New insight into the recognition of branched DNA structure by junction-resolving enzymes
Junction-resolving enzymes are nucleases that exhibit structural selectivity for the four-way (Holliday) junction in DNA. In general, these enzymes both recognize and distort the structure of the junction. New insight into the molecular recognition processes has been provided by two recent co-crysta...
Gespeichert in:
| Veröffentlicht in: | Current opinion in structural biology 2008-02, Vol.18 (1), p.86-95 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 95 |
|---|---|
| container_issue | 1 |
| container_start_page | 86 |
| container_title | Current opinion in structural biology |
| container_volume | 18 |
| creator | Déclais, Anne-Cécile Lilley, David MJ |
| description | Junction-resolving enzymes are nucleases that exhibit structural selectivity for the four-way (Holliday) junction in DNA. In general, these enzymes both recognize and distort the structure of the junction. New insight into the molecular recognition processes has been provided by two recent co-crystal structures of resolving enzymes bound to four-way DNA junctions in highly contrasting ways. T4 endonuclease VII binds the junction in an open conformation to an approximately flat binding surface whereas T7 endonuclease I envelops the junction, which retains a much more three-dimensional structure. Both proteins make contacts with the DNA backbone over an extensive area in order to generate structural specificity. The comparison highlights the versatility of Holliday junction resolution, and extracts some general principles of recognition. |
| doi_str_mv | 10.1016/j.sbi.2007.11.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70309399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0959440X07001765</els_id><sourcerecordid>70309399</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-da7d71daa47a390575e420cea481db560310257de400ca4734502be0586057603</originalsourceid><addsrcrecordid>eNqFkE1vEzEURS1UREPhB7BBXnU3w_PYMx6LVdXyJVVlA1J2lsd-SRwldrE9rcKvx1EisYPVXdxz7-IQ8o5By4ANH7ZtnnzbAciWsRaAvSALNkrVAOfLC7IA1atGCFhektc5bwFgYGJ8RS7ZyAboZL8gywd8pj5kv96UmiXSskGa0MZ18MXHQOOKTskEu0FH7x5uaC5ptmVOSKcD3c7BHqkmYY67Jx_WFMPvwx7zG_JyZXYZ357zivz8_OnH7dfm_vuXb7c3943lY1caZ6STzBkjpOEKetmj6MCiESNzUz8AZ9D10qEAsBXiooduQujHocK1viLXp9_HFH_NmIve-2xxtzMB45y1BA6KK_VfkCk-SCV4BdkJtCnmnHClH5Pfm3TQDPTRu97q6l0fvWvGdPVeN-_P5_O0R_d3cRZdgY8nAKuLJ49JZ-sxWHS-yi7aRf-P-z9h0pLK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19367943</pqid></control><display><type>article</type><title>New insight into the recognition of branched DNA structure by junction-resolving enzymes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Déclais, Anne-Cécile ; Lilley, David MJ</creator><creatorcontrib>Déclais, Anne-Cécile ; Lilley, David MJ</creatorcontrib><description>Junction-resolving enzymes are nucleases that exhibit structural selectivity for the four-way (Holliday) junction in DNA. In general, these enzymes both recognize and distort the structure of the junction. New insight into the molecular recognition processes has been provided by two recent co-crystal structures of resolving enzymes bound to four-way DNA junctions in highly contrasting ways. T4 endonuclease VII binds the junction in an open conformation to an approximately flat binding surface whereas T7 endonuclease I envelops the junction, which retains a much more three-dimensional structure. Both proteins make contacts with the DNA backbone over an extensive area in order to generate structural specificity. The comparison highlights the versatility of Holliday junction resolution, and extracts some general principles of recognition.</description><identifier>ISSN: 0959-440X</identifier><identifier>EISSN: 1879-033X</identifier><identifier>DOI: 10.1016/j.sbi.2007.11.001</identifier><identifier>PMID: 18160275</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Binding Sites ; Deoxyribonuclease I - chemistry ; Deoxyribonuclease I - metabolism ; DNA Restriction Enzymes - chemistry ; DNA Restriction Enzymes - metabolism ; DNA, Cruciform - chemistry ; DNA, Cruciform - metabolism ; Endodeoxyribonucleases - chemistry ; Endodeoxyribonucleases - metabolism ; Holliday Junction Resolvases - chemistry ; Holliday Junction Resolvases - metabolism ; Humans ; Models, Molecular ; Nucleic Acid Conformation ; Protein Conformation</subject><ispartof>Current opinion in structural biology, 2008-02, Vol.18 (1), p.86-95</ispartof><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-da7d71daa47a390575e420cea481db560310257de400ca4734502be0586057603</citedby><cites>FETCH-LOGICAL-c382t-da7d71daa47a390575e420cea481db560310257de400ca4734502be0586057603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0959440X07001765$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18160275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Déclais, Anne-Cécile</creatorcontrib><creatorcontrib>Lilley, David MJ</creatorcontrib><title>New insight into the recognition of branched DNA structure by junction-resolving enzymes</title><title>Current opinion in structural biology</title><addtitle>Curr Opin Struct Biol</addtitle><description>Junction-resolving enzymes are nucleases that exhibit structural selectivity for the four-way (Holliday) junction in DNA. In general, these enzymes both recognize and distort the structure of the junction. New insight into the molecular recognition processes has been provided by two recent co-crystal structures of resolving enzymes bound to four-way DNA junctions in highly contrasting ways. T4 endonuclease VII binds the junction in an open conformation to an approximately flat binding surface whereas T7 endonuclease I envelops the junction, which retains a much more three-dimensional structure. Both proteins make contacts with the DNA backbone over an extensive area in order to generate structural specificity. The comparison highlights the versatility of Holliday junction resolution, and extracts some general principles of recognition.