Gold nanoparticle-based tool to study protein conformational variants: implications in hemoglobinopathy

Abstract The size of gold nanoparticles is shown here to gradually decrease if it is allowed to grow on a protein template, and the protein is subjected to unfolding by a nonionic denaturant. The correlation between size of the gold nanoparticle formed and the plasmon frequency observed remains line...

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Veröffentlicht in:	Nanomedicine 2007-03, Vol.3 (1), p.14-19
Hauptverfasser:	Bhattacharya, Jaydeep, MTech, Jasrapuria, Sinu, MSc, Sarkar, Tapan, MSc, GhoshMoulick, Ranjita, MSc, Dasgupta, Anjan Kr., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Fluorescence Folding Gold Gold nanoparticle Hemoglobin Hemoglobinopathies - pathology Hemoglobinopathy Hemoglobins - chemistry Hemoglobins - metabolism Humans Internal Medicine Nanoparticles Particle Size Plasmon resonance Protein Conformation Protein Folding Serum albumin Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - metabolism Surface Plasmon Resonance Tryptophan Tyrosine Urea
Online-Zugang:	Volltext
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