroconversion in patients with genotype B.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17381719</pmid><doi>10.1111/j.1365-2893.2006.00799.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1352-0504 |
| ispartof | Journal of viral hepatitis, 2007-04, Vol.14 (4), p.269-275 |
| issn | 1352-0504 1365-2893 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70310413 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Female Genetic Predisposition to Disease Genotype Hepatitis B Core Antigens - genetics Hepatitis B Core Antigens - immunology hepatitis B e antigen seroconversion Hepatitis B e Antigens - biosynthesis Hepatitis B e Antigens - genetics Hepatitis B e Antigens - immunology hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B, Chronic - genetics Hepatitis B, Chronic - immunology Hepatitis B, Chronic - virology Humans immune response Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin-10 - immunology Interleukin-2 - immunology Interleukin-4 - immunology Interleukin-5 - immunology Lymphocyte Activation Male Middle Aged Mutation Promoter Regions, Genetic T helper response Th1 Cells - immunology Th2 Cells - immunology |
| title | Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)-positive patients with genotypes B and C: implication for early HBeAg seroconversion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A39%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Difference%20in%20T%20helper%20responses%20during%20hepatitis%20flares%20in%20hepatitis%20B%20e%20antigen%20(HBeAg)-positive%20patients%20with%20genotypes%20B%20and%20C:%20implication%20for%20early%20HBeAg%20seroconversion&rft.jtitle=Journal%20of%20viral%20hepatitis&rft.au=Yuen,%20M.-F.&rft.date=2007-04&rft.volume=14&rft.issue=4&rft.spage=269&rft.epage=275&rft.pages=269-275&rft.issn=1352-0504&rft.eissn=1365-2893&rft_id=info:doi/10.1111/j.1365-2893.2006.00799.x&rft_dat=%3Cproquest_cross%3E70310413%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70310413&rft_id=info:pmid/17381719&rfr_iscdi=true |