Blood Flow Redistribution During Exercise Contributes to Exercise Tolerance in Patients With Chronic Heart Failure
Background It is widely known that blood flow redistribution is impaired in patients with chronic heart failure (CHF). However, the relationship between exercise tolerance and the degree of blood flow redistribution is not fully understood. Whole-body thallium-201 chloride (201Tl) scintigraphy can e...
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| Veröffentlicht in: | Circulation Journal 2007, Vol.71(4), pp.465-470 |
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| creator | Miyazaki, Akihisa Adachi, Hitoshi Oshima, Shigeru Taniguchi, Koichi Hasegawa, Akira Kurabayashi, Masahiko |
| description | Background It is widely known that blood flow redistribution is impaired in patients with chronic heart failure (CHF). However, the relationship between exercise tolerance and the degree of blood flow redistribution is not fully understood. Whole-body thallium-201 chloride (201Tl) scintigraphy can estimate blood flow distribution. This study will evaluate the relationship between exercise tolerance and blood flow redistribution using whole-body scintigraphy in patients with CHF. Methods and Results Exercise stress whole-body thallium scintigraphy was performed in 19 patients with CHF (mean ejection fraction: 33.0%; peak oxygen uptake: 15.5 ml · min-1 · kg-1). Blood flow redistribution was quantified by comparing the regional thallium count (count/pixel) in the thigh and arm. We then assessed the relationship between these parameters and parameters obtained from cardiopulmonary exercise testing. 201Thallium-chloride uptake in the thigh increased during exercise compared to rest (p |
| doi_str_mv | 10.1253/circj.71.465 |
| format | Article |
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However, the relationship between exercise tolerance and the degree of blood flow redistribution is not fully understood. Whole-body thallium-201 chloride (201Tl) scintigraphy can estimate blood flow distribution. This study will evaluate the relationship between exercise tolerance and blood flow redistribution using whole-body scintigraphy in patients with CHF. Methods and Results Exercise stress whole-body thallium scintigraphy was performed in 19 patients with CHF (mean ejection fraction: 33.0%; peak oxygen uptake: 15.5 ml · min-1 · kg-1). Blood flow redistribution was quantified by comparing the regional thallium count (count/pixel) in the thigh and arm. We then assessed the relationship between these parameters and parameters obtained from cardiopulmonary exercise testing. 201Thallium-chloride uptake in the thigh increased during exercise compared to rest (p<0.05), while its uptake in the arm was not different between exercise and rest. Increased 201Tl uptake in the thigh during exercise was positively correlated with exercise tolerance (r=0.689). In contrast, 201Tl uptake in the arm was not correlated with exercise tolerance. Conclusions By using this method, it is concluded that blood flow redistribution to the exercising muscle increases as the exercise tolerance increases in patients with CHF. (Circ J 2007; 71: 465 - 470)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.71.465</identifier><identifier>PMID: 17384444</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Arm - blood supply ; Blood flow redistribution ; Cardiac Output, Low - diagnostic imaging ; Cardiac Output, Low - physiopathology ; Chronic Disease ; Chronic heart failure ; Exercise ; Exercise - physiology ; Exercise Tolerance - physiology ; Female ; Humans ; Male ; Middle Aged ; Oxygen Consumption - physiology ; Radionuclide Imaging ; Regional Blood Flow - physiology ; Stroke Volume - physiology ; Thallium ; Thigh - blood supply</subject><ispartof>Circulation Journal, 2007, Vol.71(4), pp.465-470</ispartof><rights>2007 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-9b5dbd3070d5f7bbd9ce824459e4e312bbfb089d2b4e8ef15976939857fa75c13</citedby><cites>FETCH-LOGICAL-c475t-9b5dbd3070d5f7bbd9ce824459e4e312bbfb089d2b4e8ef15976939857fa75c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17384444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyazaki, Akihisa</creatorcontrib><creatorcontrib>Adachi, Hitoshi</creatorcontrib><creatorcontrib>Oshima, Shigeru</creatorcontrib><creatorcontrib>Taniguchi, Koichi</creatorcontrib><creatorcontrib>Hasegawa, Akira</creatorcontrib><creatorcontrib>Kurabayashi, Masahiko</creatorcontrib><title>Blood Flow Redistribution During Exercise Contributes to Exercise Tolerance in Patients With Chronic Heart Failure</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background It is widely known that blood flow redistribution is impaired in patients with chronic heart failure (CHF). However, the relationship between exercise tolerance and the degree of blood flow redistribution is not fully understood. Whole-body thallium-201 chloride (201Tl) scintigraphy can estimate blood flow distribution. This study will evaluate the relationship between exercise tolerance and blood flow redistribution using whole-body scintigraphy in patients with CHF. Methods and Results Exercise stress whole-body thallium scintigraphy was performed in 19 patients with CHF (mean ejection fraction: 33.0%; peak oxygen uptake: 15.5 ml · min-1 · kg-1). Blood flow redistribution was quantified by comparing the regional thallium count (count/pixel) in the thigh and arm. We then assessed the relationship between these parameters and parameters obtained from cardiopulmonary exercise testing. 