Pharmacokinetics of Arundic Acid, an Astrocyte Modulating Agent, in Acute Ischemic Stroke

Arundic acid is an astrocyte modulating agent that improves neurological outcome in experimental acute stroke models. The pharmacokinetics of arundic acid in patients with acute ischemic stroke was investigated in a randomized, double‐blind study. Six groups of 8 to 9 patients each received 2, 4, 6,...

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Veröffentlicht in:	Journal of clinical pharmacology 2007-04, Vol.47 (4), p.445-452
Hauptverfasser:	Ishibashi, Hideyasu, Pettigrew, L. Creed, Funakoshi, Yosuke, Hiramatsu, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Age Factors Aged Aged, 80 and over Area Under Curve Arundic acid astrocyte Astrocytes Astrocytes - drug effects Astrocytes - metabolism Caprylates - administration & dosage Caprylates - blood Caprylates - pharmacokinetics Cerebral ischemia Dose-Response Relationship, Drug Double-Blind Method Female Half-Life Health aspects Humans Male Metabolic Clearance Rate Middle Aged Neuroprotective Agents - administration & dosage Neuroprotective Agents - blood Neuroprotective Agents - pharmacokinetics Patient outcomes Pharmacokinetics Stroke - drug therapy Stroke - metabolism
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