Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies
Aims To examine the association between maternal glycated haemoglobin in the second half of diabetic pregnancies and the relative risk of delivering large‐for‐gestational‐age (LGA) babies, controlling for maternal body mass index (BMI) before pregnancy, weight gain, age, White class and smoking hab...
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| Veröffentlicht in: | Diabetic medicine 2007-04, Vol.24 (4), p.384-387 |
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| creator | Nielsen, G. L. Dethlefsen, C. Møller, M. Sørensen, H. T. |
| description | Aims To examine the association between maternal glycated haemoglobin in the second half of diabetic pregnancies and the relative risk of delivering large‐for‐gestational‐age (LGA) babies, controlling for maternal body mass index (BMI) before pregnancy, weight gain, age, White class and smoking habits.
Methods We identified all pregnant diabetic women in North Jutland County, Denmark from 1985 to 2003. Data on HbA1c values from the 20th gestational week to term were collected from medical records and the babies were classified as large, normal or small for gestational age. The association between glycated haemoglobin (HbA1c) and relative risk of delivering an LGA baby was quantified based on logistic regression models and stratified analysis controlling for the five covariates.
Results We included 209 singleton pregnancies with assessable HbA1c values of which 59%[95% confidence interval (CI) 52–65%] terminated with an LGA baby. Increasing levels of HbA1c, BMI and weight gain were all associated with increasing risk of delivering an LGA baby. Analyses stratified according to maternal BMI showed that the association between HbA1c and risk of delivering an LGA baby was restricted to pregnancies with pre‐pregnancy BMI > 23 kg/m2. We found no association between HbA1c and risk of delivering an LGA baby in pregnancies with lower BMI.
Conclusion The positive association between glycated haemoglobin and birth of an LGA baby seems to be restricted to women with BMI > 23 kg/m2. |
| doi_str_mv | 10.1111/j.1464-5491.2007.02103.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70304369</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70304369</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4353-fb248fe3cf4132ba5d7ca2e535e5eea88509fa6052d9be19c6bb862d31efca43</originalsourceid><addsrcrecordid>eNqNkctu1DAUhiNERYfCKyBvYEVS33JDYoFmSkFqQUgjsbROnOOMp5l4amfUydvwJCx4MpLOaMoSb3x0_H2-_VFEGE3YOC7XCZOZjFNZsoRTmieUMyqS_bNodlp4Hs1oLnksaM7Oo5chrCllvBTli-ic5UKkIziLft9Cj76DljTtoMe6JivAjWtaV9nuPdl6jBsMPfTWTdQD2mbVP_abDjo9HDukAdsR6GribbgjzpAWfIOxcf5fP4YGSQWVxfCBAFlAZ8OKaLdyvieh39XDpHJakmC7psXedWQ5bPHPL0ZqCxX2Vp_OHjd5FZ0ZaAO-Ps4X0fLz1XL-Jb75fv11_ukm1lKkIjYVl4VBoY1kgleQ1rkGjqlIMUWEokhpaSCjKa_LClmps6oqMl4LhkaDFBfRu8O2W-_ud-Nz1MYGjW0LHbpdUDkVVIqsHMHiAGrvQvBo1NbbDfhBMaqm6NRaTQmpKSE1Raceo1P7UX1zPGNXbbB-Eo9ZjcDbIwBBQ2v89AXhiSsywWWZj9zHA_dgWxz--wJqcXs1VaMfH3wbetyffPB3KstFnqqf365VOecLUWSF-iH-ApWdyBI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70304369</pqid></control><display><type>article</type><title>Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Nielsen, G. L. ; Dethlefsen, C. ; Møller, M. ; Sørensen, H. T.</creator><creatorcontrib>Nielsen, G. L. ; Dethlefsen, C. ; Møller, M. ; Sørensen, H. T.</creatorcontrib><description>Aims To examine the association between maternal glycated haemoglobin in the second half of diabetic pregnancies and the relative risk of delivering large‐for‐gestational‐age (LGA) babies, controlling for maternal body mass index (BMI) before pregnancy, weight gain, age, White class and smoking habits.
