Pathogenesis of calciphylaxis: Hans Selye to nuclear factor κ-B

Pathogenesis of calciphylaxis: Hans Selye to nuclear factor κ-B

The clinical syndrome of calciphylaxis is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, necrotic skin ulceration, and a high mortality rate. This review integrates calciphylaxis risk factors with the molecular processes governing osseous and extraosseous mineraliza...

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Veröffentlicht in:Journal of the American Academy of Dermatology 2008-03, Vol.58 (3), p.458-471
1. Verfasser: Weenig, Roger H., MD, MPH
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Bone Resorption - metabolism
Calcification, Physiologic
Calciphylaxis - etiology
Calciphylaxis - history
Calciphylaxis - metabolism
Calciphylaxis - therapy
Calcium - metabolism
Dermatology
History, 20th Century
Humans
Ligands
Medical sciences
NF-kappa B - metabolism
Parathyroid Hormone - metabolism
Phosphates - metabolism
Receptors, Cell Surface - metabolism
SElye
United States
Vascular Diseases - etiology
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Zusammenfassung:The clinical syndrome of calciphylaxis is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, necrotic skin ulceration, and a high mortality rate. This review integrates calciphylaxis risk factors with the molecular processes governing osseous and extraosseous mineralization. As the pathogenesis of calciphylaxis is better understood, targeted therapies aimed at disease prevention and reversal will follow.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2007.12.006