Hypermagnesemia Predicts Mortality in Elderly with Congestive Heart Disease: Relationship with Laxative and Antacid Use

The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients ≥ 65 years old with a diagnosi...

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Veröffentlicht in:Rejuvenation research 2008-02, Vol.11 (1), p.129-138
Hauptverfasser: Corbi, Graziamaria, Acanfora, Domenico, Iannuzzi, Gian Luca, Longobardi, Giancarlo, Cacciatore, Francesco, Furgi, Giuseppe, Filippelli, Amelia, Rengo, Giuseppe, Leosco, Dario, Ferrara, Nicola
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container_issue 1
container_start_page 129
container_title Rejuvenation research
container_volume 11
creator Corbi, Graziamaria
Acanfora, Domenico
Iannuzzi, Gian Luca
Longobardi, Giancarlo
Cacciatore, Francesco
Furgi, Giuseppe
Filippelli, Amelia
Rengo, Giuseppe
Leosco, Dario
Ferrara, Nicola
description The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients ≥ 65 years old with a diagnosis of CHF underwent clinical and instrumental examination, and their demographics, co-morbidity, and in-hospital and 3-year mortality rates were recorded. Hypomagnesemia was found in 4.8%, normomagnesemia in 67.5%, and hypermagnesemia in 27.8% of subjects. The hypomagnesemic group was excluded for numerical exiguity; the analysis was performed on a total of 199 elderly patients. Hypermagnesemia was found in 29.1% and normomagnesemia in 70.9%. At the univariate analysis no differences were found in hypermagnesemia in respect to normomagnesemia group, except for slightly higher levels of creatininemia (1.35 ± 0.61 vs. 1.13 ± 0.55 mg/dL, respectively; p < 0.02), greater disability (lost ADL, 2.69 ± 1.57 vs. 2.15 ± 1.56, respectively; p < 0.05), more mortality for CHF (32.6 vs. 48.3%; p < 0.05), and higher antacid and laxative use (82.7 vs. 24.8%, respectively; p < 0.0001). Patients with higher magnesium showed less probability to survive at a 3-year follow-up than did patients with lower levels (17.32 ± 15.93 vs. 22.46 ± 16.16 months; p < 0.05), and this finding remained significant in the multivariate analysis after adjusting for some confounders. Finally hypermagnesemia should also be considered in the absence of pre-existing renal failure clinical evidence because of its negative prognostic value, especially in elderly patients with CHF. The shown relationship between hypermagnesemia and laxative/antacid use should induce physicians to pay more attention to abuse of these drugs.
doi_str_mv 10.1089/rej.2007.0583
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At the univariate analysis no differences were found in hypermagnesemia in respect to normomagnesemia group, except for slightly higher levels of creatininemia (1.35 ± 0.61 vs. 1.13 ± 0.55 mg/dL, respectively; p &lt; 0.02), greater disability (lost ADL, 2.69 ± 1.57 vs. 2.15 ± 1.56, respectively; p &lt; 0.05), more mortality for CHF (32.6 vs. 48.3%; p &lt; 0.05), and higher antacid and laxative use (82.7 vs. 24.8%, respectively; p &lt; 0.0001). Patients with higher magnesium showed less probability to survive at a 3-year follow-up than did patients with lower levels (17.32 ± 15.93 vs. 22.46 ± 16.16 months; p &lt; 0.05), and this finding remained significant in the multivariate analysis after adjusting for some confounders. Finally hypermagnesemia should also be considered in the absence of pre-existing renal failure clinical evidence because of its negative prognostic value, especially in elderly patients with CHF. 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At the univariate analysis no differences were found in hypermagnesemia in respect to normomagnesemia group, except for slightly higher levels of creatininemia (1.35 ± 0.61 vs. 1.13 ± 0.55 mg/dL, respectively; p &lt; 0.02), greater disability (lost ADL, 2.69 ± 1.57 vs. 2.15 ± 1.56, respectively; p &lt; 0.05), more mortality for CHF (32.6 vs. 48.3%; p &lt; 0.05), and higher antacid and laxative use (82.7 vs. 24.8%, respectively; p &lt; 0.0001). Patients with higher magnesium showed less probability to survive at a 3-year follow-up than did patients with lower levels (17.32 ± 15.93 vs. 22.46 ± 16.16 months; p &lt; 0.05), and this finding remained significant in the multivariate analysis after adjusting for some confounders. Finally hypermagnesemia should also be considered in the absence of pre-existing renal failure clinical evidence because of its negative prognostic value, especially in elderly patients with CHF. 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Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients ≥ 65 years old with a diagnosis of CHF underwent clinical and instrumental examination, and their demographics, co-morbidity, and in-hospital and 3-year mortality rates were recorded. Hypomagnesemia was found in 4.8%, normomagnesemia in 67.5%, and hypermagnesemia in 27.8% of subjects. The hypomagnesemic group was excluded for numerical exiguity; the analysis was performed on a total of 199 elderly patients. Hypermagnesemia was found in 29.1% and normomagnesemia in 70.9%. At the univariate analysis no differences were found in hypermagnesemia in respect to normomagnesemia group, except for slightly higher levels of creatininemia (1.35 ± 0.61 vs. 1.13 ± 0.55 mg/dL, respectively; p &lt; 0.02), greater disability (lost ADL, 2.69 ± 1.57 vs. 2.15 ± 1.56, respectively; p &lt; 0.05), more mortality for CHF (32.6 vs. 48.3%; p &lt; 0.05), and higher antacid and laxative use (82.7 vs. 24.8%, respectively; p &lt; 0.0001). Patients with higher magnesium showed less probability to survive at a 3-year follow-up than did patients with lower levels (17.32 ± 15.93 vs. 22.46 ± 16.16 months; p &lt; 0.05), and this finding remained significant in the multivariate analysis after adjusting for some confounders. Finally hypermagnesemia should also be considered in the absence of pre-existing renal failure clinical evidence because of its negative prognostic value, especially in elderly patients with CHF. The shown relationship between hypermagnesemia and laxative/antacid use should induce physicians to pay more attention to abuse of these drugs.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>18279030</pmid><doi>10.1089/rej.2007.0583</doi><tpages>10</tpages></addata></record>
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subjects Aged
Aged, 80 and over
Antacids
Antacids - adverse effects
Chemical properties
Complications and side effects
Congestive heart failure
Drug use
Female
Follow-Up Studies
Health aspects
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - etiology
Heart Failure - mortality
Humans
Laxatives
Laxatives - adverse effects
Magnesium - blood
Magnesium imbalance
Male
Morbidity
ORIGINAL PAPERS
Patient outcomes
Physiological aspects
Prognosis
Prospective Studies
Risk factors
Survival Analysis
title Hypermagnesemia Predicts Mortality in Elderly with Congestive Heart Disease: Relationship with Laxative and Antacid Use
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