Histologic study of incorporation and resorption of a bone cement–collagen composite: an in vivo study in the minipig
Objective Calcium phosphates are clinically established as bone defect fillers. They have the capability of osseoconduction and are characterized by a slow resorption process. The present study evaluated the suitability of a newly developed calcium phosphate cement modified with collagen type I. Stu...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2008-03, Vol.105 (3), p.e9-e14 |
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| creator | Mai, Ronald, MD, DMD Reinstorf, Antje, MASc, Dr.rer.nat Pilling, Eckart, MD, DMD Hlawitschka, Matthias, MD, DMD Jung, Roland, VetMD Gelinsky, Michael, MASc, Dr.rer.nat Schneider, Matthias, MD, DMD Loukota, Richard, FDSRCS, FRCS Pompe, Wolfgang, PhD Eckelt, Uwe, MD, DMD, PhD Stadlinger, Bernd, MD, DMD |
| description | Objective Calcium phosphates are clinically established as bone defect fillers. They have the capability of osseoconduction and are characterized by a slow resorption process. The present study evaluated the suitability of a newly developed calcium phosphate cement modified with collagen type I. Study design The modified cement paste was inserted in differently designed defects of 10 minipigs. Further, an alveolar ridge augmentation was performed, applying the cement paste. The cement hardened in situ during the operation, forming a hydroxyapatite collagen composite. Animals were sacrificed after 1, 3, 6, 12, and 18 months. The tissue integration and resorption process was then evaluated using nondecalcified microsections. All animals were evaluated for histology. Results The implanted material showed osseoconductive characteristics. Resorption started from the edge of the defect zone, and bone substitution followed rapidly. Twelve months after placement of the cement, complete remodeling was observed. Conclusion It can be concluded that the applied hydroxyapatite-collagen cement composite shows good resorption and bone integration. |
| doi_str_mv | 10.1016/j.tripleo.2007.09.016 |
| format | Article |
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They have the capability of osseoconduction and are characterized by a slow resorption process. The present study evaluated the suitability of a newly developed calcium phosphate cement modified with collagen type I. Study design The modified cement paste was inserted in differently designed defects of 10 minipigs. Further, an alveolar ridge augmentation was performed, applying the cement paste. The cement hardened in situ during the operation, forming a hydroxyapatite collagen composite. Animals were sacrificed after 1, 3, 6, 12, and 18 months. The tissue integration and resorption process was then evaluated using nondecalcified microsections. All animals were evaluated for histology. Results The implanted material showed osseoconductive characteristics. Resorption started from the edge of the defect zone, and bone substitution followed rapidly. Twelve months after placement of the cement, complete remodeling was observed. Conclusion It can be concluded that the applied hydroxyapatite-collagen cement composite shows good resorption and bone integration.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/j.tripleo.2007.09.016</identifier><identifier>PMID: 18280955</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Absorbable Implants ; Alveolar Process - metabolism ; Alveolar Ridge Augmentation - methods ; Animals ; Bone Cements - pharmacokinetics ; Bone Cements - pharmacology ; Bone Regeneration - drug effects ; Bone Substitutes - pharmacokinetics ; Bone Substitutes - pharmacology ; Calcium Phosphates - pharmacokinetics ; Calcium Phosphates - pharmacology ; Cattle ; Collagen Type I - pharmacokinetics ; Collagen Type I - pharmacology ; Dentistry ; Drug Combinations ; Hydroxyapatites - pharmacokinetics ; Hydroxyapatites - pharmacology ; Organic Chemicals - pharmacokinetics ; Organic Chemicals - pharmacology ; Surgery ; Swine ; Swine, Miniature</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2008-03, Vol.105 (3), p.e9-e14</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-3716ab5de9eb58943efc9f3fea76769cc1486a41fd31aa2755166d1ba26a47863</citedby><cites>FETCH-LOGICAL-c418t-3716ab5de9eb58943efc9f3fea76769cc1486a41fd31aa2755166d1ba26a47863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tripleo.2007.09.