T Box Riboswitch Antiterminator Affinity Modulated by tRNA Structural Elements

A unique RNA–RNA interaction occurs between uncharged tRNA and the untranslated mRNA leader region of bacterial T box genes. The interaction results in activation of a transcriptional antitermination molecular switch (riboswitch) by stabilizing an antiterminator RNA element and precluding formation...

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Veröffentlicht in:	Chemical biology & drug design 2007-02, Vol.69 (2), p.139-145
Hauptverfasser:	Means, John A., Wolf, Steffen, Agyeman, Akwasi, Burton, Jeremy S., Simson, Crystal M., Hines, Jennifer V.
Format:	Artikel
Sprache:	eng
Schlagworte:	antiterminator Base Pairing fluorescence Gram-Positive Bacteria - chemistry Gram-Positive Bacteria - genetics ligand screening Models, Molecular riboswitch RNA, Bacterial RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Transfer - chemistry RNA, Transfer - genetics Terminator Regions, Genetic - genetics tRNA
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