Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer
Background The immediate early response gene X-1 (IEX-1) is a stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis. The aim of this study was to evaluate the prognostic significance of IEX-1 expression in pancreatic cancer. Methods IEX-1 protein expression...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology 2008-02, Vol.15 (2), p.609-617 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 617 |
|---|---|
| container_issue | 2 |
| container_start_page | 609 |
| container_title | Annals of surgical oncology |
| container_volume | 15 |
| creator | Sasada, Tetsuro Azuma, Koichi Hirai, Tatsuya Hashida, Hiroki Kanai, Michiyuki Yanagawa, Takashi Takabayashi, Arimichi |
| description | Background
The immediate early response gene X-1 (IEX-1) is a stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis. The aim of this study was to evaluate the prognostic significance of IEX-1 expression in pancreatic cancer.
Methods
IEX-1 protein expression was examined on paraffin-embedded specimens from 78 patients with pancreatic ductal adenocarcinoma using immunohistochemistry. The relationships between the IEX-1 expression and other clinicopathological parameters and patient survival were evaluated. A similar analysis was conducted in a subgroup of 48 patients, who underwent a macroscopically curative resection with detailed information on the pathological findings.
Results
Among 78 pancreatic cancer patients, 41 patients (53%) were positive for IEX-1 staining. In a multivariate analysis, curative operation (
P
|
| doi_str_mv | 10.1245/s10434-007-9669-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70297924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1440058591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-25b741081157b243db277cd3b54b4d02f223c08dc0e4de8fc2cf7e851334aec3</originalsourceid><addsrcrecordid>eNp1kU1rGzEQhkVpqBO3PyCXIHoI6WHb0ddq9xiM6xoMNa0PvYld7aytYEuOtIb431fGhkAgpxHSM8-IeQm5ZfCdcal-JAZSyAJAF3VZ1gV8INdM5RtZVuxjPkNZFTUv1YjcpPQEwLQA9YmMWAW81HV9TTbLGNY-pMFZ-tetveudbbxFGno6bJDOdzvsXDMgnTZxe6R_MO2DT0hn6JH-Kxh9mE9z-UanL_uIKbngqfN0mSURm5N2cvLFz-Sqb7YJv1zqmKx-TleTX8Xi92w-eVwUVgo1FFy1WjKoGFO65VJ0LdfadqJVspUd8J5zYaHqLKDssOott73GSjEhZINWjMn9WbuP4fmAaTA7lyxut43HcEhGA691ncVj8vUN-BQO0eevGc61UExyliF2hmwMKUXszT66XROPhoE5RWDOEZgcgTlFYCD33F3Ehzbv7rXjsvMM8DOQ8pNfY3yd_L71PzkMj38</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>227351421</pqid></control><display><type>article</type><title>Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Sasada, Tetsuro ; Azuma, Koichi ; Hirai, Tatsuya ; Hashida, Hiroki ; Kanai, Michiyuki ; Yanagawa, Takashi ; Takabayashi, Arimichi</creator><creatorcontrib>Sasada, Tetsuro ; Azuma, Koichi ; Hirai, Tatsuya ; Hashida, Hiroki ; Kanai, Michiyuki ; Yanagawa, Takashi ; Takabayashi, Arimichi</creatorcontrib><description>Background
The immediate early response gene X-1 (IEX-1) is a stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis. The aim of this study was to evaluate the prognostic significance of IEX-1 expression in pancreatic cancer.
Methods
IEX-1 protein expression was examined on paraffin-embedded specimens from 78 patients with pancreatic ductal adenocarcinoma using immunohistochemistry. The relationships between the IEX-1 expression and other clinicopathological parameters and patient survival were evaluated. A similar analysis was conducted in a subgroup of 48 patients, who underwent a macroscopically curative resection with detailed information on the pathological findings.
Results
Among 78 pancreatic cancer patients, 41 patients (53%) were positive for IEX-1 staining. In a multivariate analysis, curative operation (
P
< .001), pathological stage I–III (
P
= .001), and positive IEX-1 expression (
P
= .002) were significantly favorable factors for survival. In a subgroup of 48 patients undergoing a macroscopically curative surgery, IEX-1 expression was positive in 28 patients (58%). A significant negative correlation was observed between the IEX-1 expression and serosal (
P
= .032) or arterial (
P
= .040) invasion of tumors. A multivariate analysis demonstrated limited local invasion (pT1-3,
P
= .021), negative lymph node involvement (pN0,
P
< .001), and positive IEX-1 expression (
P
= .004) to be significantly favorable factors for survival.