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18280955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mai, Ronald, MD, DMD</creatorcontrib><creatorcontrib>Reinstorf, Antje, MASc, Dr.rer.nat</creatorcontrib><creatorcontrib>Pilling, Eckart, MD, DMD</creatorcontrib><creatorcontrib>Hlawitschka, Matthias, MD, DMD</creatorcontrib><creatorcontrib>Jung, Roland, VetMD</creatorcontrib><creatorcontrib>Gelinsky, Michael, MASc, Dr.rer.nat</creatorcontrib><creatorcontrib>Schneider, Matthias, MD, DMD</creatorcontrib><creatorcontrib>Loukota, Richard, FDSRCS, FRCS</creatorcontrib><creatorcontrib>Pompe, Wolfgang, PhD</creatorcontrib><creatorcontrib>Eckelt, Uwe, MD, DMD, PhD</creatorcontrib><creatorcontrib>Stadlinger, Bernd, MD, DMD</creatorcontrib><title>Histologic study of incorporation and resorption of a bone cement–collagen composite: an in vivo study in the minipig</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objective Calcium phosphates are clinically established as bone defect fillers. They have the capability of osseoconduction and are characterized by a slow resorption process. The present study evaluated the suitability of a newly developed calcium phosphate cement modified with collagen type I. Study design The modified cement paste was inserted in differently designed defects of 10 minipigs. Further, an alveolar ridge augmentation was performed, applying the cement paste. The cement hardened in situ during the operation, forming a hydroxyapatite collagen composite. Animals were sacrificed after 1, 3, 6, 12, and 18 months. The tissue integration and resorption process was then evaluated using nondecalcified microsections. All animals were evaluated for histology. Results The implanted material showed osseoconductive characteristics. Resorption started from the edge of the defect zone, and bone substitution followed rapidly. Twelve months after placement of the cement, complete remodeling was observed. Conclusion It can be concluded that the applied hydroxyapatite-collagen cement composite shows good resorption and bone integration.</description><subject>Absorbable Implants</subject><subject>Alveolar Process - metabolism</subject><subject>Alveolar Ridge Augmentation - methods</subject><subject>Animals</subject><subject>Bone Cements - pharmacokinetics</subject><subject>Bone Cements - pharmacology</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone Substitutes - pharmacokinetics</subject><subject>Bone Substitutes - pharmacology</subject><subject>Calcium Phosphates - pharmacokinetics</subject><subject>Calcium Phosphates - pharmacology</subject><subject>Cattle</subject><subject>Collagen Type I - pharmacokinetics</subject><subject>Collagen Type I - pharmacology</subject><subject>Dentistry</subject><subject>Drug Combinations</subject><subject>Hydroxyapatites - pharmacokinetics</subject><subject>Hydroxyapatites - pharmacology</subject><subject>Organic Chemicals - pharmacokinetics</subject><subject>Organic Chemicals - pharmacology</subject><subject>Surgery</subject><subject>Swine</subject><subject>Swine, Miniature</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUUGO1DAQtBCIXRaeAPKJW0I7TpyYAwitgEVaiQMgcbMcpzN4SOxgO4Pmxh_4IS_Bw0RC4sLJ7nJVdbuakMcMSgZMPNuXKdhlQl9WAG0JsszoHXLJmqoruGw-3813aGVRMagvyIMY9wAguJT3yQXrqg5k01yS7zc2Jj_5nTU0pnU4Uj9S64wPiw86We-odgMNGDPyp8zvmvbeITU4o0u_fvw0fpr0Dh01fl58tAmfZ1W2oQd78JtvrtIXpLN1drG7h-TeqKeIj7bzinx68_rj9U1x-_7tu-tXt4WpWZcK3jKh-2ZAiX3TyZrjaOTIR9StaIU0htWd0DUbB860rtqmYUIMrNdVRttO8Cvy9Oy7BP9txZjUbKPBPK9Dv0bVAgfGoMvE5kw0wccYcFRLsLMOR8VAnRJXe7Ulrk6JK5Aqo1n3ZGuw9jMOf1VbxJnw8kzA_M2DxaCisegMDjagSWrw9r8tXvzjYKacotHTVzxi3Ps1uJyhYipWCtSH09pPW4c2mwjg_Ddd76z6</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Mai, Ronald, MD, DMD</creator><creator>Reinstorf, Antje, MASc, Dr.rer.nat</creator><creator>Pilling, Eckart, MD, DMD</creator><creator>Hlawitschka, Matthias, MD, DMD</creator><creator>Jung, Roland, VetMD</creator><creator>Gelinsky, Michael, MASc, Dr.rer.nat</creator><creator>Schneider, Matthias, MD, DMD</creator><creator>Loukota, Richard, FDSRCS, FRCS</creator><creator>Pompe, Wolfgang, PhD</creator><creator>Eckelt, Uwe, MD, DMD, PhD</creator><creator>Stadlinger, Bernd, MD, DMD</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Histologic study of incorporation and resorption of a bone cement–collagen composite: an in vivo study in the minipig</title><author>Mai, Ronald, MD, DMD ; Reinstorf, Antje, MASc, Dr.rer.nat ; Pilling, Eckart, MD, DMD ; Hlawitschka, Matthias, MD, DMD ; Jung, Roland, VetMD ; Gelinsky, Michael, MASc, Dr.rer.nat ; Schneider, Matthias, MD, DMD ; Loukota, Richard, FDSRCS, FRCS ; Pompe, Wolfgang, PhD ; Eckelt, Uwe, MD, DMD, PhD ; Stadlinger, Bernd, MD, DMD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-3716ab5de9eb58943efc9f3fea76769cc1486a41fd31aa2755166d1ba26a47863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Absorbable