201Thallium-chloride uptake in the thigh increased during exercise compared to rest (p<0.05), while its uptake in the arm was not different between exercise and rest. Increased 201Tl uptake in the thigh during exercise was positively correlated with exercise tolerance (r=0.689). In contrast, 201Tl uptake in the arm was not correlated with exercise tolerance. Conclusions By using this method, it is concluded that blood flow redistribution to the exercising muscle increases as the exercise tolerance increases in patients with CHF. (Circ J 2007; 71: 465 - 470)</description><subject>Aged</subject><subject>Arm - blood supply</subject><subject>Blood flow redistribution</subject><subject>Cardiac Output, Low - diagnostic imaging</subject><subject>Cardiac Output, Low - physiopathology</subject><subject>Chronic Disease</subject><subject>Chronic heart failure</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen Consumption - physiology</subject><subject>Radionuclide Imaging</subject><subject>Regional Blood Flow - physiology</subject><subject>Stroke Volume - physiology</subject><subject>Thallium</subject><subject>Thigh - blood supply</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEFP3DAQRq0KBJRy6xn5xIksdmyv4yNdWKiEBKqoerRsZ8J6lbWp7ajw7wlkxXYOM6OZp-_wEPpOyYzWgl04n9x6JumMz8UXdEQZlxVvarL3sc8r1XB2iL7mvCakVkSoA3RIJWv4WEco_ehjbPGyj__wL2h9LsnbofgY8NWQfHjC1y-QnM-AFzFMT8i4xN39MfaQTHCAfcAPpngIJeM_vqzwYpVi8A7fgkkFL43vhwTf0H5n-gwn23mMfi-vHxe31d39zc_F5V3luBSlUla0tmVEklZ00tpWOWhqzoUCDozW1naWNKqtLYcGOiqUnCumGiE7I4Wj7BidTbnPKf4dIBe98dlB35sAcchaEkbmkrERPJ9Al2LOCTr9nPzGpFdNiX53rD8ca0n16HjET7e5g91Au4O3UkfgcgLWuZgn-ARGB9718F_a1MbQ3W9lkobA3gCYfpHR</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Miyazaki, Akihisa</creator><creator>Adachi, Hitoshi</creator><creator>Oshima, Shigeru</creator><creator>Taniguchi, Koichi</creator><creator>Hasegawa, Akira</creator><creator>Kurabayashi, Masahiko</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>Blood Flow Redistribution During Exercise Contributes to Exercise Tolerance in Patients With Chronic Heart Failure</title><author>Miyazaki, Akihisa ; Adachi, Hitoshi ; Oshima, Shigeru ; Taniguchi, Koichi ; Hasegawa, Akira ; Kurabayashi, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-9b5dbd3070d5f7bbd9ce824459e4e312bbfb089d2b4e8ef15976939857fa75c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Arm - blood supply</topic><topic>Blood flow redistribution</topic><topic>Cardiac Output, Low - diagnostic imaging</topic><topic>Cardiac Output, Low - physiopathology</topic><topic>Chronic Disease</topic><topic>Chronic heart failure</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen Consumption - physiology</topic><topic>Radionuclide Imaging</topic><topic>Regional Blood Flow - physiology</topic><topic>Stroke Volume - physiology</topic><topic>Thallium</topic><topic>Thigh - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyazaki, Akihisa</creatorcontrib><creatorcontrib>Adachi, Hitoshi</creatorcontrib><creatorcontrib>Oshima, Shigeru</creatorcontrib><creatorcontrib>Taniguchi, Koichi</creatorcontrib><creatorcontrib>Hasegawa, Akira</creatorcontrib><creatorcontrib>Kurabayashi, Masahiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyazaki, Akihisa</au><au>Adachi, Hitoshi</au><au>Oshima, Shigeru</au><au>Taniguchi, Koichi</au><au>Hasegawa, Akira</au><au>Kurabayashi, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood Flow Redistribution During Exercise Contributes to Exercise Tolerance in Patients With Chronic Heart Failure</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2007</date><risdate>2007</risdate><volume>71</volume><issue>4</issue><spage>465</spage><epage>470</epage><pages>465-470</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background It is widely known that blood flow redistribution is impaired in patients with chronic heart failure (CHF). However, the relationship between exercise tolerance and the degree of blood flow redistribution is not fully understood. Whole-body thallium-201 chloride (201Tl) scintigraphy can estimate blood flow distribution. This study will evaluate the relationship between exercise tolerance and blood flow redistribution using whole-body scintigraphy in patients with CHF. Methods and Results Exercise stress whole-body thallium scintigraphy was performed in 19 patients with CHF (mean ejection fraction: 33.0%; peak oxygen uptake: 15.5 ml · min-1 · kg-1). Blood flow redistribution was quantified by comparing the regional thallium count (count/pixel) in the thigh and arm. We then assessed the relationship between these parameters and parameters obtained from cardiopulmonary exercise testing. 201Thallium-chloride uptake in the thigh increased during exercise compared to rest (p<0.05), while its uptake in the arm was not different between exercise and rest. Increased 201Tl uptake in the thigh during exercise was positively correlated with exercise tolerance (r=0.689). In contrast, 201Tl uptake in the arm was not correlated with exercise tolerance. Conclusions By using this method, it is concluded that blood flow redistribution to the exercising muscle increases as the exercise tolerance increases in patients with CHF. (Circ J 2007; 71: 465 - 470)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>17384444</pmid><doi>10.1253/circj.71.465</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Arm - blood supply Blood flow redistribution Cardiac Output, Low - diagnostic imaging Cardiac Output, Low - physiopathology Chronic Disease Chronic heart failure Exercise Exercise - physiology Exercise Tolerance - physiology Female Humans Male Middle Aged Oxygen Consumption - physiology Radionuclide Imaging Regional Blood Flow - physiology Stroke Volume - physiology Thallium Thigh - blood supply |
| title | Blood Flow Redistribution During Exercise Contributes to Exercise Tolerance in Patients With Chronic Heart Failure |
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