Conclusions
The positive IEX-1 expression in tumor tissues may be associated with a better prognosis in pancreatic cancer. An immunohistochemical assessment of IEX-1 expression may therefore be helpful for predicting patient prognosis in this disease.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-007-9669-0</identifier><identifier>PMID: 18026799</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Apoptosis - physiology ; Apoptosis Regulatory Proteins - metabolism ; Female ; Hepatic and Pancreatic Tumors ; Humans ; Immunohistochemistry ; Male ; Medicine ; Medicine & Public Health ; Membrane Proteins - metabolism ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Oncology ; Pancreatic cancer ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Paraffin Embedding ; Prognosis ; Surgery ; Surgical Oncology</subject><ispartof>Annals of surgical oncology, 2008-02, Vol.15 (2), p.609-617</ispartof><rights>Society of Surgical Oncology 2007</rights><rights>Society of Surgical Oncology 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-25b741081157b243db277cd3b54b4d02f223c08dc0e4de8fc2cf7e851334aec3</citedby><cites>FETCH-LOGICAL-c435t-25b741081157b243db277cd3b54b4d02f223c08dc0e4de8fc2cf7e851334aec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-007-9669-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-007-9669-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18026799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasada, Tetsuro</creatorcontrib><creatorcontrib>Azuma, Koichi</creatorcontrib><creatorcontrib>Hirai, Tatsuya</creatorcontrib><creatorcontrib>Hashida, Hiroki</creatorcontrib><creatorcontrib>Kanai, Michiyuki</creatorcontrib><creatorcontrib>Yanagawa, Takashi</creatorcontrib><creatorcontrib>Takabayashi, Arimichi</creatorcontrib><title>Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
The immediate early response gene X-1 (IEX-1) is a stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis. The aim of this study was to evaluate the prognostic significance of IEX-1 expression in pancreatic cancer.
Methods
IEX-1 protein expression was examined on paraffin-embedded specimens from 78 patients with pancreatic ductal adenocarcinoma using immunohistochemistry. The relationships between the IEX-1 expression and other clinicopathological parameters and patient survival were evaluated. A similar analysis was conducted in a subgroup of 48 patients, who underwent a macroscopically curative resection with detailed information on the pathological findings.
Results
Among 78 pancreatic cancer patients, 41 patients (53%) were positive for IEX-1 staining. In a multivariate analysis, curative operation (
P
< .001), pathological stage I–III (
P
= .001), and positive IEX-1 expression (
P
= .002) were significantly favorable factors for survival. In a subgroup of 48 patients undergoing a macroscopically curative surgery, IEX-1 expression was positive in 28 patients (58%). A significant negative correlation was observed between the IEX-1 expression and serosal (
P
= .032) or arterial (
P
= .040) invasion of tumors. A multivariate analysis demonstrated limited local invasion (pT1-3,
P
= .021), negative lymph node involvement (pN0,
P
< .001), and positive IEX-1 expression (
P
= .004) to be significantly favorable factors for survival.
Conclusions
The positive IEX-1 expression in tumor tissues may be associated with a better prognosis in pancreatic cancer. An immunohistochemical assessment of IEX-1 expression may therefore be helpful for predicting patient prognosis in this disease.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis - physiology</subject><subject>Apoptosis Regulatory Proteins - metabolism</subject><subject>Female</subject><subject>Hepatic and Pancreatic Tumors</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membrane Proteins - metabolism</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Paraffin Embedding</subject><subject>Prognosis</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1rGzEQhkVpqBO3PyCXIHoI6WHb0ddq9xiM6xoMNa0PvYld7aytYEuOtIb431fGhkAgpxHSM8-IeQm5ZfCdcal-JAZSyAJAF3VZ1gV8INdM5RtZVuxjPkNZFTUv1YjcpPQEwLQA9YmMWAW81HV9TTbLGNY-pMFZ-tetveudbbxFGno6bJDOdzvsXDMgnTZxe6R_MO2DT0hn6JH-Kxh9mE9z-UanL_uIKbngqfN0mSURm5N2cvLFz-Sqb7YJv1zqmKx-TleTX8Xi92w-eVwUVgo1FFy1WjKoGFO65VJ0LdfadqJVspUd8J5zYaHqLKDssOott73GSjEhZINWjMn9WbuP4fmAaTA7lyxut43HcEhGA691ncVj8vUN-BQO0eevGc61UExyliF2hmwMKUXszT66XROPhoE5RWDOEZgcgTlFYCD33F3Ehzbv7rXjsvMM8DOQ8pNfY3yd_L71PzkMj38</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Sasada, Tetsuro</creator><creator>Azuma, Koichi</creator><creator>Hirai, Tatsuya</creator><creator>Hashida, Hiroki</creator><creator>Kanai, Michiyuki</creator><creator>Yanagawa, Takashi</creator><creator>Takabayashi, Arimichi</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer</title><author>Sasada, Tetsuro ; Azuma, Koichi ; Hirai, Tatsuya ; Hashida, Hiroki ; Kanai, Michiyuki ; Yanagawa, Takashi ; Takabayashi, Arimichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-25b741081157b243db277cd3b54b4d02f223c08dc0e4de8fc2cf7e851334aec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis - physiology</topic><topic>Apoptosis Regulatory Proteins - metabolism</topic><topic>Female</topic><topic>Hepatic and Pancreatic Tumors</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Membrane Proteins - metabolism</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Oncology</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Paraffin Embedding</topic><topic>Prognosis</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasada, Tetsuro</creatorcontrib><creatorcontrib>Azuma, Koichi</creatorcontrib><creatorcontrib>Hirai, Tatsuya</creatorcontrib><creatorcontrib>Hashida, Hiroki</creatorcontrib><creatorcontrib>Kanai, Michiyuki</creatorcontrib><creatorcontrib>Yanagawa, Takashi</creatorcontrib><creatorcontrib>Takabayashi, Arimichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasada, Tetsuro</au><au>Azuma, Koichi</au><au>Hirai, Tatsuya</au><au>Hashida, Hiroki</au><au>Kanai, Michiyuki</au><au>Yanagawa, Takashi</au><au>Takabayashi, Arimichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>15</volume><issue>2</issue><spage>609</spage><epage>617</epage><pages>609-617</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
The immediate early response gene X-1 (IEX-1) is a stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis. The aim of this study was to evaluate the prognostic significance of IEX-1 expression in pancreatic cancer.
Methods
IEX-1 protein expression was examined on paraffin-embedded specimens from 78 patients with pancreatic ductal adenocarcinoma using immunohistochemistry. The relationships between the IEX-1 expression and other clinicopathological parameters and patient survival were evaluated. A similar analysis was conducted in a subgroup of 48 patients, who underwent a macroscopically curative resection with detailed information on the pathological findings.
Results
Among 78 pancreatic cancer patients, 41 patients (53%) were positive for IEX-1 staining. In a multivariate analysis, curative operation (
P
< .001), pathological stage I–III (
P
= .001), and positive IEX-1 expression (
P
= .002) were significantly favorable factors for survival. In a subgroup of 48 patients undergoing a macroscopically curative surgery, IEX-1 expression was positive in 28 patients (58%). A significant negative correlation was observed between the IEX-1 expression and serosal (
P
= .032) or arterial (
P
= .040) invasion of tumors. A multivariate analysis demonstrated limited local invasion (pT1-3,
P
= .021), negative lymph node involvement (pN0,
P
< .001), and positive IEX-1 expression (
P
= .004) to be significantly favorable factors for survival.
Conclusions
The positive IEX-1 expression in tumor tissues may be associated with a better prognosis in pancreatic cancer. An immunohistochemical assessment of IEX-1 expression may therefore be helpful for predicting patient prognosis in this disease.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>18026799</pmid><doi>10.1245/s10434-007-9669-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2008-02, Vol.15 (2), p.609-617 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70297924 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Aged, 80 and over Apoptosis - physiology Apoptosis Regulatory Proteins - metabolism Female Hepatic and Pancreatic Tumors Humans Immunohistochemistry Male Medicine Medicine & Public Health Membrane Proteins - metabolism Middle Aged Multivariate Analysis Neoplasm Invasiveness Oncology Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Paraffin Embedding Prognosis Surgery Surgical Oncology |
| title | Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T20%3A04%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20Significance%20of%20the%20Immediate%20Early%20Response%20Gene%20X-1%20(IEX-1)%20Expression%20in%20Pancreatic%20Cancer&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Sasada,%20Tetsuro&rft.date=2008-02-01&rft.volume=15&rft.issue=2&rft.spage=609&rft.epage=617&rft.pages=609-617&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-007-9669-0&rft_dat=%3Cproquest_cross%3E1440058591%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=227351421&rft_id=info:pmid/18026799&rfr_iscdi=true |