Structural Heterogeneity of Type I Collagen Triple Helix and Its Role in Osteogenesis Imperfecta

We investigated regions of different helical stability within human type I collagen and discussed their role in intermolecular interactions and osteogenesis imperfecta (OI). By differential scanning calorimetry and circular dichroism, we measured and mapped changes in the collagen melting temperatur...

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Veröffentlicht in:	The Journal of biological chemistry 2008-02, Vol.283 (8), p.4787-4798
Hauptverfasser:	Makareeva, Elena, Mertz, Edward L., Kuznetsova, Natalia V., Sutter, Mary B., DeRidder, Angela M., Cabral, Wayne A., Barnes, Aileen M., McBride, Daniel J., Marini, Joan C., Leikin, Sergey
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular Dichroism Collagen Type I - chemistry Humans Osteogenesis Imperfecta Peptide Mapping Protein Folding Protein Structure, Quaternary Protein Structure, Secondary
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