Adapting Proteostasis for Disease Intervention
The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting a...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2008-02, Vol.319 (5865), p.916-919 |
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| container_issue | 5865 |
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| creator | Balch, William E Morimoto, Richard I Dillin, Andrew Kelly, Jeffery W |
| description | The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era. |
| doi_str_mv | 10.1126/science.1141448 |
| format | Article |
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Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1141448</identifier><identifier>PMID: 18276881</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Aggregation ; Aging ; Alzheimers disease ; Animals ; Biological and medical sciences ; Biomedical research ; Cell Line ; Cell Physiological Phenomena ; Cellular biology ; Drug Therapy ; Fundamental and applied biological sciences. 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Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era.</description><subject>Aggregation</subject><subject>Aging</subject><subject>Alzheimers disease</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical research</subject><subject>Cell Line</subject><subject>Cell Physiological Phenomena</subject><subject>Cellular biology</subject><subject>Drug Therapy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gaucher disease</subject><subject>General aspects</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Huntington disease</subject><subject>Infection - drug therapy</subject><subject>Infection - metabolism</subject><subject>Metabolic diseases</subject><subject>Metabolic Diseases - drug therapy</subject><subject>Metabolic Diseases - metabolism</subject><subject>Metabolic Networks and Pathways</subject><subject>Molecular and cellular biology</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Nervous system diseases</subject><subject>Neurodegenerative diseases</subject><subject>Physiological regulation</subject><subject>Protein Conformation</subject><subject>Protein Folding</subject><subject>Protein Transport</subject><subject>Proteins</subject><subject>Proteins - chemistry</subject><subject>Proteins - metabolism</subject><subject>Proteins - therapeutic use</subject><subject>Proteomes</subject><subject>Proteomics</subject><subject>Regulator genes</subject><subject>Review</subject><subject>Signal Transduction</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9rFDEUx4Modls9e1KXgt6mfUkmmZdjqb8KBQXtOWSSN2WW3cmaN1vwvzeyg4oXTyF8Pu9L3jdCvJBwIaWylxxHmiLVSyvbFh-JlQRnGqdAPxYrAG0bhM6ciFPmDUBlTj8VJxJVZxHlSlxcpbCfx-l-_aXkmTLPgUdeD7ms341MgWl9M81UHmiaxzw9E0-GsGV6vpxn4u7D-2_Xn5rbzx9vrq9um2g6OTeuMzai60PfU0pa9oRgo9JJSSWxxS7GVsY0tBgwmaB7IrQpGhx0m2KdOBNvj7n7kr8fiGe_GznSdhsmygf2HSjXqQ7_K0rXWosWqnj-j7jJhzLVJbyS2jgLUlfp8ijFkpkLDX5fxl0oP7wE_6twvxTul8LrxKsl9tDvKP3xl4ar8GYRAsewHUqY4si_PQWq_hiY6r08ehuec_mLV6atq_z1kQ8h-3BfasbdV1UfDYDGOYP6J5UBnAs</recordid><startdate>20080215</startdate><enddate>20080215</enddate><creator>Balch, William E</creator><creator>Morimoto, Richard I</creator><creator>Dillin, Andrew</creator><creator>Kelly, Jeffery W</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080215</creationdate><title>Adapting Proteostasis for Disease Intervention</title><author>Balch, William E ; Morimoto, Richard I ; Dillin, Andrew ; Kelly, Jeffery W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-9756c89babbedd31be806c23d21218487cc41cdf48a8d5a3bee86dc58f34dcdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aggregation</topic><topic>Aging</topic><topic>Alzheimers disease</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical research</topic><topic>Cell Line</topic><topic>Cell Physiological Phenomena</topic><topic>Cellular biology</topic><topic>Drug Therapy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gaucher disease</topic><topic>General aspects</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Huntington disease</topic><topic>Infection - drug therapy</topic><topic>Infection - metabolism</topic><topic>Metabolic diseases</topic><topic>Metabolic Diseases - drug therapy</topic><topic>Metabolic Diseases - metabolism</topic><topic>Metabolic Networks and Pathways</topic><topic>Molecular and cellular biology</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Nervous system diseases</topic><topic>Neurodegenerative diseases</topic><topic>Physiological regulation</topic><topic>Protein Conformation</topic><topic>Protein Folding</topic><topic>Protein Transport</topic><topic>Proteins</topic><topic>Proteins - chemistry</topic><topic>Proteins - metabolism</topic><topic>Proteins - therapeutic use</topic><topic>Proteomes</topic><topic>Proteomics</topic><topic>Regulator genes</topic><topic>Review</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balch, William E</creatorcontrib><creatorcontrib>Morimoto, Richard I</creatorcontrib><creatorcontrib>Dillin, Andrew</creatorcontrib><creatorcontrib>Kelly, Jeffery W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balch, William E</au><au>Morimoto, Richard I</au><au>Dillin, Andrew</au><au>Kelly, Jeffery W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adapting Proteostasis for Disease Intervention</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2008-02-15</date><risdate>2008</risdate><volume>319</volume><issue>5865</issue><spage>916</spage><epage>919</epage><pages>916-919</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The protein components of eukaryotic cells face acute and chronic challenges to their integrity. 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| ispartof | Science (American Association for the Advancement of Science), 2008-02, Vol.319 (5865), p.916-919 |
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| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Aggregation Aging Alzheimers disease Animals Biological and medical sciences Biomedical research Cell Line Cell Physiological Phenomena Cellular biology Drug Therapy Fundamental and applied biological sciences. Psychology Gaucher disease General aspects Homeostasis Humans Huntington disease Infection - drug therapy Infection - metabolism Metabolic diseases Metabolic Diseases - drug therapy Metabolic Diseases - metabolism Metabolic Networks and Pathways Molecular and cellular biology Neoplasms - drug therapy Neoplasms - metabolism Nervous system diseases Neurodegenerative diseases Physiological regulation Protein Conformation Protein Folding Protein Transport Proteins Proteins - chemistry Proteins - metabolism Proteins - therapeutic use Proteomes Proteomics Regulator genes Review Signal Transduction |
| title | Adapting Proteostasis for Disease Intervention |
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