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Deoxyribonuclease I - chemistry</subject><subject>Deoxyribonuclease I - metabolism</subject><subject>DNA Restriction Enzymes - chemistry</subject><subject>DNA Restriction Enzymes - metabolism</subject><subject>DNA, Cruciform - chemistry</subject><subject>DNA, Cruciform - metabolism</subject><subject>Endodeoxyribonucleases - chemistry</subject><subject>Endodeoxyribonucleases - metabolism</subject><subject>Holliday Junction Resolvases - chemistry</subject><subject>Holliday Junction Resolvases - metabolism</subject><subject>Humans</subject><subject>Models, Molecular</subject><subject>Nucleic Acid Conformation</subject><subject>Protein Conformation</subject><issn>0959-440X</issn><issn>1879-033X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vEzEURS1UREPhB7BBXnU3w_PYMx6LVdXyJVVlA1J2lsd-SRwldrE9rcKvx1EisYPVXdxz7-IQ8o5By4ANH7ZtnnzbAciWsRaAvSALNkrVAOfLC7IA1atGCFhektc5bwFgYGJ8RS7ZyAboZL8gywd8pj5kv96UmiXSskGa0MZ18MXHQOOKTskEu0FH7x5uaC5ptmVOSKcD3c7BHqkmYY67Jx_WFMPvwx7zG_JyZXYZ357zivz8_OnH7dfm_vuXb7c3943lY1caZ6STzBkjpOEKetmj6MCiESNzUz8AZ9D10qEAsBXiooduQujHocK1viLXp9_HFH_NmIve-2xxtzMB45y1BA6KK_VfkCk-SCV4BdkJtCnmnHClH5Pfm3TQDPTRu97q6l0fvWvGdPVeN-_P5_O0R_d3cRZdgY8nAKuLJ49JZ-sxWHS-yi7aRf-P-z9h0pLK</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Déclais, Anne-Cécile</creator><creator>Lilley, David MJ</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>New insight into the recognition of branched DNA structure by junction-resolving enzymes</title><author>Déclais, Anne-Cécile ; Lilley, David MJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-da7d71daa47a390575e420cea481db560310257de400ca4734502be0586057603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Deoxyribonuclease I - chemistry</topic><topic>Deoxyribonuclease I - metabolism</topic><topic>DNA Restriction Enzymes - chemistry</topic><topic>DNA Restriction Enzymes - metabolism</topic><topic>DNA, Cruciform - chemistry</topic><topic>DNA, Cruciform - metabolism</topic><topic>Endodeoxyribonucleases - chemistry</topic><topic>Endodeoxyribonucleases - metabolism</topic><topic>Holliday Junction Resolvases - chemistry</topic><topic>Holliday Junction Resolvases - metabolism</topic><topic>Humans</topic><topic>Models, Molecular</topic><topic>Nucleic Acid Conformation</topic><topic>Protein Conformation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Déclais, Anne-Cécile</creatorcontrib><creatorcontrib>Lilley, David MJ</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in structural biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Déclais, Anne-Cécile</au><au>Lilley, David MJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New insight into the recognition of branched DNA structure by junction-resolving enzymes</atitle><jtitle>Current opinion in structural biology</jtitle><addtitle>Curr Opin Struct Biol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>18</volume><issue>1</issue><spage>86</spage><epage>95</epage><pages>86-95</pages><issn>0959-440X</issn><eissn>1879-033X</eissn><abstract>Junction-resolving enzymes are nucleases that exhibit structural selectivity for the four-way (Holliday) junction in DNA. In general, these enzymes both recognize and distort the structure of the junction. New insight into the molecular recognition processes has been provided by two recent co-crystal structures of resolving enzymes bound to four-way DNA junctions in highly contrasting ways. T4 endonuclease VII binds the junction in an open conformation to an approximately flat binding surface whereas T7 endonuclease I envelops the junction, which retains a much more three-dimensional structure. Both proteins make contacts with the DNA backbone over an extensive area in order to generate structural specificity. The comparison highlights the versatility of Holliday junction resolution, and extracts some general principles of recognition.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18160275</pmid><doi>10.1016/j.sbi.2007.11.001</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-440X |
| ispartof | Current opinion in structural biology, 2008-02, Vol.18 (1), p.86-95 |
| issn | 0959-440X 1879-033X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70309399 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Binding Sites Deoxyribonuclease I - chemistry Deoxyribonuclease I - metabolism DNA Restriction Enzymes - chemistry DNA Restriction Enzymes - metabolism DNA, Cruciform - chemistry DNA, Cruciform - metabolism Endodeoxyribonucleases - chemistry Endodeoxyribonucleases - metabolism Holliday Junction Resolvases - chemistry Holliday Junction Resolvases - metabolism Humans Models, Molecular Nucleic Acid Conformation Protein Conformation |
| title | New insight into the recognition of branched DNA structure by junction-resolving enzymes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T21%3A55%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20insight%20into%20the%20recognition%20of%20branched%20DNA%20structure%20by%20junction-resolving%20enzymes&rft.jtitle=Current%20opinion%20in%20structural%20biology&rft.au=D%C3%A9clais,%20Anne-C%C3%A9cile&rft.date=2008-02-01&rft.volume=18&rft.issue=1&rft.spage=86&rft.epage=95&rft.pages=86-95&rft.issn=0959-440X&rft.eissn=1879-033X&rft_id=info:doi/10.1016/j.sbi.2007.11.001&rft_dat=%3Cproquest_cross%3E70309399%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19367943&rft_id=info:pmid/18160275&rft_els_id=S0959440X07001765&rfr_iscdi=true |