The effects of ibuprofen and the neurokinin-1 receptor antagonist GR205171A on Fos expression in the ferret trigeminal nucleus following tooth pulp stimulation

Abstract We have developed a model to study central changes following inflammation of the tooth pulp in the ferret and have examined Fos expression in the trigeminal nucleus following stimulation of non-inflamed and inflamed tooth pulps. The aim of this study was to establish the ability of this mod...

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Veröffentlicht in:	European journal of pain 2008-04, Vol.12 (3), p.385-394
Hauptverfasser:	Worsley, Matthew A, Clayton, Nick M, Bountra, Chas, Boissonade, Fiona M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia & Perioperative Care Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Cuspid Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase Inhibitors - therapeutic use Dental Pulp - innervation Drug Evaluation, Preclinical Electric Stimulation Ferrets Fos Gene Expression Regulation - drug effects Genes, fos - drug effects Ibuprofen Ibuprofen - pharmacology Ibuprofen - therapeutic use Mustela putorius furo Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurokinin-1 receptor Neurokinin-1 Receptor Antagonists Pain Medicine Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Proto-Oncogene Proteins c-fos - biosynthesis Pulpitis - drug therapy Pulpitis - genetics Pulpitis - physiopathology Receptors, Neurokinin-1 - physiology Substance P - analogs & derivatives Substance P - pharmacology Substance P - therapeutic use Tooth pulp Trigeminal Neuralgia - drug therapy Trigeminal Neuralgia - etiology Trigeminal Neuralgia - physiopathology Trigeminal Nuclei - metabolism Trigeminal Nuclei - physiopathology Trigeminal nucleus
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