Effects of carvacrol upon the liver of rats undergoing partial hepatectomy
The present study aims to investigate the possible effects of carvacrol obtained from origanum oil upon the regenerative feature of the liver subsequent to partial hepatectomy in rats. Male Wistar Albino rats, weighing 230±30 g, were divided into three experiment groups. Group I ( n=8) were used as...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2008-03, Vol.15 (3), p.226-229 |
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| creator | Uyanoglu, Mustafa Canbek, Mediha Aral, Erinc Husnu Can Baser, K. |
| description | The present study aims to investigate the possible effects of carvacrol obtained from origanum oil upon the regenerative feature of the liver subsequent to partial hepatectomy in rats.
Male Wistar Albino rats, weighing 230±30
g, were divided into three experiment groups. Group I (
n=8) were used as sham operation group. Group II (
n=8) were applied saline solution and hepatectomy. Carvacrol and hepatectomy (73
mg/kg) were applied to Group III (
n=8). One dose of test material was injected 1
h before 68% partial hepatectomy. At the end of the experiments, blood and organs were removed. The liver regeneration rate of the rats was calculated measuring the weights of their liver before and after the hepatectomy. Hematoxylin and eosin, interleukin-6 (IL-6) and proliferating cell nuclear antigen (PCNA) treatments were applied to liver sections. Aspartate transaminase (AST), alanine transaminase (ALT), tumor necrosis factor-alpha (TNF-
α) and IL-6 levels were determined in serum samples.
The liver regeneration, mitotic index and PCNA index increased significantly in rats of Group III over the Group II at the 72nd hour after partial hepatectomy. Histological evaluations were also similar with these results of PCNA and mitotic indexes. In AST, ALT, TNF-
α and IL-6 levels, there was no statistically significant difference.
According to these results, it is concluded that carvacrol increases the liver regeneration rate. |
| doi_str_mv | 10.1016/j.phymed.2007.06.010 |
| format | Article |
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Male Wistar Albino rats, weighing 230±30
g, were divided into three experiment groups. Group I (
n=8) were used as sham operation group. Group II (
n=8) were applied saline solution and hepatectomy. Carvacrol and hepatectomy (73
mg/kg) were applied to Group III (
n=8). One dose of test material was injected 1
h before 68% partial hepatectomy. At the end of the experiments, blood and organs were removed. The liver regeneration rate of the rats was calculated measuring the weights of their liver before and after the hepatectomy. Hematoxylin and eosin, interleukin-6 (IL-6) and proliferating cell nuclear antigen (PCNA) treatments were applied to liver sections. Aspartate transaminase (AST), alanine transaminase (ALT), tumor necrosis factor-alpha (TNF-
α) and IL-6 levels were determined in serum samples.
The liver regeneration, mitotic index and PCNA index increased significantly in rats of Group III over the Group II at the 72nd hour after partial hepatectomy. Histological evaluations were also similar with these results of PCNA and mitotic indexes. In AST, ALT, TNF-
α and IL-6 levels, there was no statistically significant difference.
According to these results, it is concluded that carvacrol increases the liver regeneration rate.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2007.06.010</identifier><identifier>PMID: 17689059</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Carvacrol ; Cell Proliferation - drug effects ; Essences and essential oils ; Health aspects ; Hepatectomy ; Hepatocytes - drug effects ; Injuries ; Liver ; Liver - drug effects ; Liver - growth & development ; Liver regeneration ; Liver Regeneration - drug effects ; Male ; Medical examination ; Mitotic Index ; Monoterpenes - pharmacology ; Oregano ; Origanum - chemistry ; Origanum onites ; Partial hepatectomy ; Plant Extracts - pharmacology ; Properties ; Random Allocation ; Rat ; Rats ; Rats, Wistar</subject><ispartof>Phytomedicine (Stuttgart), 2008-03, Vol.15 (3), p.226-229</ispartof><rights>2007 Elsevier GmbH</rights><rights>COPYRIGHT 2008 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-8ec973eea92e5fe673f5958295413d9ff9ac52ae95f935898a27c126f21b97673</citedby><cites>FETCH-LOGICAL-c465t-8ec973eea92e5fe673f5958295413d9ff9ac52ae95f935898a27c126f21b97673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phymed.2007.06.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17689059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uyanoglu, Mustafa</creatorcontrib><creatorcontrib>Canbek, Mediha</creatorcontrib><creatorcontrib>Aral, Erinc</creatorcontrib><creatorcontrib>Husnu Can Baser, K.</creatorcontrib><title>Effects of carvacrol upon the liver of rats undergoing partial hepatectomy</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>The present study aims to investigate the possible effects of carvacrol obtained from origanum oil upon the regenerative feature of the liver subsequent to partial hepatectomy in rats.
Male Wistar Albino rats, weighing 230±30
g, were divided into three experiment groups. Group I (
n=8) were used as sham operation group. Group II (
n=8) were applied saline solution and hepatectomy. Carvacrol and hepatectomy (73
mg/kg) were applied to Group III (
n=8). One dose of test material was injected 1
h before 68% partial hepatectomy. At the end of the experiments, blood and organs were removed. The liver regeneration rate of the rats was calculated measuring the weights of their liver before and after the hepatectomy. Hematoxylin and eosin, interleukin-6 (IL-6) and proliferating cell nuclear antigen (PCNA) treatments were applied to liver sections. Aspartate transaminase (AST), alanine transaminase (ALT), tumor necrosis factor-alpha (TNF-
α) and IL-6 levels were determined in serum samples.
The liver regeneration, mitotic index and PCNA index increased significantly in rats of Group III over the Group II at the 72nd hour after partial hepatectomy. Histological evaluations were also similar with these results of PCNA and mitotic indexes. In AST, ALT, TNF-
α and IL-6 levels, there was no statistically significant difference.
