Increased arousal in a patient with anoxic brain injury after administration of zolpidem
A 35-yr-old man sustained an anoxic brain injury resulting from cardiac arrest, with subsequent extreme lethargy and lack of response to stimuli. The patient's lethargy was unresponsive to trials of several medications in attempts to increase arousal. Administration of twice-daily zolpidem 8 mo...
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| Veröffentlicht in: | American journal of physical medicine & rehabilitation 2008-03, Vol.87 (3), p.229-231 |
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| container_title | American journal of physical medicine & rehabilitation |
| container_volume | 87 |
| creator | Cohen, Sara I Duong, Thao T |
| description | A 35-yr-old man sustained an anoxic brain injury resulting from cardiac arrest, with subsequent extreme lethargy and lack of response to stimuli. The patient's lethargy was unresponsive to trials of several medications in attempts to increase arousal. Administration of twice-daily zolpidem 8 mos after injury resulted in a dramatic increase in the level of alertness, including improved speech and gait. When the patient was not able to receive zolpidem for a brief period, the patient's lethargy returned, and he became bedbound until the medication was resumed. |
| doi_str_mv | 10.1097/PHM.0b013e318161971b |
| format | Article |
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The patient's lethargy was unresponsive to trials of several medications in attempts to increase arousal. Administration of twice-daily zolpidem 8 mos after injury resulted in a dramatic increase in the level of alertness, including improved speech and gait. When the patient was not able to receive zolpidem for a brief period, the patient's lethargy returned, and he became bedbound until the medication was resumed.</description><subject>Adult</subject><subject>Arousal - drug effects</subject><subject>GABA Agonists - pharmacology</subject><subject>GABA Agonists - therapeutic use</subject><subject>Humans</subject><subject>Hypoxia, Brain - complications</subject><subject>Male</subject><subject>Persistent Vegetative State - drug therapy</subject><subject>Persistent Vegetative State - etiology</subject><subject>Persistent Vegetative State - rehabilitation</subject><subject>Pyridines - pharmacology</subject><subject>Pyridines - therapeutic use</subject><issn>0894-9115</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1LAzEURbNQbK3-A5Gs3E19mUyayVKK2oKiCwV3w8vkDabMR01m0PrrHWlBcPUW99wL7zB2IWAuwOjr59XjHCwISVLkYiGMFvaITSE3WWKEUBN2GuMGAJSR-oRNRkhnuYIpe1u3ZSCM5DiGbohYc99y5FvsPbU9__T9O8e2-_IltwHHzLebIew4Vj0Fjq7xrY99GPGu5V3Fv7t66x01Z-y4wjrS-eHO2Ovd7ctylTw83a-XNw9JKUH1SSoNammMUkALl1WlTilVSJUTlbGpIkfWpUYalwOSzkEDOrsQVqS5EVbKGbva725D9zFQ7IvGx5LqGlsa_yk0SDCpUSOY7cEydDEGqopt8A2GXSGg-LVYjBaL_xbH2uVhf7ANub_SQaH8AWZhcbw</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Cohen, Sara I</creator><creator>Duong, Thao T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>Increased arousal in a patient with anoxic brain injury after administration of zolpidem</title><author>Cohen, Sara I ; Duong, Thao T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-239a7399550e6d4fc72e25aefd1f9b25edebd2939d80ae78070adb61b12891b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Arousal - drug effects</topic><topic>GABA Agonists - pharmacology</topic><topic>GABA Agonists - therapeutic use</topic><topic>Humans</topic><topic>Hypoxia, Brain - complications</topic><topic>Male</topic><topic>Persistent Vegetative State - drug therapy</topic><topic>Persistent Vegetative State - etiology</topic><topic>Persistent Vegetative State - rehabilitation</topic><topic>Pyridines - pharmacology</topic><topic>Pyridines - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, Sara I</creatorcontrib><creatorcontrib>Duong, Thao T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physical medicine & rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Sara I</au><au>Duong, Thao T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased arousal in a patient with anoxic brain injury after administration of zolpidem</atitle><jtitle>American journal of physical medicine & rehabilitation</jtitle><addtitle>Am J Phys Med Rehabil</addtitle><date>2008-03</date><risdate>2008</risdate><volume>87</volume><issue>3</issue><spage>229</spage><epage>231</epage><pages>229-231</pages><issn>0894-9115</issn><abstract>A 35-yr-old man sustained an anoxic brain injury resulting from cardiac arrest, with subsequent extreme lethargy and lack of response to stimuli. 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| fulltext | fulltext |
| identifier | ISSN: 0894-9115 |
| ispartof | American journal of physical medicine & rehabilitation, 2008-03, Vol.87 (3), p.229-231 |
| issn | 0894-9115 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70309295 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Arousal - drug effects GABA Agonists - pharmacology GABA Agonists - therapeutic use Humans Hypoxia, Brain - complications Male Persistent Vegetative State - drug therapy Persistent Vegetative State - etiology Persistent Vegetative State - rehabilitation Pyridines - pharmacology Pyridines - therapeutic use |
| title | Increased arousal in a patient with anoxic brain injury after administration of zolpidem |
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