5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

A series of 5-phenyl-substituted- N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-02, Vol.18 (4), p.1478-1483
Hauptverfasser:	Watanabe, Kazutoshi, Morinaka, Yasuhiro, Hayashi, Yoshio, Shinoda, Masaki, Nishi, Hiroyoshi, Fukushima, Nobuko, Watanabe, Toshiaki, Ishibashi, Akira, Yuki, Satoshi, Tanaka, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Biological and medical sciences Free Radical Scavengers - chemical synthesis Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Imidazolin-2-one Imidazolines - chemical synthesis Imidazolines - chemistry Imidazolines - pharmacology Lipid Peroxidation - drug effects Medical sciences Memory - drug effects Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Radical scavenger Rats Rats, Wistar Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A series of 5-phenyl-substituted- N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2007.12.064