Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity

: Background: The susceptibility of porcine endothelial cells (pEC) to human natural killer (NK) cells is related to the failure of human major histocompatibility complex (MHC)‐specific killer inhibitory receptors to recognize porcine MHC class I molecules. The aims of this study were (i) to asses...

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Veröffentlicht in:	Xenotransplantation (Københaven) 2007-03, Vol.14 (2), p.126-134
Hauptverfasser:	Lilienfeld, Benjamin G., Crew, Mark D., Forte, Pietro, Baumann, Bettina C., Seebach, Jörg D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Heterophile - immunology CD94/NKG2A Cell Adhesion - physiology Cell Communication - immunology Cell Communication - physiology Cell Line cytotoxicity Cytotoxicity, Immunologic - immunology Cytotoxicity, Immunologic - physiology Endothelium, Vascular - cytology Endothelium, Vascular - immunology Endothelium, Vascular - physiology Gene Expression Regulation - physiology Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - physiology HLA Antigens - genetics HLA Antigens - physiology HLA-E HLA-E Antigens Humans Killer Cells, Natural - immunology Killer Cells, Natural - physiology natural killer cells NK Cell Lectin-Like Receptor Subfamily D - immunology Swine Transfection Transgenes - genetics Transgenes - physiology Transplantation, Heterologous - methods
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