Cellular prion protein co-localizes with nAChR beta4 subunit in brain and gastrointestinal tract

PrP(C), the cellular isoform of prion protein, is widely expressed in most tissues, including brain, muscle and gastrointestinal tract. Despite its involvement in several bioprocesses, PrP has still no apparent physiological role. During propagation of transmissible spongiform encephalopathies (TSE)...

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Veröffentlicht in:	The European journal of neuroscience 2008-02, Vol.27 (3), p.612-620
Hauptverfasser:	Petrakis, S, Irinopoulou, T, Panagiotidis, C H, Engelstein, R, Lindstrom, J, Orr-Urtreger, A, Gabizon, R, Grigoriadis, N, Sklaviadis, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain - ultrastructure Female Fluorescent Antibody Technique Gastrointestinal Tract - metabolism Gastrointestinal Tract - ultrastructure Humans Immunity, Innate - genetics Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Prion Diseases - genetics Prion Diseases - metabolism Prion Diseases - physiopathology Protein Subunits - genetics Protein Subunits - metabolism PrPC Proteins - metabolism PrPSc Proteins - pathogenicity Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism Sheep Subcellular Fractions
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