Eicosanoid Modulation in Advanced Lung Cancer: Cyclooxygenase-2 Expression Is a Positive Predictive Factor for Celecoxib + Chemotherapy—Cancer and Leukemia Group B Trial 30203

Increased expression of eicosanoids in cancer has been associated with adverse prognosis. We performed a randomized phase II trial to test the hypothesis that inhibitors of two eicosanoid pathways (cyclooxygenase-2 [COX-2], celecoxib and 5-lipoxygenase [5-LOX], zileuton) added to chemotherapy would...

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Veröffentlicht in:	Journal of clinical oncology 2008-02, Vol.26 (6), p.848-855
Hauptverfasser:	EDELMAN, Martin J, WATSON, Dee, BEDOR, Michelle, VOKES, Everett E, GREEN, Mark J, XIAOFEI WANG, MORRISON, Carl, KRATZKE, Robert A, JEWELL, Scott, HODGSON, Lydia, MAUER, Ann M, GAJRA, Ajeet, MASTERS, Gregory A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers, Tumor - metabolism Carboplatin - administration & dosage Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Celecoxib Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - therapeutic use Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Disease-Free Survival Drug Administration Schedule Eicosanoids - antagonists & inhibitors Eicosanoids - metabolism Female Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Hydroxyurea - analogs & derivatives Hydroxyurea - therapeutic use Immunohistochemistry Lipoxygenase Inhibitors - therapeutic use Logistic Models Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical sciences Middle Aged Multivariate Analysis Neoplasm Staging Pneumology Prognosis Prospective Studies Pyrazoles - therapeutic use Sulfonamides - therapeutic use Tumors Tumors of the respiratory system and mediastinum Up-Regulation
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