Phosphorylation of GRK2 by PKA augments GRK2-mediated phosphorylation, internalization, and desensitization of VPAC2 receptors in smooth muscle

Departments of Physiology and Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia Submitted 1 June 2007 ; accepted in final form 7 December 2007 The smooth muscle of the gut expresses mainly G s protein-coupled vasoactive intestinal peptide (VIP)/pituit...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2008-02, Vol.294 (2), p.C477-C487
Hauptverfasser:	Murthy, Karnam S, Mahavadi, Sunila, Huang, Jiean, Zhou, Huiping, Sriwai, Wimolpak
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive - physiology Cells, Cultured Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Dose-Response Relationship, Drug Endocytosis - drug effects Endocytosis - physiology Feedback, Physiological - drug effects Feedback, Physiological - physiology G-Protein-Coupled Receptor Kinase 2 - chemistry G-Protein-Coupled Receptor Kinase 2 - genetics G-Protein-Coupled Receptor Kinase 2 - metabolism Mutation - genetics Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Phosphorylation - drug effects Rabbits Radioligand Assay Receptors, Vasoactive Intestinal Peptide, Type II - drug effects Receptors, Vasoactive Intestinal Peptide, Type II - metabolism Signal Transduction - drug effects Signal Transduction - physiology Stomach - cytology Stomach - metabolism Vasoactive Intestinal Peptide - metabolism Vasoactive Intestinal Peptide - pharmacology
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