Glutamatergic Inputs in the Hypothalamic Paraventricular Nucleus Maintain Sympathetic Vasomotor Tone in Hypertension

The paraventricular nucleus (PVN) of the hypothalamus is critical to the regulation of sympathetic output. The PVN hyperactivity is known to cause increased sympathetic nerve activity in spontaneously hypertensive rats (SHRs). The purpose of this study was to determine whether glutamatergic input to...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-04, Vol.49 (4), p.916-925
Hauptverfasser:	Li, De-Pei, Pan, Hui-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - administration & dosage 2-Amino-5-phosphonovalerate - pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione - administration & dosage 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology GABA Antagonists - administration & dosage GABA Antagonists - pharmacology Glutamic Acid - metabolism Heart Rate - drug effects Hemodynamics. Rheology Hypertension - physiopathology Kynurenic Acid - administration & dosage Kynurenic Acid - pharmacology Male Medical sciences Microinjections Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - physiopathology Pyridazines - administration & dosage Pyridazines - pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology Vasomotor System - drug effects Vasomotor System - physiopathology Vertebrates: cardiovascular system
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