Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats

We investigated the role played by catecholamine-dependent pathways in modulating the ability of centrally administered corticotropin releasing factor (CRF) to activate sympatho-adrenomedullay outflow, using urethane-anesthetized rats. The CRF (1.5 nmol/animal, i.c.v.)-induced elevations of both pla...

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Veröffentlicht in:	Life sciences (1973) 2008-02, Vol.82 (9), p.487-494
Hauptverfasser:	Yorimitsu, Mieko, Okada, Shoshiro, Yamaguchi-Shima, Naoko, Shimizu, Takahiro, Arai, Junichi, Yokotani, Kunihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Medulla - drug effects Adrenal Medulla - innervation Adrenal Medulla - metabolism Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - administration & dosage Adrenergic alpha-Antagonists - pharmacology Adrenergic beta-Antagonists - pharmacology Adrenoceptor Anesthesia Animals Brain Clonidine - administration & dosage Clonidine - pharmacology Corticotropin-releasing factor Corticotropin-Releasing Hormone - administration & dosage Corticotropin-Releasing Hormone - pharmacology Dose-Response Relationship, Drug Epinephrine - blood Injections, Intraventricular Isoquinolines - administration & dosage Isoquinolines - pharmacology Male Naphthyridines - administration & dosage Naphthyridines - pharmacology Norepinephrine - blood Phentolamine - administration & dosage Phentolamine - pharmacology Plasma catecholamine Rats Rats, Wistar Receptors, Adrenergic - physiology Sotalol - administration & dosage Sotalol - pharmacology Sympathetic Nervous System - physiology Time Factors
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