Regulation of dendritic cell differentiation and subset distribution by the zinc finger protein CTCF

Abstract The molecular mechanisms that regulate DC differentiation and subset distribution are largely unknown. In this study we report the identification of the C2 H2 zinc finger transcription factors (TF) CTCF as a regulator of DC differentiation. CTCF was expressed in human and murine DC and its...

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Veröffentlicht in:	Immunology Letters 2007-04, Vol.109 (2), p.165-174
Hauptverfasser:	Koesters, Christina, Unger, Bernd, Bilic, Ivan, Schmidt, Uwe, Bluml, Stefan, Lichtenberger, Beate, Schreiber, Martin, Stockl, Johannes, Ellmeier, Wilfried
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Bone Marrow Cells - cytology Bone Marrow Cells - immunology CCCTC-Binding Factor Cell differentiation Cell Differentiation - immunology Cell Growth Processes - immunology Cell Survival - immunology Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - immunology Down-Regulation Humans Mice Mice, Inbred BALB C Mice, Inbred C57BL Repressor Proteins - biosynthesis Repressor Proteins - immunology Toll-Like Receptors - immunology Toll-Like Receptors - metabolism Transcription factors Transcription Factors - genetics Zinc Fingers
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