Differential expression of cardiac neurotrophic factors and sympathetic nerve ending abnormalities within the failing heart

Abstract In congestive heart failure (CHF), cardiac sympathetic nerve endings transdifferentiate from a balanced norepinephrine (NE) storage/release/uptake apparatus to a nerve that predominantly releases NE. Little is known about the neurotrophic factors that may trigger this process. In the presen...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2008-02, Vol.44 (2), p.380-387
Hauptverfasser:	Kreusser, Michael M, Buss, Sebastian J, Krebs, Jutta, Kinscherf, Ralf, Metz, Jürgen, Katus, Hugo A, Haass, Markus, Backs, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight Cardiovascular Congestive heart failure Dahl rats Gene Expression Profiling Gene Expression Regulation Heart Failure - genetics Heart Ventricles - metabolism Myocardium - metabolism Myocardium - pathology Nerve Endings - abnormalities Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Neurotrophic factors Norepinephrine - metabolism Norepinephrine Plasma Membrane Transport Proteins - genetics Norepinephrine Plasma Membrane Transport Proteins - metabolism Norepinephrine transporter Organ Size Rats Rats, Inbred Dahl RNA, Messenger - genetics RNA, Messenger - metabolism Sympathetic nervous system Sympathetic Nervous System - abnormalities Tritium
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