According to these results, it is concluded that carvacrol increases the liver regeneration rate.</description><subject>Animals</subject><subject>Carvacrol</subject><subject>Cell Proliferation - drug effects</subject><subject>Essences and essential oils</subject><subject>Health aspects</subject><subject>Hepatectomy</subject><subject>Hepatocytes - drug effects</subject><subject>Injuries</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - growth & development</subject><subject>Liver regeneration</subject><subject>Liver Regeneration - drug effects</subject><subject>Male</subject><subject>Medical examination</subject><subject>Mitotic Index</subject><subject>Monoterpenes - pharmacology</subject><subject>Oregano</subject><subject>Origanum - chemistry</subject><subject>Origanum onites</subject><subject>Partial hepatectomy</subject><subject>Plant Extracts - pharmacology</subject><subject>Properties</subject><subject>Random Allocation</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFq3DAQhkVoSbZJ3iAUQyE3uyPbsqxLIISkaQn00kBuQpFHu1psy5HshX37yHgJFJagg0Dz_TNoPkKuKGQUaPVzmw2bfYdNlgPwDKoMKJyQFa1onYJgL1_ICkRZppzS4ox8C2ELQEvB4ZScUV7VAphYkT_3xqAeQ-JMopXfKe1dm0yD65Nxg0lrd-jnmleRmfoG_drZfp0Myo9WtckGBzXGBq7bX5CvRrUBLw_3OXl-uP9395g-_f31--72KdVlxca0Ri14gahEjsxgxQvDBKtzwUpaNMIYoTTLFQpmRMFqUauca5pXJqevgkf8nFwvfQfv3iYMo-xs0Ni2qkc3BcmhgIKKOoI_FnCtWpS2N270Ss-wvKWcC6hLlkcqPUKtsUevWtejsfH5Pz47wsfTYGf10UC5BOJqQ_Bo5OBtp_xeUpCzSrmVi0o5q5RQyagyxr4fvjm9zrWP0MFdBG4WAOOydxa9DNpir7GxPhqRjbOfT3gHcUmvmA</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Uyanoglu, Mustafa</creator><creator>Canbek, Mediha</creator><creator>Aral, Erinc</creator><creator>Husnu Can Baser, K.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Effects of carvacrol upon the liver of rats undergoing partial hepatectomy</title><author>Uyanoglu, Mustafa ; Canbek, Mediha ; Aral, Erinc ; Husnu Can Baser, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-8ec973eea92e5fe673f5958295413d9ff9ac52ae95f935898a27c126f21b97673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Carvacrol</topic><topic>Cell Proliferation - drug effects</topic><topic>Essences and essential oils</topic><topic>Health aspects</topic><topic>Hepatectomy</topic><topic>Hepatocytes - drug effects</topic><topic>Injuries</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - growth & development</topic><topic>Liver regeneration</topic><topic>Liver Regeneration - drug effects</topic><topic>Male</topic><topic>Medical examination</topic><topic>Mitotic Index</topic><topic>Monoterpenes - pharmacology</topic><topic>Oregano</topic><topic>Origanum - chemistry</topic><topic>Origanum onites</topic><topic>Partial hepatectomy</topic><topic>Plant Extracts - pharmacology</topic><topic>Properties</topic><topic>Random Allocation</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uyanoglu, Mustafa</creatorcontrib><creatorcontrib>Canbek, Mediha</creatorcontrib><creatorcontrib>Aral, Erinc</creatorcontrib><creatorcontrib>Husnu Can Baser, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uyanoglu, Mustafa</au><au>Canbek, Mediha</au><au>Aral, Erinc</au><au>Husnu Can Baser, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of carvacrol upon the liver of rats undergoing partial hepatectomy</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>15</volume><issue>3</issue><spage>226</spage><epage>229</epage><pages>226-229</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>The present study aims to investigate the possible effects of carvacrol obtained from origanum oil upon the regenerative feature of the liver subsequent to partial hepatectomy in rats.
Male Wistar Albino rats, weighing 230±30
g, were divided into three experiment groups. Group I (
n=8) were used as sham operation group. Group II (
n=8) were applied saline solution and hepatectomy. Carvacrol and hepatectomy (73
mg/kg) were applied to Group III (
n=8). One dose of test material was injected 1
h before 68% partial hepatectomy. At the end of the experiments, blood and organs were removed. The liver regeneration rate of the rats was calculated measuring the weights of their liver before and after the hepatectomy. Hematoxylin and eosin, interleukin-6 (IL-6) and proliferating cell nuclear antigen (PCNA) treatments were applied to liver sections. Aspartate transaminase (AST), alanine transaminase (ALT), tumor necrosis factor-alpha (TNF-
α) and IL-6 levels were determined in serum samples.
The liver regeneration, mitotic index and PCNA index increased significantly in rats of Group III over the Group II at the 72nd hour after partial hepatectomy. Histological evaluations were also similar with these results of PCNA and mitotic indexes. In AST, ALT, TNF-
α and IL-6 levels, there was no statistically significant difference.
According to these results, it is concluded that carvacrol increases the liver regeneration rate.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>17689059</pmid><doi>10.1016/j.phymed.2007.06.010</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Carvacrol Cell Proliferation - drug effects Essences and essential oils Health aspects Hepatectomy Hepatocytes - drug effects Injuries Liver Liver - drug effects Liver - growth & development Liver regeneration Liver Regeneration - drug effects Male Medical examination Mitotic Index Monoterpenes - pharmacology Oregano Origanum - chemistry Origanum onites Partial hepatectomy Plant Extracts - pharmacology Properties Random Allocation Rat Rats Rats, Wistar |
| title | Effects of carvacrol upon the liver of rats undergoing partial hepatectomy |
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