Cysteine-674 of the Sarco/Endoplasmic Reticulum Calcium ATPase Is Required for the Inhibition of Cell Migration by Nitric Oxide

OBJECTIVES—Nitric oxide inhibits smooth muscle cell migration after arterial injury, but the detailed mechanism is not fully understood. The sarco/endoplasmic reticulum calcium ATPase (SERCA) lowers cell Ca by increasing intracellular Ca uptake and inhibiting extracellular Ca influx. Our previous st...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-04, Vol.27 (4), p.783-790
Hauptverfasser:	Ying, Jia, Tong, XiaoYong, Pimentel, David R, Weisbrod, Robert M, Trucillo, Mario P, Adachi, Takeshi, Cohen, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aorta - cytology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Calcium - metabolism Cardiology. Vascular system Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Coronary heart disease Cyclic GMP - metabolism Cysteine Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fundamental and applied biological sciences. Psychology Glutathione - metabolism Heart Humans Medical sciences Muscle, Smooth, Vascular - cytology Mutation Myocytes, Smooth Muscle - physiology Nitric Oxide - metabolism Nitric Oxide - pharmacology Nitric Oxide Synthase Type II - metabolism Oxidation-Reduction Rats Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Transfection Vertebrates: cardiovascular system
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