Implants</topic><topic>Alveolar Process - metabolism</topic><topic>Alveolar Ridge Augmentation - methods</topic><topic>Animals</topic><topic>Bone Cements - pharmacokinetics</topic><topic>Bone Cements - pharmacology</topic><topic>Bone Regeneration - drug effects</topic><topic>Bone Substitutes - pharmacokinetics</topic><topic>Bone Substitutes - pharmacology</topic><topic>Calcium Phosphates - pharmacokinetics</topic><topic>Calcium Phosphates - pharmacology</topic><topic>Cattle</topic><topic>Collagen Type I - pharmacokinetics</topic><topic>Collagen Type I - pharmacology</topic><topic>Dentistry</topic><topic>Drug Combinations</topic><topic>Hydroxyapatites - pharmacokinetics</topic><topic>Hydroxyapatites - pharmacology</topic><topic>Organic Chemicals - pharmacokinetics</topic><topic>Organic Chemicals - pharmacology</topic><topic>Surgery</topic><topic>Swine</topic><topic>Swine, Miniature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mai, Ronald, MD, DMD</creatorcontrib><creatorcontrib>Reinstorf, Antje, MASc, Dr.rer.nat</creatorcontrib><creatorcontrib>Pilling, Eckart, MD, DMD</creatorcontrib><creatorcontrib>Hlawitschka, Matthias, MD, DMD</creatorcontrib><creatorcontrib>Jung, Roland, VetMD</creatorcontrib><creatorcontrib>Gelinsky, Michael, MASc, Dr.rer.nat</creatorcontrib><creatorcontrib>Schneider, Matthias, MD, DMD</creatorcontrib><creatorcontrib>Loukota, Richard, FDSRCS, FRCS</creatorcontrib><creatorcontrib>Pompe, Wolfgang, PhD</creatorcontrib><creatorcontrib>Eckelt, Uwe, MD, DMD, PhD</creatorcontrib><creatorcontrib>Stadlinger, Bernd, MD, DMD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mai, Ronald, MD, DMD</au><au>Reinstorf, Antje, MASc, Dr.rer.nat</au><au>Pilling, Eckart, MD, DMD</au><au>Hlawitschka, Matthias, MD, DMD</au><au>Jung, Roland, VetMD</au><au>Gelinsky, Michael, MASc, Dr.rer.nat</au><au>Schneider, Matthias, MD, DMD</au><au>Loukota, Richard, FDSRCS, FRCS</au><au>Pompe, Wolfgang, PhD</au><au>Eckelt, Uwe, MD, DMD, PhD</au><au>Stadlinger, Bernd, MD, DMD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic study of incorporation and resorption of a bone cement–collagen composite: an in vivo study in the minipig</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>105</volume><issue>3</issue><spage>e9</spage><epage>e14</epage><pages>e9-e14</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objective Calcium phosphates are clinically established as bone defect fillers. They have the capability of osseoconduction and are characterized by a slow resorption process. The present study evaluated the suitability of a newly developed calcium phosphate cement modified with collagen type I. Study design The modified cement paste was inserted in differently designed defects of 10 minipigs. Further, an alveolar ridge augmentation was performed, applying the cement paste. The cement hardened in situ during the operation, forming a hydroxyapatite collagen composite. Animals were sacrificed after 1, 3, 6, 12, and 18 months. The tissue integration and resorption process was then evaluated using nondecalcified microsections. All animals were evaluated for histology. Results The implanted material showed osseoconductive characteristics. Resorption started from the edge of the defect zone, and bone substitution followed rapidly. Twelve months after placement of the cement, complete remodeling was observed. Conclusion It can be concluded that the applied hydroxyapatite-collagen cement composite shows good resorption and bone integration.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>18280955</pmid><doi>10.1016/j.tripleo.2007.09.016</doi></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2008-03, Vol.105 (3), p.e9-e14 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Absorbable Implants Alveolar Process - metabolism Alveolar Ridge Augmentation - methods Animals Bone Cements - pharmacokinetics Bone Cements - pharmacology Bone Regeneration - drug effects Bone Substitutes - pharmacokinetics Bone Substitutes - pharmacology Calcium Phosphates - pharmacokinetics Calcium Phosphates - pharmacology Cattle Collagen Type I - pharmacokinetics Collagen Type I - pharmacology Dentistry Drug Combinations Hydroxyapatites - pharmacokinetics Hydroxyapatites - pharmacology Organic Chemicals - pharmacokinetics Organic Chemicals - pharmacology Surgery Swine Swine, Miniature |
| title | Histologic study of incorporation and resorption of a bone cement–collagen composite: an in vivo study in the minipig |
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