Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation

The products of the TSC1 (hamartin) and TCS2 (tuberin) tumor suppressor genes negatively regulate cell growth by inhibiting mTOR signaling. Recent research has led to the postulation that tuberin and/or hamartin are involved in tumor migration, presumably through Rho activation. Here we show that LE...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-03, Vol.368 (1), p.132-137
Hauptverfasser:	Suzuki, Tsukasa, Das, Swadesh K., Inoue, Hirohumi, Kazami, Machiko, Hino, Okio, Kobayashi, Toshiyuki, Yeung, Raymond S., Kobayashi, Ken-Ichi, Tadokoro, Tadahiro, Yamamoto, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Movement Cercopithecus aethiops Enzyme Activation Hamartin Mice Migration Mutation - genetics Protein Binding Rac1 rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rats Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Tuberin Tuberous sclerosis complex (TSC) Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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