Methods We identified all pregnant diabetic women in North Jutland County, Denmark from 1985 to 2003. Data on HbA1c values from the 20th gestational week to term were collected from medical records and the babies were classified as large, normal or small for gestational age. The association between glycated haemoglobin (HbA1c) and relative risk of delivering an LGA baby was quantified based on logistic regression models and stratified analysis controlling for the five covariates.
Results We included 209 singleton pregnancies with assessable HbA1c values of which 59%[95% confidence interval (CI) 52–65%] terminated with an LGA baby. Increasing levels of HbA1c, BMI and weight gain were all associated with increasing risk of delivering an LGA baby. Analyses stratified according to maternal BMI showed that the association between HbA1c and risk of delivering an LGA baby was restricted to pregnancies with pre‐pregnancy BMI > 23 kg/m2. We found no association between HbA1c and risk of delivering an LGA baby in pregnancies with lower BMI.
Conclusion The positive association between glycated haemoglobin and birth of an LGA baby seems to be restricted to women with BMI > 23 kg/m2.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2007.02103.x</identifier><identifier>PMID: 17335464</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Body Mass Index ; Cohort Studies ; Denmark ; diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Fetal Macrosomia - etiology ; Fetal Macrosomia - physiopathology ; Gestational Age ; glycated haemoglobin ; Glycated Hemoglobin A - metabolism ; Humans ; large-for-gestational-age offspring ; Medical sciences ; Pregnancy ; Pregnancy in Diabetics - blood ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Risk Factors ; Weight Gain - physiology</subject><ispartof>Diabetic medicine, 2007-04, Vol.24 (4), p.384-387</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4353-fb248fe3cf4132ba5d7ca2e535e5eea88509fa6052d9be19c6bb862d31efca43</citedby><cites>FETCH-LOGICAL-c4353-fb248fe3cf4132ba5d7ca2e535e5eea88509fa6052d9be19c6bb862d31efca43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2007.02103.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2007.02103.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18632497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17335464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nielsen, G. L.</creatorcontrib><creatorcontrib>Dethlefsen, C.</creatorcontrib><creatorcontrib>Møller, M.</creatorcontrib><creatorcontrib>Sørensen, H. T.</creatorcontrib><title>Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims To examine the association between maternal glycated haemoglobin in the second half of diabetic pregnancies and the relative risk of delivering large‐for‐gestational‐age (LGA) babies, controlling for maternal body mass index (BMI) before pregnancy, weight gain, age, White class and smoking habits.
Methods We identified all pregnant diabetic women in North Jutland County, Denmark from 1985 to 2003. Data on HbA1c values from the 20th gestational week to term were collected from medical records and the babies were classified as large, normal or small for gestational age. The association between glycated haemoglobin (HbA1c) and relative risk of delivering an LGA baby was quantified based on logistic regression models and stratified analysis controlling for the five covariates.
Results We included 209 singleton pregnancies with assessable HbA1c values of which 59%[95% confidence interval (CI) 52–65%] terminated with an LGA baby. Increasing levels of HbA1c, BMI and weight gain were all associated with increasing risk of delivering an LGA baby. Analyses stratified according to maternal BMI showed that the association between HbA1c and risk of delivering an LGA baby was restricted to pregnancies with pre‐pregnancy BMI > 23 kg/m2. We found no association between HbA1c and risk of delivering an LGA baby in pregnancies with lower BMI.
