SARM: a novel Toll-like receptor adaptor, is functionally conserved from arthropod to human

Sterile-alpha and Armadillo motif containing protein (SARM) was recently identified as the fifth member of the Toll-like receptor (TLR) adaptor family. Whilst the Caenorhabditis elegans SARM homologue, TIR-1, is crucial for efficient immune responses against bacterial infections, human SARM was demo...

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Veröffentlicht in:	Molecular immunology 2008-03, Vol.45 (6), p.1732-1742
Hauptverfasser:	Belinda, Loh Wei-Ching, Wei, Wang Xiao, Hanh, Bui Thi Hong, Lei, Luan Xiao, Bow, Ho, Ling, Ding Jeak
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Armadillo Domain Proteins - genetics Armadillo Domain Proteins - physiology Arthropoda Caenorhabditis elegans Carcinoscorpius rotundicauda Conserved Sequence Cytoskeletal Proteins - genetics Cytoskeletal Proteins - physiology Decapoda Horseshoe Crabs - metabolism Horseshoe Crabs - microbiology Humans Immunomodulation Innate immune response Interaction partners Molecular Sequence Data Phylogeny Pseudomonas aeruginosa Pseudomonas aeruginosa - physiology SARM Signal Transduction Sterile-alpha and Armadillo motif protein TLR signaling Toll-Like Receptors - physiology
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