Conclusion The positive association between glycated haemoglobin and birth of an LGA baby seems to be restricted to women with BMI > 23 kg/m2.</description><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cohort Studies</subject><subject>Denmark</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Fetal Macrosomia - etiology</subject><subject>Fetal Macrosomia - physiopathology</subject><subject>Gestational Age</subject><subject>glycated haemoglobin</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>large-for-gestational-age offspring</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - blood</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy Trimester, Third</subject><subject>Risk Factors</subject><subject>Weight Gain - physiology</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhiNERYfCKyBvYEVS33JDYoFmSkFqQUgjsbROnOOMp5l4amfUydvwJCx4MpLOaMoSb3x0_H2-_VFEGE3YOC7XCZOZjFNZsoRTmieUMyqS_bNodlp4Hs1oLnksaM7Oo5chrCllvBTli-ic5UKkIziLft9Cj76DljTtoMe6JivAjWtaV9nuPdl6jBsMPfTWTdQD2mbVP_abDjo9HDukAdsR6GribbgjzpAWfIOxcf5fP4YGSQWVxfCBAFlAZ8OKaLdyvieh39XDpHJakmC7psXedWQ5bPHPL0ZqCxX2Vp_OHjd5FZ0ZaAO-Ps4X0fLz1XL-Jb75fv11_ukm1lKkIjYVl4VBoY1kgleQ1rkGjqlIMUWEokhpaSCjKa_LClmps6oqMl4LhkaDFBfRu8O2W-_ud-Nz1MYGjW0LHbpdUDkVVIqsHMHiAGrvQvBo1NbbDfhBMaqm6NRaTQmpKSE1Raceo1P7UX1zPGNXbbB-Eo9ZjcDbIwBBQ2v89AXhiSsywWWZj9zHA_dgWxz--wJqcXs1VaMfH3wbetyffPB3KstFnqqf365VOecLUWSF-iH-ApWdyBI</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Nielsen, G. L.</creator><creator>Dethlefsen, C.</creator><creator>Møller, M.</creator><creator>Sørensen, H. T.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies</title><author>Nielsen, G. L. ; Dethlefsen, C. ; Møller, M. ; Sørensen, H. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4353-fb248fe3cf4132ba5d7ca2e535e5eea88509fa6052d9be19c6bb862d31efca43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cohort Studies</topic><topic>Denmark</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Fetal Macrosomia - etiology</topic><topic>Fetal Macrosomia - physiopathology</topic><topic>Gestational Age</topic><topic>glycated haemoglobin</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>large-for-gestational-age offspring</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - blood</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy Trimester, Third</topic><topic>Risk Factors</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nielsen, G. L.</creatorcontrib><creatorcontrib>Dethlefsen, C.</creatorcontrib><creatorcontrib>Møller, M.</creatorcontrib><creatorcontrib>Sørensen, H. T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nielsen, G. L.</au><au>Dethlefsen, C.</au><au>Møller, M.</au><au>Sørensen, H. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2007-04</date><risdate>2007</risdate><volume>24</volume><issue>4</issue><spage>384</spage><epage>387</epage><pages>384-387</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims To examine the association between maternal glycated haemoglobin in the second half of diabetic pregnancies and the relative risk of delivering large‐for‐gestational‐age (LGA) babies, controlling for maternal body mass index (BMI) before pregnancy, weight gain, age, White class and smoking habits.
Methods We identified all pregnant diabetic women in North Jutland County, Denmark from 1985 to 2003. Data on HbA1c values from the 20th gestational week to term were collected from medical records and the babies were classified as large, normal or small for gestational age. The association between glycated haemoglobin (HbA1c) and relative risk of delivering an LGA baby was quantified based on logistic regression models and stratified analysis controlling for the five covariates.
Results We included 209 singleton pregnancies with assessable HbA1c values of which 59%[95% confidence interval (CI) 52–65%] terminated with an LGA baby. Increasing levels of HbA1c, BMI and weight gain were all associated with increasing risk of delivering an LGA baby. Analyses stratified according to maternal BMI showed that the association between HbA1c and risk of delivering an LGA baby was restricted to pregnancies with pre‐pregnancy BMI > 23 kg/m2. We found no association between HbA1c and risk of delivering an LGA baby in pregnancies with lower BMI.
Conclusion The positive association between glycated haemoglobin and birth of an LGA baby seems to be restricted to women with BMI > 23 kg/m2.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17335464</pmid><doi>10.1111/j.1464-5491.2007.02103.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Diabetic medicine, 2007-04, Vol.24 (4), p.384-387 |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Biological and medical sciences Body Mass Index Cohort Studies Denmark diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fetal Macrosomia - etiology Fetal Macrosomia - physiopathology Gestational Age glycated haemoglobin Glycated Hemoglobin A - metabolism Humans large-for-gestational-age offspring Medical sciences Pregnancy Pregnancy in Diabetics - blood Pregnancy Trimester, Second Pregnancy Trimester, Third Risk Factors Weight Gain - physiology |
| title | Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies |
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